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Complex regional pain syndrome as a paraneoplastic disorder associated with metatypical basal cell carcinoma.
Authors: Gofiţă CE, Ciurea ME, Dinescu ŞC, Vreju AF, Stoica LE, Ciurea RN, Boldeanu MV, Rogoveanu OC, Trăistaru MR, Bumbea AM, Ciurea PL, Muşetescu AE Abstract Metatypical basal cell carcinoma (MTBCC) is a rare form of tumor, which associates the clinical and histopathological (HP) characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), with a 5% chance for the development of metastases. The reference diagnosis remains the HP confirmation from the lesional tissue. The current report illustrates the case of a 74-year-old patient, diagnosed with MTBCC consequently to the biopsy from...
Source: Romanian Journal of Morphology and Embryology - October 29, 2019 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Dermal nerve fibre and mast cell density, and proximity of mast cells to nerve fibres in the skin of patients with complex regional pain syndrome
An interaction between cutaneous nerves and mast cells may contribute to pain in complex regional pain syndrome (CRPS). To explore this, we investigated the density of dermal nerve fibres, and the density and proximity of mast cells to nerve fibres, in skin biopsies obtained from the affected and unaffected limbs of 57 patients with CRPS and 28 site-matched healthy controls. The percentage of the dermis stained by the pan-neuronal marker protein gene-product 9.5 was lower in the affected limb of patients than in controls (0.12 ± 0.01% vs 0.22 ± 0.04%, P
Source: Pain - October 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

0P24. T cells and anti-inflammatory interleukins in skin biopsies of Complex Regional Pain Syndrome (CRPS)
CRPS (Complex regional Pain Syndrome) is a neuropathic pain syndrome occurring after trauma. It is associated with increased posttraumatic inflammation. Patients show inflammatory signs like increased skin temperature, edema, hyperhidrosis, and hypertrichosis. In CRPS blood samples pro-inflammatory cytokines were increased and anti-inflammatory cytokines reduced. We found in skin biopsies an increase of pro-inflammatory cytokines (TNF-α, Il-6) and mast cells. The aim of this study was the quantification of T cells and the immunohistochemical staining of anti-inflammatory interleukins and of Interferon-γ (IFN- in the skin of CRPS patients.
Source: Clinical Neurophysiology - July 5, 2015 Category: Neuroscience Authors: T. Schlereth, S. Bolz, N. Albrecht, F. Birklein Source Type: research

Chronic Regional Pain Syndrome: A Preliminary report on molecular mechanisms and structural correlates (S10.005)
CONCLUSIONS: We conclude that gene expression changes in peripheral nerve may contribute to pain perpetuation following nerve injury and further study is needed. Study supported by: Clinical Research Institute at Rambam.Disclosure: Dr. Murinson has nothing to disclose. Dr. Ghersin has nothing to disclose. Dr. Peled has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Murinson, B., Ghersin, Z., Peled, E. Tags: Pain and Palliative Care Source Type: research

Cutaneous immunopathology of long‐standing complex regional pain syndrome
ConclusionsImmune cell abnormalities are maintained in late‐stage CRPS disease as manifest by changes in epidermal LC density and tissue resident T‐cell phenotype.
Source: European Journal of Pain - February 1, 2015 Category: Anesthesiology Authors: S. Osborne, J. Farrell, R.J. Dearman, K. MacIver, D.J. Naisbitt, R.J. Moots, S.W. Edwards, A. Goebel Tags: Original Article Source Type: research

Up‐Regulation of Cutaneous α1‐Adrenoceptors in Complex Regional Pain Syndrome Type I
DiscussionEpidermal cells influence nociception by releasing ligands that act on sensory nerve fibers. Moreover, an increased expression of α1‐adrenoceptors on nociceptive afferents has been shown to aggravate neuropathic pain. Thus, the heightened expression of α1‐adrenoceptors in dermal nerves and epidermal cells might augment pain and neuroinflammatory disturbances after tissue injury in patients with CRPS type I.
Source: Pain Medicine - September 12, 2014 Category: Anesthesiology Authors: Philip M. Finch, Eleanor S. Drummond, Linda F. Dawson, Jacqueline K. Phillips, Peter D. Drummond Tags: Original Article Source Type: research

Activation of Cutaneous Immune Responses in Complex Regional Pain Syndrome
Abstract: The pathogenesis of complex regional pain syndrome (CRPS) is unresolved, but tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) are elevated in experimental skin blister fluid from CRPS-affected limbs, as is tryptase, a marker for mast cells. In the rat fracture model of CRPS, exaggerated sensory and sympathetic neural signaling stimulate keratinocyte and mast cell proliferation, causing the local production of high levels of inflammatory cytokines leading to pain behavior. The current investigation used CRPS patient skin biopsies to determine whether keratinocyte and mast cell proliferation occur in C...
Source: The Journal of Pain - January 24, 2014 Category: Materials Science Authors: Frank Birklein, Peter D. Drummond, Wenwu Li, Tanja Schlereth, Nahid Albrecht, Philip M. Finch, Linda F. Dawson, J. David Clark, Wade S. Kingery Tags: Original Reports Source Type: research

Changes Resembling Complex Regional Pain Syndrome Following Surgery and Immobilization
This study has identified CPRS-like features in the limbs of patients undergoing surgery followed by immobilization. Further studies using this population may be useful in refining our understanding of CRPS mechanisms and treatments for this condition.
Source: The Journal of Pain - March 4, 2013 Category: Materials Science Authors: Alison Pepper, Wenwu Li, Wade S. Kingery, Martin S. Angst, Catherine M. Curtin, J. David Clark Tags: Original Reports Source Type: research