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Total 37 results found since Jan 2013.

Involvement of ASIC3 and substance P in therapeutic ultrasound-mediated analgesia in mouse models of fibromyalgia
Therapeutic ultrasound (tUS) is widely used in chronic muscle pain control. However, its analgesic molecular mechanism is still not known. Our objective is to reveal the mechanism of the tUS-induced analgesia in mouse models of fibromyalgia. We applied tUS in mice that have developed chronic hyperalgesia induced by intramuscular acidification and determined the tUS frequency at 3MHz, dosage at 1W/cm2 (measured output as 6.3 mW/cm2) and 100% duty cycle for 3 min having the best analgesic effect. Pharmacological and genetic approaches were used to probe the molecular determinants involved in tUS-mediated analgesia.
Source: The Journal of Pain - April 11, 2023 Category: Materials Science Authors: Der-Sheng Han, Chen-Han Lee, Yih-Dar Shieh, Ke-Vin Chang, Shing-Hong Lin, Ya-Cherng Chu, Jaw-Lin Wang, Chih-Cheng Chen Source Type: research

Involvement of ASIC3 and Substance P in Therapeutic Ultrasound –Mediated Analgesia in Mouse Models of Fibromyalgia
Therapeutic ultrasound (tUS) is widely used in chronic muscle pain control. However, its analgesic molecular mechanism is still not known. Our objective is to reveal the mechanism of the tUS-induced analgesia in mouse models of fibromyalgia. We applied tUS in mice that have developed chronic hyperalgesia induced by intramuscular acidification and determined the tUS frequency at 3  MHz, dosage at 1 W/cm2 (measured output as 6.3 mW/cm2) and 100% duty cycle for 3 minutes having the best analgesic effect.
Source: The Journal of Pain - April 11, 2023 Category: Materials Science Authors: Der-Sheng Han, Cheng-Han Lee, Yih-Dar Shieh, Ke-Vin Chang, Shing-Hong Lin, Ya-Cherng Chu, Jaw-Lin Wang, Chih-Cheng Chen Tags: Original Reports Source Type: research

Improved diagnostic performance of CASPAR criteria with integration of ultrasound
ConclusionThe diagnostic utility of the CASPAR was improved by integrating tenosynovitis and/or enthesitis when using US. US provides additional value for PsA recognition.
Source: Frontiers in Immunology - October 10, 2022 Category: Allergy & Immunology Source Type: research

Role of ultrasound for assessment of psoriatic arthritis patients with fibromyalgia
Conclusions US has significantly greater value than composite clinical scores in the assessment of disease activity in PsA patients with FMS.
Source: Annals of the Rheumatic Diseases - November 12, 2021 Category: Rheumatology Authors: Polachek, A., Furer, V., Zureik, M., Nevo, S., Mendel, L., Levartovsky, D., Wollman, J., Aloush, V., Tzemach, R., Elalouf, O., Anouk, M., Berman, M., Kaufman, I., Carmi, O., Lahat, Y., Eviatar, T., Padova, H., Sarbagil-Maman, H., Borok, S., Broyde, A., Ed Tags: ARD, Psoriatic arthritis Source Type: research

P022  Audit of musculoskeletal ultrasound to optimise DMARD therapy among patients in a district general hospital
Conclusion MSUS avoided unnecessary DMARD escalation in a significant proportion of patients with inflammatory arthritis and features of concomitant chronic pain and/or fibromyalgia (n = 26, 37%), potentially resulting in reduced patient exposure to harmful DMARD side effects, and cost savings for the servi ce.Disclosure M. Chen-Xu: None.D. Hyseni: None.K. Achilleos: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Ultrasound to identify SLE patients with musculoskeletal symptoms who respond best to therapy: The USEFUL longitudinal multicentre study
CONCLUSIONS: In SLE patients without fibromyalgia, those with positive ultrasound had better clinical response to therapy. Imaging-detected synovitis/tenosynovitis may be considered to decide on therapy and enrich clinical trials.PMID:33792659 | DOI:10.1093/rheumatology/keab288
Source: Pain Physician - April 1, 2021 Category: Anesthesiology Authors: Khaled Mahmoud Ahmed S Zayat Md Yuzaiful Md Yusof Katherine Dutton Lee Suan Teh Chee-Seng Yee David D'Cruz Nora Ng David Isenberg Coziana Ciurtin Philip G Conaghan Paul Emery Christopher J Edwards Elizabeth M A Hensor Edward M Vital Source Type: research

