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Undertreatment with Osimertinib in patient with multiple chemical sensitivity. A case report
We describe the case of a 74 year old woman with history of MCS and fibromyalgia in treatment with Osimertinib for EGFR-mutated NSCLC. Patient initially refused any form of active therapy for lung cancer, but thanks to teamwork and the important support of the psychologist, the patient decided to start treatment with Osimertinib at a reduced dose, not 80 mg but 40 mg. Subsequently, after few days , of his own free will and without informing the staff physicians, the patient changed the treatment schedule by taking one quarter of the dose of the medicine every other day, justifying this choice in therapeutic modification be...
Source: Clinical Lung Cancer - November 14, 2022 Category: Cancer & Oncology Authors: E Gozzi L Rossi S Taccogna F Angelini Source Type: research

Individual Factors Contributing to Nausea in First-Time Chemotherapy Patients: A Prospective Cohort Study
Conclusion: In this female cohort, younger patients with lower initial quality of life and a positive history of nausea were at higher risk to develop nausea after first time chemotherapy. These patients may benefit from psychological co-interventions that aim to enhance quality of life. Introduction Besides pain and constipation, nausea and vomiting are among the most disabling physical symptoms in patients receiving chemotherapy (Breen et al., 2009). In contrast to vomiting, the treatment of nausea remains challenging (Andrews and Sanger, 2014). Several risk factors have been described for the development of post...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Asbestos as a possible major cause of malignant lung tumors (including small cell carcinoma, adenocarcinoma & mesothelioma), brain tumors (i.e. astrocytoma & glioblastoma multiforme), many other malignant tumors, intractable pain including fibromyalgia, & some cardio-vascular pathology: Safe & effective methods of reducing asbestos from normal & pathological areas.
Asbestos as a possible major cause of malignant lung tumors (including small cell carcinoma, adenocarcinoma & mesothelioma), brain tumors (i.e. astrocytoma & glioblastoma multiforme), many other malignant tumors, intractable pain including fibromyalgia, & some cardio-vascular pathology: Safe & effective methods of reducing asbestos from normal & pathological areas. Acupunct Electrother Res. 2006;31(1-2):61-125 Authors: Omura Y Abstract High incidences of Small Cell Carcinoma & Adenocarcinoma of the lung, Astrocytoma & Glioblastoma Multiforme of the brain and Mesothelioma of ...
Source: Acupuncture and Electro-Therapeutics Research - November 30, 2015 Category: Complementary Medicine Tags: Acupunct Electrother Res Source Type: research

Macro‐creatine kinase: a neglected cause of elevated creatine kinase
Abstract Macro‐creatine kinase (macro‐CK) is a neglected cause of raised CK. Over a 10‐year period, we observed five cases. Three patients had macro‐CK type 1. One patient with fibromyalgia underwent several explorations to find a muscular pathology; another, who had elevated CK‐MB (muscle–brain fraction) activity, was referred to a cardiologist, and statin therapy was erroneously discontinued in two patients. Two patients had macro‐CK type 2: a man with a neuroendocrine carcinoma and a woman with rheumatoid arthritis. Diagnosis of type 1 obviates the need to carry out pointless and expensive investigations s...
Source: Internal Medicine Journal - April 1, 2015 Category: Internal Medicine Authors: F. Aljuani, A. Tournadre, S. Cecchetti, M. Soubrier, J. J. Dubost Tags: Brief Communication Source Type: research