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Total 43 results found since Jan 2013.

Acute Pain Management
This case-based session provided hospitalists with expert opinions and evidence-based approaches to navigate challenges when managing acute pain in the inpatient setting. Opioid prescription management can be especially problematic for hospitalists when caring for patients with chronic pain on long-term opiate therapy (LTOT) and those with opioid use disorder (OUD). Managing acute pain of the opiate-naïve patient in the inpatient setting There are multiple options in the hospitalist’s toolbox when managing acute pain in the inpatient setting. These include non-pharmacologic treatments and non-opioid and opioid pain medi...
Source: The Hospitalist - July 5, 2023 Category: Hospital Management Authors: Ronda Whitaker Tags: Clinical Guidelines Drug Therapy Opioid Resource Center Pain Source Type: research

Pharmacological management of fibromyalgia: a Bayesian network meta-analysis
Expert Rev Clin Pharmacol. 2022 Feb 23:1-10. doi: 10.1080/17512433.2022.2044792. Online ahead of print.ABSTRACTINTRODUCTION: The identification of the most effective therapy for patients with fibromyalgia (FM) remains controversial. Thus, we conducted a Bayesian network meta-analysis to compare several drugs employed as pharmacological management for FM.AREAS COVERED: The following databases were accessed in October 2021: PubMed, Google Scholar, Embase, and Scopus. All the randomized clinical trials (RCTs) that compare two or more pharmacological management for fibromyalgia were accessed. Only studies involving a minimum o...
Source: Pharmacological Reviews - February 21, 2022 Category: Drugs & Pharmacology Authors: Filippo Migliorini Nicola Maffulli J örg Eschweiler Matthias Knobe Markus Tingart Giorgia Colarossi Source Type: research

Complex Regional Pain Syndrome: A Comprehensive Review
In conclusion, CRPS is a multifactorial condition that still requires further studying to better understand its pathogenesis, epidemiology, genetic involvement, psychological implications, and treatment options. Future studies are warranted to better understand this syndrome. This will provide an opportunity for better prevention, diagnosis, and treatment of CRPS.PMID:34165690 | DOI:10.1007/s40122-021-00279-4
Source: Pain Physician - June 24, 2021 Category: Anesthesiology Authors: Samantha-Su Taylor Nazir Noor Ivan Urits Antonella Paladini Monica Sri Sandhu Clay Gibb Tyler Carlson Dariusz Myrcik Giustino Varrassi Omar Viswanath Source Type: research

Gabapentinoid Benefit and Risk Stratification: Mechanisms Over Myth
ConclusionsGabapentinoids remain a vital tool in the pain physician ’s multimodal armamentarium, but these drugs may not be effective in every clinical situation. Individuals with central sensitization and pain associated with slow-wave sleep deficits and potentially persons with comorbid addictions may benefit the most. The gabapentinoids appear to possess no add ictive potential on their own, based on laboratory and clinical data, but they may be abused by persons with opioid use disorders; consequently, cautious risk stratification must take place.
Source: Pain and Therapy - July 30, 2020 Category: Anesthesiology Source Type: research

The mirogabalin ALDAY phase 3 program in pain associated with fibromyalgia: the lessons learned.
Authors: Merante D Abstract Aims: The main aim of this work was to identify and to share the lessons learned from the negative outcome of the mirogabalin ALDAY phase 3 clinical program in pain associated with fibromyalgia. These lessons are important to improve planning and design of future phase 3 programs in fibromyalgia.Methods: A systematic review from Cochrane Library, Medline, Embase, clinicaltrials.gov, pharmaceutical companies and regulatory agencies' websites, was carried out starting from the development of gabapentin, the first α2δ ligand studied for the treatment of neuropathic pain and ending with th...
Source: Current Medical Research and Opinion - February 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia.
Abstract Fibromyalgia-associated chronic pain occurring without organic causes exerts negative effects on patients' quality of life, thereby necessitating the development of superior drugs. Since non-organic pain in patients with fibromyalgia occurs without external stimuli, an endpoint measure that reflects patients' spontaneous pain should be implemented in preclinical research. The present study is the first to apply the rat grimace scale (RGS), a facial expression-dependent measure developed for quantifying spontaneous pain, to the rat with reserpine-induced myalgia, an animal model of fibromyalgia exhibiting ...
Source: European Journal of Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Authors: Nagakura Y, Miwa M, Yoshida M, Miura R, Tanei S, Tsuji M, Takeda H Tags: Eur J Pharmacol Source Type: research

Analysis of the Cochrane Review: Pregabalin for Pain in Fibromyalgia in Adults. Cochrane Database Syst Rev. 2016;9:CD011790 and 2016;4:CD009002.
Authors: Ferreira-Dos-Santos G, Sousa DC, Costa J, Vaz-Carneiro A Abstract Fibromyalgia can be clinically defined by widespread pain lasting for longer than 3 months with tenderness on palpation in 11 or more of 18 specified tender points. Many people with fibromyalgia are significantly disabled, and experience moderate to severe pain for many years, for which conventional analgesics are usually not effective. For these patients treatment options generally include antidepressants like tricyclic agents, serotonin and noradrenaline reuptake inhibitors, or anticonvulsants like pregabalin or gabapentin. Pregabalin is a...
Source: Acta Medica Portuguesa - September 8, 2018 Category: General Medicine Tags: Acta Med Port Source Type: research

Sexual Dysfunctions Induced by Pregabalin
Conclusions In this case series, SDs were noticed with PGB in 41.33% (n = 31) (men, 13 [50%]; women, 18 [36.73%]), which included erectile dysfunction (n = 16, 51.61%), anorgasmia (n = 10, 32.26%), and loss of libido (n = 11, 35.48%). Sexual dysfunctions occurred within weeks after the use of PGB and were not dose related. They occurred with low therapeutic PGB doses (50–100 mg/d). Discontinuation of PGB resulted in improvement of SDs within weeks. To conclude, SDs are not infrequent adverse effects of PGB therapy. Pregabalin can induce erectile dysfunction, loss of libido, and anorgasmia. Sexual dysfunctions induced b...
Source: Clinical Neuropharmacology - July 1, 2018 Category: Neurology Tags: Original Articles Source Type: research

Fibromyalgia Symptoms Reduced by Osteopathic Manipulative Medicine and Gabapentin.
Authors: King HH PMID: 29710361 [PubMed - in process]
Source: Journal of the American Osteopathic Association - May 2, 2018 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research