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Do psychedelics treat chronic pain or is it the placebo effect?
Preliminary studies show that psilocybin, a compound in magic mushrooms, reduces pain in people with chronic Lyme disease, fibromyalgia and migraines. But without effective control groups the evidence is far from conclusive
Source: New Scientist - Health - July 12, 2023 Category: Consumer Health News Source Type: research

Prediction model for juvenile idiopathic arthritis: challenges and opportunities
Acute and chronic musculoskeletal pain is a common reason for referral to the pediatric rheumatologist. (1,2,3) The differential diagnosis is extensive; patients may be diagnosed with inflammatory joint pain, includingjuvenile idiopathic arthritis (JIA), arthritis related to infection (e.g.: reactive arthritis – including rheumatic fever and post-strep, viral arthritis, Lyme disease) and other autoimmune and inflammatory disorders such as systemic lupus erythematosus; painful non-inflammatory MSK disorders include overuse injuries (e.g.: patellofemoral pain syndrome (PFPS)), osteochondroses (i.e.: Osgoo d-Schlatter disea...
Source: The Journal of Pediatrics - August 4, 2022 Category: Pediatrics Authors: Jennifer E. Weiss Tags: Editorials Source Type: research

Oral small fiber neuropathy in lyme disease: is botulinum toxin type-a a therapeutic option in its management? —a case report
Small fiber neuropathy (SFN) has been associated with posttreatment Lyme disease syndrome (PTLDS), a chronic widespread pain condition with an enormous impact on quality of life. SFN has been associated with hyperalgesia and allodynia, as seen in fibromyalgia. In PTLDS, peripheral and central pain mechanisms involving SFN are likely present, with neuropeptide imbalance, leading to increased nociceptive signaling. Refractory SFN cases are challenging to manage, and Botulinum toxin type-A (BTX-A) could be a treatment option with long-lasting results and fewer side effects.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 15, 2022 Category: ENT & OMF Authors: Luiz Claudio Viegas Costa, Pallavi Parashar, Reid Friesen Source Type: research

Characterising DSCATT: A case series of Australian patients with debilitating symptom complexes attributed to ticks
CONCLUSION: This is the first case series of patients with Debilitating Symptom Complexes Attributed to Ticks. They had high rates of other medically unexplained syndromes, and no evidence of acute Lyme disease, or any common organic disease process. Debilitating Symptom Complexes Attributed to Ticks remains medically unexplained, and may therefore be due to an as yet unidentified cause, or may be considered a medically unexplained syndrome similar to conditions such as chronic fatigue syndrome.PMID:34465249 | DOI:10.1177/00048674211043788
Source: The Australian and New Zealand Journal of Psychiatry - September 1, 2021 Category: Psychiatry Authors: Jesse Schnall Georgina Oliver Sabine Braat Richard Macdonell Katherine B Gibney Richard A Kanaan Source Type: research

Lyme Disease in Humans.
Abstract Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread throughout the Northern Hemisphere, continues to increase globally due to multiple environmental factors, coupled with increased incursion of humans into habitats that harbor the spirochete. B. burgdorferi sensu lato is transmitted by ticks from the Ixodes ricinus complex. In North America, B. burgdorferi causes nearly all infections; in Europe, B. afzelii and B. garinii are most associated with human disease. The spirochete's unusua...
Source: Current Issues in Molecular Biology - December 11, 2020 Category: Molecular Biology Authors: Radolf- JD, Strle K, Lemieux JE, Strle F Tags: Curr Issues Mol Biol Source Type: research

Infections Preceding the Development of Dercum disease
Publication date: Available online 19 December 2019Source: IDCasesAuthor(s): Karen Beltran, Rita Wadeea, Karen L. HerbstABSTRACTDercum Disease (DD) is a rare inflammatory disease of painful subcutaneous fat masses with known alterations in lymphatic vessels. DD masses vary from pearl to walnut-size or larger and occur anywhere in body fat. Signs and symptoms of DD are similar to fibromyalgia. While the etiology of DD is unknown, metabolic, autoimmune, or autosomal genetic transmission has been proposed. This series presents 7 cases where DD followed an infection either histoplasmosis, coccidioidomycosis or Lyme disease. Kn...
Source: IDCases - December 19, 2019 Category: Infectious Diseases Source Type: research

The Cerebrospinal Fluid in Multiple Sclerosis
Conclusions OCB are important biomarkers that can support MRI diagnostics and help to avoid false-positive MS diagnoses. Therefore, the revised McDonalds criteria have increased the importance of the OCB. New biomarkers such as AQP4 have now established themselves in clinical practice, and others such as Anti-MOG and NfL are about to enter clinical routine. An important focus in the search for new biomarkers is the monitoring of therapy efficacy and the prediction of severe side effects. Many other CSF molecules such as CHI3L1, IL-6, or CXCL13 show potential as markers for clinical practice, but further research is nee...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Treat the Patient, Not the Label: A Pain Neuroscience Update
When dealing with chronic pain, it is often not possible for clinicians to provide adequate answers to their patients about what might be wrong, and why they continue to have their pain. This has led to greater use of diagnostic “labels” for conditions such as fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, chronic Lyme disease, and many others. Assigning such “labels” to patients with chronic pain has far-reaching consequences for all stakeholders. The aim of this clinical commentary is to highlight some of the common threads among 4 particular conditions common to women—fibromyalgia, chronic f...
Source: Journal of Women�s Health Physical Therapy - April 1, 2019 Category: Physiotherapy Tags: Clinical Commentary Source Type: research

