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Intravenous treatment with biphosphates in Complex Regional Pain Syndrome
Conclusion: Our study showed that the CRPS affects a population between 42 and 78 years, especially women. Treatment with intravenous bisphosphonates seems to lead to an improvement in CRPS symptoms, in particular administration between 3 and 6 months after the onset of the disease. In particular, women over 61 years of age seem to have a lower improvement in symptomatology after treatment. 52% of cases report that they still have joint stiffness.PMID:34487084 | DOI:10.23750/abm.v92i4.11194
Source: Acta Bio-Medica : Atenei Parmensis - September 6, 2021 Category: General Medicine Authors: Marianna Faggiani Alice Piccato Chiara Baroni Salvatore Risitano Luigi Giulio Conforti Source Type: research

Cysteine-rich peptides: hyperstable scaffolds for protein engineering.
Abstract Cysteine-rich peptides (CRPs) are small proteins of less than 100 amino acids in length characterized by the presence of disulfide bridges and common end-to-end macrocyclization. These properties confer hyperstability against high temperatures, salt concentration, serum presence, and protease degradation to CRPs. Besides, their inter-cysteine domains (loops) are susceptible to residue hypervariability. CRPs have been successfully applied as stable scaffolds for molecular grafting, a protein engineering process where cysteine-rich structures provide higher thermodynamic and metabolic stability to an epitop...
Source: Chembiochem - October 23, 2020 Category: Biochemistry Authors: Gonzalez-Castro R, Gomez-Lim MA, Plisson F Tags: Chembiochem Source Type: research