Filtered By:
Cancer: Brain Cancers

This page shows you your search results in order of date.

Order by Relevance | Date

Total 22 results found since Jan 2013.

Microglia polarization in nociplastic pain: mechanisms and perspectives
AbstractNociplastic pain is the third classification of pain as described by the International Association for the Study of Pain (IASP), in addition to the neuropathic and nociceptive pain classes. The main pathophysiological mechanism for developing nociplastic pain is central sensitization (CS) in which pain amplification and hypersensitivity occur. Fibromyalgia is the prototypical nociplastic pain disorder, characterized by allodynia and hyperalgesia. Much scientific data suggest that classical activation of microglia in the spinal cord mediates neuroinflammation which plays an essential role in developing CS. In this r...
Source: Inflammopharmacology - April 17, 2023 Category: Drugs & Pharmacology Source Type: research

Cannabinoids as a Potential Alternative to Opioids in the Management of Various Pain Subtypes: Benefits, Limitations, and Risks
CONCLUSION: Cannabinoids may be effective in specific subtypes of pain, but current evidence and guidelines do not yet support its use as the first-line treatment for any type of acute or chronic pain. Rather, it may be considered a good adjunct or alternative for patients who have failed more typical or conservative measures. Additional studies are needed with standardized forms of cannabinoids, route of delivery, and dosing for greater-powered analysis. Providers must weigh the individualized patient risks, benefits, and concurrent medication list in order to determine whether cannabinoids are appropriate for a patient's...
Source: Cancer Control - January 13, 2023 Category: Cancer & Oncology Authors: Samuel P Ang Shawn Sidharthan Wilson Lai Nasir Hussain Kiran V Patel Amitabh Gulati Onyeaka Henry Alan D Kaye Vwaire Orhurhu Source Type: research

Potential role of blood biomarkers in patients with fibromyalgia: a systematic review with meta-analysis
Fibromyalgia (FM) is a complex chronic pain condition. Its symptoms are nonspecific, and to date, no objective test exists to confirm FM diagnosis. Potential objective measures include the circulating levels of blood biomarkers. This systematic review and meta-analysis aim to review studies assessing blood biomarkers' levels in patients with FM compared with healthy controls. We systematically searched the PubMed, MEDLINE, EMBASE, and PsycINFO databases. Fifty-four studies reporting the levels of biomarkers in blood in patients with FM were included. Data were extracted, and the methodological quality was assessed independ...
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Daphnetin, a natural coumarin averts reserpine-induced fibromyalgia in mice: modulation of MAO-A
Exp Brain Res. 2021 Mar 7. doi: 10.1007/s00221-021-06064-1. Online ahead of print.ABSTRACTFibromyalgia is a common, chronic, and generalized pain syndrome that is often associated with comorbid depression. The etiology of fibromyalgia is complex; most researchers have documented that the hallmark symptoms are due to the central nervous system's abnormal functioning. Neurotransmitters such as serotonin, norepinephrine, and glutamate, have been reported to be key regulators of fibromyalgia syndrome. Daphnetin is a 7, 8 dihydroxy coumarin widely distributed in Thymelaeaceae family plants, possessing various activities such as...
Source: Experimental Brain Research - March 7, 2021 Category: Neuroscience Authors: Lovedeep Singh Anudeep Kaur Amrit Pal Singh Rajbir Bhatti Source Type: research

Central Pain in Patient with Cancer (GP789)
Despite the current efforts to manage cancer pain with opioids, a significant number of cancer patients still experience pain. One reason may be that such patients have pain that comes from problems with the brain ’s processing of pain rather than nociception, neuropathy, or inflammation. Pain related to aberrant central nervous system processing is called “central pain.” Central pain is the key pathway in many chronic pain syndromes (e.g. fibromyalgia).
Source: Journal of Pain and Symptom Management - June 20, 2020 Category: Palliative Care Authors: Maria Silveira Source Type: research

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

The Cerebrospinal Fluid in Multiple Sclerosis
Conclusions OCB are important biomarkers that can support MRI diagnostics and help to avoid false-positive MS diagnoses. Therefore, the revised McDonalds criteria have increased the importance of the OCB. New biomarkers such as AQP4 have now established themselves in clinical practice, and others such as Anti-MOG and NfL are about to enter clinical routine. An important focus in the search for new biomarkers is the monitoring of therapy efficacy and the prediction of severe side effects. Many other CSF molecules such as CHI3L1, IL-6, or CXCL13 show potential as markers for clinical practice, but further research is nee...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Non electrical and non pharmacological ways of vagus nerve stimulation: Overview, pathways and clinical implications
Vagal nerve stimulation is gaining recognition as an important therapeutic approach especially for non-communicable diseases such as cardiovascular disease (CVD), Depression, Fibromyalgia, Arthritis, Type 2 Diabetes, Alzheimer, and certain types of cancer. In turn, decreased vagal tone its implicated in the prognosis of a wide range of diseases. Afferent vagal stimulation seems to have the key to reset certain pathophysiological states of the body leading to health improvement by reshaping neural networks.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: M. Tieck, I. Rojas, M. Jarczok Source Type: research

Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation
Publication date: Available online 20 June 2018Source: Brain, Behavior, and ImmunityAuthor(s): Xin Zhang, Jane E. Hartung, Andrey V. Bortsov, Seungtae Kim, Sandra C. O'Buckley, Julia Kozlowski, Andrea G. NackleyAbstractFunctional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Consistent with clinical syndromes, our lab has shown that sustained 14-day delivery of the COMT inhibitor OR486 in rodents results in pain at multiple body sites and pain-related...
Source: Brain, Behavior, and Immunity - July 10, 2018 Category: Neurology Source Type: research

Sustained Stimulation of β2- and β3-adrenergic Receptors Leads to Persistent Functional Pain and Neuroinflammation
Publication date: Available online 20 June 2018 Source:Brain, Behavior, and Immunity Author(s): Xin Zhang, Jane E. Hartung, Andrey V. Bortsov, Seungtae Kim, Sandra C. O'Buckley, Julia Kozlowski, Andrea G. Nackley Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Consistent with clinical syndromes, our lab has shown that sustained 14-day delivery of the COMT inhibitor OR486 in rodents results in pain at multiple body sites and pain-related voli...
Source: Brain, Behavior, and Immunity - June 21, 2018 Category: Neurology Source Type: research

Sustained Stimulation of β2- and β3-adrenergic Receptors Leads to Persistent Functional Pain and Neuroinflammation.
Abstract Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Consistent with clinical syndromes, our lab has shown that sustained 14-day delivery of the COMT inhibitor OR486 in rodents results in pain at multiple body sites and pain-related volitional behaviors. The onset of COMT-dependent functional pain is mediated by peripheral β2- and β3-adrenergic receptors (β2- and β3ARs) through the release of the pro-inflammatory cytokines tu...
Source: Brain, Behavior, and Immunity - June 20, 2018 Category: Neurology Authors: Zhang X, Hartung JE, Bortsov AV, Kim S, O'Buckley SC, Kozlowski J, Nackley AG Tags: Brain Behav Immun Source Type: research

Inflammatory biomarkers responses after acute whole body vibration in fibromyalgia.
In conclusion, a single acute session of mild and short WBV can improve the inflammatory status in patients with FM, reaching values close to those of matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced modulation towards greater adaptation to stress response in these patients. PMID: 29513791 [PubMed - in process]
Source: Brazilian Journal of Medical and Biological Research - March 9, 2018 Category: Research Tags: Braz J Med Biol Res Source Type: research