Management of patients presenting with generalized musculoskeletal pain and a suspicion of Lyme disease.
Authors: Ranque-Garnier S, Eldin C, Sault C, Raoult D, Donnet A Abstract Lyme disease is caused by bacteria of the B. burgdorferi sensu lato complex, and can give polymorphic clinical manifestations that can affect several organs such as the skin, the central nervous system, or the joints. In recent years, patients' associations and physicians have been supporting the hypothesis that this infection would manifest as chronic generalized musculoskeletal pain symptoms, named "chronic Lyme disease". Fibromyalgia is a clinical presentation characterized by chronic generalized musculoskeletal pain with a major impact on...
Source: Medecine et Maladies Infectieuses - February 16, 2019 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

A tiny tick can cause a big health problem
We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination. The ticks were firmly latched on to the skin and careful removal prevented incarceration of the mouth parts. Rickettsial diseases that were believed to have disappeared from India are reemerging and their presence has recently been documented in at least 11 states in the country. Among vector borne diseases, the most common, Lyme disease, also known ...
Source: Indian Journal of Ophthalmology - November 13, 2017 Category: Opthalmology Authors: Manuel John M Raman Keith Ryan Source Type: research

Canadian Rheumatology Association Meeting, The Westin Ottawa, Ottawa, Ontario, Canada, February 8-11, 2017.
Authors: Silverman ED Abstract The 72nd Annual Meeting of The Canadian Rheumatology Association (CRA) was held at The Westin Ottawa, Ottawa, Ontario, Canada, February 8-11, 2017. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2017 award winners: Dr. Vinod Chandran, Young Investigator; Dr. Jacques P. Brown, Distinguished Investigator; Dr. David Robinson, Teacher-Educator; Dr. Michel Zummer, Distinguished Rheumatologist; Ms. Rebecca Gole, Best Abstract on SLE Research by a Trainee - Ian Watson Award; Ms. Bailey Russell...
Source: Journal of Rheumatology - May 4, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Characteristics of seroconversion and implications for diagnosis of post-treatment Lyme disease syndrome: acute and convalescent serology among a prospective cohort of early Lyme disease patients
Abstract Two-tier serology is often used to confirm a diagnosis of Lyme disease. One hundred and four patients with physician diagnosed erythema migrans rashes had blood samples taken before and after 3 weeks of doxycycline treatment for early Lyme disease. Acute and convalescent serologies for Borrelia burgdorferi were interpreted according to the 2-tier antibody testing criteria proposed by the Centers for Disease Control and Prevention. Serostatus was compared across several clinical and demographic variables both pre- and post-treatment. Forty-one patients (39.4 %) were seronegative both before and after tr...
Source: Clinical Rheumatology - March 1, 2015 Category: Rheumatology Source Type: research

Brief Report: Long‐Term Assessment of Fibromyalgia in Patients With Culture‐Confirmed Lyme Disease
ConclusionFibromyalgia was observed in only 1% of 100 patients with culture‐confirmed early Lyme disease; this frequency is consistent with that observed in the general population.
Source: Arthritis and Rheumatism - February 25, 2015 Category: Rheumatology Authors: Gary P. Wormser, Erica Weitzner, Donna McKenna, Robert B. Nadelman, Carol Scavarda, Shimon Farber, Priya Prakash, Julia Ash, John Nowakowski Tags: Lyme Disease Source Type: research

Long‐Term Assessment of Fibromyalgia in Patients with Culture‐Confirmed Lyme Disease
Conclusions: Fibromyalgia was observed in only 1% of 100 patients with culture‐confirmed early Lyme disease, a frequency consistent with that found for the general population. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 2, 2014 Category: Rheumatology Authors: Gary P. Wormser, Erica Weitzner, Donna McKenna, Robert B. Nadelman, Carol Scavarda, Shimon Farber, Priya Prakash, Julia Ash, John Nowakowski Tags: Brief Report Source Type: research

Letter From the Editor: The Great Mimickers in Radiology
Many diseases have been referred to as “great imitator” or “great mimicker.” For the sake of accuracy, I looked up the definition in The Dictionary of Modern Medicine (JC. Segen, CRC Press; 1992): “The great imitator is a phrase used for medical conditions that feature nonspecific symptoms and may be confused with a number of other diseases. Most great imitators are systemic in nature.” The list of diseases referenced is pretty long and includes approximately 15 entities, among which are quite a few that we, radiologists, rarely encounter as the diseases do not exhibit abnormal imaging findings (e.g., Lyme dise...
Source: Seminars in Ultrasound CT and MRI - March 6, 2014 Category: Radiology Authors: Gabriela Gayer Source Type: research