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Drug: Melatonin

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Total 25 results found since Jan 2013.

Melatonin: Translation of Ongoing Studies Into Possible Therapeutic Applications Outside Sleep Disorders
Clin Ther. 2022 Apr 7:S0149-2918(22)00113-8. doi: 10.1016/j.clinthera.2022.03.008. Online ahead of print.ABSTRACTPURPOSE: Melatonin, a natural hormone mainly synthesized by the pineal gland, is regulated by circadian rhythm. Synthetic melatonin is not approved by the US Food and Drug Administration for any indication. However, melatonin receptor agonists such as ramelteon and tasimelteon are US Food and Drug Administration approved and are considered by the American Academy of Family Physicians for the treatment of insomnia. Due to the availability of over-the-counter products in some countries and the increasing use of me...
Source: Clinical Therapeutics - April 11, 2022 Category: Drugs & Pharmacology Authors: Natnicha Leelaviwat Poemlarp Mekraksakit Kristina M Cross Dylan M Landis Madison McLain Laveena Sehgal J Drew Payne Source Type: research

Relationship between pineal gland, sleep and melatonin in fibromyalgia women: a magnetic resonance imaging study
Acta Neuropsychiatr. 2021 Dec 14:1-9. doi: 10.1017/neu.2021.35. Online ahead of print.ABSTRACTA total of 80% of fibromyalgia (FM) population have reported poor sleep. In this regard, the pineal gland, involved in circadian rhythm processes as a key neuroendocrine organ which mainly synthesises and secretes melatonin, has never been studied before in this population. Therefore, this study aimed to evaluate the parenchyma pineal volume and its relation to sleep hours, sleep quality index and melatonin level at night. A total of 50 participants, 30 women with FM and 20 healthy control women underwent cranial magnetic resonanc...
Source: Acta Neuropsychiatrica - December 14, 2021 Category: Psychiatry Authors: Juan Luis Leon-Llamas Santos Villafaina Alvaro Murillo-Garcia Paloma Rohlfs Dom ínguez Narcis Gusi Source Type: research

Melatonin improves memory defects in a mouse model of multiple sclerosis by up-regulating cAMP-response element-binding protein and synapse-associated proteins in the prefrontal cortex.
Abstract Multiple sclerosis is a progressive autoimmune disorder of the myelin sheath and is the most common inflammatory disease of young adults. Up to 65% of multiple sclerosis patients have cognitive impairments such as memory loss and difficulty in understanding and maintaining attention and concentration. Many pharmacological interventions have been used to reverse motor impairments in multiple sclerosis patients; however, none of these drugs improve cognitive function. Melatonin can diffuse through the blood-brain barrier and has well-known antioxidant and anti-inflammatory properties with almost no side eff...
Source: Journal of Integrative Neuroscience - June 29, 2020 Category: Neuroscience Authors: Alghamdi BS, AboTaleb HA Tags: J Integr Neurosci Source Type: research

The use of melatonin in adult psychiatric disorders: Expert recommendations by the French institute of medical research on sleep (SFRMS).
Authors: Geoffroy PA, Micoulaud Franchi JA, Lopez R, Schroder CM, membres du consensus Mélatonine SFRMS Abstract Melatonin is a hormone secreted by the pineal gland at night. This hormone has many physiological functions, the main one being to synchronise individuals' biological rhythms. Exogenous melatonin has the same chronobiotic action, even at small doses (0.125mg). In addition, a sleep-inducing (soporific) action appears to occur in a dose-effect relationship, i.e. as the dose increases. In psychiatric disorders, these two effects could have interesting applications in clinical practice. The French institute...
Source: L Encephale - July 1, 2019 Category: Psychiatry Tags: Encephale Source Type: research

Melatonin is a biomarker of circadian dysregulation and is correlated with major depression and fibromyalgia symptom severity
Source: Journal of Pain Research - January 30, 2019 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Oral melatonin administration improves the objective and subjective sleep quality, increases 6-sulfatoxymelatonin levels and total antioxidant capacity in patients with fibromyalgia
ConclusionThe daily intake of melatonin improved the sleep quality, increased the aMT6-s levels and the total antioxidant capacity in patients with fibromyalgia.
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research

Combination pharmacotherapy for the treatment of fibromyalgia in adults.
CONCLUSIONS: There are few, large, high-quality trials comparing combination pharmacotherapy with monotherapy for fibromyalgia, consequently limiting evidence to support or refute the use of combination pharmacotherapy for fibromyalgia. PMID: 29457627 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 19, 2018 Category: General Medicine Authors: Thorpe J, Shum B, Moore RA, Wiffen PJ, Gilron I Tags: Cochrane Database Syst Rev Source Type: research

Oral melatonin administration improves the objective and subjective sleep quality, increases 6-sulfatoxymelatonin levels and total antioxidant capacity in patients with fibromyalgia
Conclusion The daily intake of melatonin improved the sleep quality, increased the aMT6-s levels and the total antioxidant capacity in patients with fibromyalgia.
Source: Journal of Applied Biomedicine - February 12, 2018 Category: Biotechnology Source Type: research

Trazodone for Insomnia: A Systematic Review
Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insomnia is an or...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research