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Quantitative model for genome-wide cyclic AMP receptor protein binding site identification and characteristic analysis
Brief Bioinform. 2023 Apr 27:bbad138. doi: 10.1093/bib/bbad138. Online ahead of print.ABSTRACTCyclic AMP receptor proteins (CRPs) are important transcription regulators in many species. The prediction of CRP-binding sites was mainly based on position-weighted matrixes (PWMs). Traditional prediction methods only considered known binding motifs, and their ability to discover inflexible binding patterns was limited. Thus, a novel CRP-binding site prediction model called CRPBSFinder was developed in this research, which combined the hidden Markov model, knowledge-based PWMs and structure-based binding affinity matrixes. We tra...
Source: Briefings in Bioinformatics - April 28, 2023 Category: Bioinformatics Authors: Yigang Chen Yang-Chi-Dung Lin Yijun Luo Xiaoxuan Cai Peng Qiu Shidong Cui Zhe Wang Hsi-Yuan Huang Hsien-Da Huang Source Type: research

Diagnosing complex regional pain syndrome using an electronic nose, a pilot study
This study was a feasibility study in which we investigated whether th...
Source: Journal of Breath Research - April 14, 2019 Category: Respiratory Medicine Authors: E J Bijl, J G Groeneweg, D W Wesselius, D L Stronks and F J P M Huygen Source Type: research

Preparation of Controlled-Release Particles Based on Spherical Porous Silica Used as the Drug Carrier by the Dry Coating Method.
Abstract A controlled-release formulation is a dosage form that could improve a patient's quality of life by reducing the frequency of administration, while ensuring the continued effect of the medicine and reducing the side effects. To prepare these controlled-release particles, a wet coating method in which a drug is coated with a controlled-release material using water or an organic solvent is used, but with this method, the coating process is very time-consuming and requires large amounts of energy for the drying phase. In addition, contact with water or an organic solvent may cause problems such as alteration...
Source: AAPS PharmSciTech - February 12, 2018 Category: Drugs & Pharmacology Authors: Nakamura S, Kondo S, Mohri A, Sakamoto T, Yuasa H Tags: AAPS PharmSciTech Source Type: research