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Drug: Insulin
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Total 22 results found since Jan 2013.
Microglia polarization in nociplastic pain: mechanisms and perspectives
AbstractNociplastic pain is the third classification of pain as described by the International Association for the Study of Pain (IASP), in addition to the neuropathic and nociceptive pain classes. The main pathophysiological mechanism for developing nociplastic pain is central sensitization (CS) in which pain amplification and hypersensitivity occur. Fibromyalgia is the prototypical nociplastic pain disorder, characterized by allodynia and hyperalgesia. Much scientific data suggest that classical activation of microglia in the spinal cord mediates neuroinflammation which plays an essential role in developing CS. In this r...
Source: Inflammopharmacology - April 17, 2023 Category: Drugs & Pharmacology Source Type: research
Stress-associated weight gain, fibromyalgia symptoms, cardiometabolic markers, and human growth hormone suppression respond to an amino acid supplement blend: Results of a prospective, cohort study
DiscussionSustained augmentation of IGF-1 with the test supplement may represent a novel method of improving clinical symptoms, including stress-related weight gain, in individuals with fibromyalgia and stress-associated low-normal hGH.
Source: Frontiers in Endocrinology - March 14, 2023 Category: Endocrinology Source Type: research
Predictors of treatment response to serotonin and noradrenaline reuptake inhibitors in fibromyalgia
CONCLUSIONS: Significant differences in clinical, metabolic parameters and psychiatric comorbidities could explain the treatment response to SNRI in FM patients.PMID:36799096 | DOI:10.20452/pamw.16432
Source: Pain Physician - February 17, 2023 Category: Anesthesiology Authors: Anna J Krupa Mariusz Korkosz Aleksandra Gorostowicz Jaros ław Nowakowski Izabella Kierzkowska Dominika Dudek Marcin Siwek Source Type: research
IJERPH, Vol. 19, Pages 10362: Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways
In conclusion, lowered HR-Qol in Long COVID is largely predicted by the severity of neuro-immune and neuro-oxidative pathways during acute and Long COVID.
Source: International Journal of Environmental Research and Public Health - August 19, 2022 Category: Environmental Health Authors: Michael Maes Haneen Tahseen Al-Rubaye Abbas F. Almulla Dhurgham Shihab Al-Hadrawi Kristina Stoyanova Marta Kubera Hussein Kadhem Al-Hakeim Tags: Article Source Type: research
Metabolic effects of medical cannabis treatment
In this study, we prospectively evaluated patients recently starting medical cannabis treatment. All patients from the rheumatology clinic, who were just approved for medical cannabis treatment for resistant chronic pain, were recruited. After consent, demographic and clinical parameters were documented, including indication for medical cannabis treatment, way of consumption, type of cannabis and monthly dose of medical cannabis. Fasting morning blood glucose, hemoglobin A1c, insulin, lipid profile, cortisol and uric acid levels, in addition to body weight, were obtained just prior to and 3 months following cannabis consum...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Habib, G., Aamar, S. Tags: Brief report Source Type: research
Carotid Arterial Stiffness and Cardiometabolic Profiles in Women with Fibromyalgia
CONCLUSIONS: FM was associated with an increased risk of central obesity, high triglyceride levels, and IFG. Furthermore, advanced arterial stiffness of the carotid artery was observed in FM, which might be correlated with insulin resistance.PMID:34944602 | DOI:10.3390/biomedicines9121786
Source: Atherosclerosis - December 24, 2021 Category: Cardiology Authors: Yunkyung Kim Geun-Tae Kim Jihun Kang Source Type: research
Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model
CONCLUSION: PPAR-γ agonists show a promising role against FM-associated motor dysfunctions.PMID:34233552 | DOI:10.1080/07853890.2021.1916069
Source: Annals of Medicine - July 8, 2021 Category: Internal Medicine Authors: Fatma E Hassan Hader I Sakr Passant M Mohie Howayda Saeed Suliman Ayman Saber Mohamed Mohamed H Attia Dalia M Eid Source Type: research
Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia
CONCLUSION: The association demonstrated in this study warrant further investigation, including the pursuit of randomized, double-blind clinical trials to determine the effect of improving insulin sensitivity in FM related pain scores. Such studies could unveil a potential pathogenetic relationship between FM, central pain, and IR. Based on these initial findings, we present the hypothesis that IR may underlie pathological mechanisms leading to central pain. If confirmed, this may lead to a paradigm shift in the management of central pain.PMID:33740353
Source: Pain Physician - March 19, 2021 Category: Anesthesiology Authors: Miguel A Pappolla Laxmaiah Manchikanti Kenneth D Candido Nigel Grieg Michael Seffinger Fauwad Ahmed Xiang Fang Clark Andersen Andrea M Trescot Source Type: research
Metformin: A Prospective Alternative for the Treatment of Chronic Pain
Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug has been used for 60 years as a highly effective antihyperglycemic agent. The search for the mechanism of action of metformin has produced an enormous amount of research to explain its effects on gluconeogenesis, protein metabolism, fatty acid oxidation, oxidative stress, glucose uptake, autophagy and pain, among others. It was only up the end of the 1990s and beginning of this century that some of its mechanisms were revealed. Metformin induces its beneficial effects in diabetes through the activation of a master switch kinase name...
Source: Frontiers in Pharmacology - September 22, 2020 Category: Drugs & Pharmacology Source Type: research
Relationship of leptin, growth hormone, and insulin-like growth factor levels with body mass index and disease severity in patients with fibromyalgia syndrome
ConclusionWe found that leptin (high), GH (low), and IGF-1 (low) levels were statistically different, together with being independent of disease severity (FIQ, VAS), and correlated with BMI in the FMS group. These findings may be related with hypothalamo-pituitary axis dysfunction, BMI, and energy metabolism.
Source: Acta Neurologica Belgica - December 13, 2018 Category: Neurology Source Type: research
