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Acute Pain Management
This case-based session provided hospitalists with expert opinions and evidence-based approaches to navigate challenges when managing acute pain in the inpatient setting. Opioid prescription management can be especially problematic for hospitalists when caring for patients with chronic pain on long-term opiate therapy (LTOT) and those with opioid use disorder (OUD). Managing acute pain of the opiate-naïve patient in the inpatient setting There are multiple options in the hospitalist’s toolbox when managing acute pain in the inpatient setting. These include non-pharmacologic treatments and non-opioid and opioid pain medi...
Source: The Hospitalist - July 5, 2023 Category: Hospital Management Authors: Ronda Whitaker Tags: Clinical Guidelines Drug Therapy Opioid Resource Center Pain Source Type: research

Comorbidities (excluding lymphoma) in Sj ögren’s syndrome
AbstractThe information about comorbidities (excluding lymphoma) in primary Sj ögren’s syndrome (pSS) is relatively scarce. Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clin ical practice. On the other hand, the incidence of cardiovascular events and cancer in pSS is low, so information about them comes from large epidemiological studies or meta-analysis. For this reason, preclinical vascular disease is investigated by d...
Source: Rheumatology - May 13, 2021 Category: Rheumatology Source Type: research

Radicals, oxidative/nitrosative stress and preeclampsia.
Abstract Oxygen is used by eukaryotic cells for metabolic transformations and energy production in mitochondria. Under physiological conditions, there is a constant endogenous production of free radicals that interact as signaling molecules in physiological mechanisms. Free radicals are neutral molecules, which are produced by separation of ions and molecules. In regular conditions production and disposal of free radicals are at equilibrium. However this equilibrium may not always be experienced, where these species are not eliminated by antioxidants or are excessively produced. Unequalibrium of free radicals caus...
Source: Mini Reviews in Medicinal Chemistry - October 15, 2018 Category: Chemistry Authors: Taysi S, Tascan AS, Uuro MG, Demir M Tags: Mini Rev Med Chem Source Type: research

QTc in the elderly
A 76-year-old woman was referred to our hospital for the evaluation of significant mitral regurgitation. She had a history of mastectomy for breast cancer, paroxysmal atrial fibrillation, treated with amiodarone (200  mg once daily), and non-vitamin-K-oral anticoagulation; and fibromyalgia, necessitating the chronic intake of duloxetine (tricyclic antidepressant). Because of insufficient paint relief, her general practitioner had associated pregabilin (150 mg twice daily) a couple of days before admission. A lmost immediately after presentation, she collapsed because of a ventricular-fibrillation-arrest, prompting two ...
Source: European Heart Journal - January 30, 2018 Category: Cardiology Source Type: research

Physical activity and autoimmune diseases: Get moving and manage the disease
Publication date: Available online 3 November 2017 Source:Autoimmunity Reviews Author(s): Kassem Sharif, Abdulla Watad, Nicola Luigi Bragazzi, Micheal Lichtbroun, Howard Amital, Yehuda Shoenfeld Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous gr...
Source: Autoimmunity Reviews - November 4, 2017 Category: Allergy & Immunology Source Type: research

Trazodone for Insomnia: A Systematic Review
Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insomnia is an or...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research

Could the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients
Low level laser therapy (LLLT) was first introduced for potential clinical applications by Mester in the late 1960s. This form of laser treatment, currently referred to as photobiomodulation (PBM), limits radiation intensity by transferring low energy to tissues and thereby does not generate heat. Among the clinical indications for which LLLT has been reported to be efficacious are pain relief (back and neck, orthodontic, shoulder), wound healing, carpal tunnel syndrome, colorectal cancer, elbow disorders, fibromyalgia, lymphedema, musculoskeletal dysfunction, myofascial pain syndrome, neurological dysfunctions, patella-fe...
Source: Oral Oncology - February 3, 2016 Category: Cancer & Oncology Authors: Stephen T. Sonis, Sepehr Hashemi, Joel B. Epstein, Raj G. Nair, Judith E. Raber-Durlacher Tags: Review Source Type: research

Enquête auprès des médecins généralistes sur leur expérience et leur avis en matière de prescription d’activité physique
Publication date: Available online 31 January 2015 Source:Science & Sports Author(s): C. Gérin , P. Guillemot , M. Bayat , A.M. André , V. Daniel , P. Rochcongar Objectif Évaluer les connaissances des médecins généralistes d’Ille-et-Vilaine et des départements limitrophes en matière de recommandations d’activité physique régulière (APR), ainsi que leur avis et ressenti sur leur prescription écrite. Matériels et méthodes Une étude descriptive a été réalisée par envoi postal d’un questionnaire aux médecins généralistes. L’enquête s’est déroulée d’avril à juin 2010. Résultats...
Source: Science and Sports - February 1, 2015 Category: Sports Medicine Source Type: research

Diurnal and Twenty-Four-Hour Patterning of Human Diseases: Acute and Chronic Common and Uncommon Medical Conditions
The symptom intensity and mortality of human diseases, conditions, and syndromes exhibit diurnal or 24h patterning, e.g., skin: atopic dermatitis, urticaria, psoriasis, and palmar hyperhidrosis; gastrointestinal: esophageal reflux, peptic ulcer (including perforation and hemorrhage), cyclic vomiting syndrome, biliary colic, hepatic variceal hemorrhage, and proctalgia fugax; infection: susceptibility, fever, and mortality; neural: frontal, parietal, temporal, and occipital lobe seizures, Parkinson’s and Alzheimer’s disease, hereditary progressive dystonia, and pain (cancer, post-surgical, diabetic neuropathic and foot u...
Source: Sleep Medicine Reviews - July 18, 2014 Category: Sleep Medicine Authors: Michael H. Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C. Hermida, Ruana Tiseo, Linda L. Sackett-Lundeen, Erhard Haus Source Type: research

Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions
The symptom intensity and mortality of human diseases, conditions, and syndromes exhibit diurnal or 24 h patterning, e.g., skin: atopic dermatitis, urticaria, psoriasis, and palmar hyperhidrosis; gastrointestinal: esophageal reflux, peptic ulcer (including perforation and hemorrhage), cyclic vomiting syndrome, biliary colic, hepatic variceal hemorrhage, and proctalgia fugax; infection: susceptibility, fever, and mortality; neural: frontal, parietal, temporal, and occipital lobe seizures, Parkinson's and Alzheimer's disease, hereditary progressive dystonia, and pain (cancer, post-surgical, diabetic neuropathic and foot ulc...
Source: Sleep Medicine Reviews - July 18, 2014 Category: Sleep Medicine Authors: Michael H. Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C. Hermida, Ruana Tiseo, Linda L. Sackett-Lundeen, Erhard L. Haus Tags: Clinical review Source Type: research