Neuropathic pain features suggestive of small fiber neuropathy in fibromyalgia syndrome: a clinical and ultrasonographic study on female patients
CONCLUSIONS: Screening tools have a good concordance in identifying neuropathic pain features suggestive of SFN in FM patients, although a better performance is provided by DN4. Determining the CSA sural nerve with an ultrasound examination may provide some information about the possible presence of SFN.PMID:33666162
Source: Clinical and Experimental Rheumatology - March 5, 2021 Category: Rheumatology Authors: Marco Di Carlo Pietro Cesaroni Fausto Salaffi Source Type: research

Chronic Musculoskeletal Pain: Nonpharmacologic, Noninvasive Treatments.
Abstract Chronic low back pain, neck pain, hip and knee osteoarthritis, and fibromyalgia are the most common types of chronic musculoskeletal pain. Because no individual therapy has consistent benefit, a multimodal treatment approach to chronic musculoskeletal pain is recommended. Many nonpharmacologic, noninvasive treatment approaches yield small to moderate improvement and can be used with pharmacologic or more invasive modalities. Systematic reviews and guidelines support the effectiveness of various forms of exercise in improving pain and function in patients with chronic pain. Cognitive behavior therapy and m...
Source: American Family Physician - October 15, 2020 Category: Primary Care Authors: Flynn DM Tags: Am Fam Physician Source Type: research

IJERPH, Vol. 17, Pages 4611: Effects of Manual Therapy on Fatigue, Pain, and Psychological Aspects in Women with Fibromyalgia
ríguez Fibromyalgia is a condition characterised by chronic widespread muscle pain and fatigue, sleep disturbances, cognitive disorders, and mood disturbance. The purpose of this study was to determine the effectiveness of a manual therapy technique performed with moderate digital pressure in women with fibromyalgia (n = 24). In this randomised, controlled trial, the participants were randomly assigned to the experimental group or placebo group. The experimental group was assisted with manual therapy sessions based on connective tissue massage, whereas the placebo group was “treated” with u...
Source: International Journal of Environmental Research and Public Health - June 25, 2020 Category: Environmental Health Authors: Nadal-Nicol ás Rubio-Arias Mart ínez-Olcina Reche-Garc ía Hern ández-García Mart ínez-Rodríguez Tags: Article Source Type: research

New Developments in Non-invasive Brain Stimulation in Chronic Pain
This article reviews the current evidence for the use of transcranial direct current (tDCS) and repetitive transcranial magnetic stimulation (rTMS) to improve outcomes in chronic pain. Finally, we introduce the reader to novel stimulation methods that may improve therapeutic outcomes in chronic pain.Recent FindingsWhile tDCS is approved for treatment of fibromyalgia in Canada and the European Union, no NIBS method is currently approved for chronic pain in the USA. Increasing sample sizes in randomized clinical trials (RCTs) seems the most efficient way to increase confidence in initial promising results. Trends at funding ...
Source: Current Physical Medicine and Rehabilitation Reports - May 10, 2020 Category: Rehabilitation Source Type: research

Machine Learning Diagnostic Modeling for Classifying Fibromyalgia Using B-mode Ultrasound Images.
Authors: Behr M, Saiel S, Evans V, Kumbhare D Abstract Fibromyalgia (FM) diagnosis remains a challenge for clinicians due to a lack of objective diagnostic tools. One proposed solution is the use of quantitative ultrasound (US) techniques, such as image texture analysis, which has demonstrated discriminatory capabilities with other chronic pain conditions. From this, we propose the use of image texture variables to construct and compare two machine learning models (support vector machine [SVM] and logistic regression) for differentiating between the trapezius muscle in healthy and FM patients. US videos of the righ...
Source: Ultrasonic Imaging - March 18, 2020 Category: Radiology Tags: Ultrason Imaging Source Type: research

Microangiopathy and forearm arterial blood flow in systemic sclerosis: a controlled study
ConclusionsOur study demonstrated a high prevalence of macrovascular disease in SSc; no correlation was found between microvasculopathy and macrovascular disease, suggesting that different pathogenic mechanisms might operate in different vessels size.Key Points• This study demonstrated a high prevalence of macrovascular arterial forearm disease in systemic sclerosis patients.• This study found no correlation between capillaroscopic microangiopathy evolution score (MES) and macrovascular abnormalities.• Our findings suggest that different pathogenic mechanisms might operate in different vessels size.
Source: Clinical Rheumatology - March 9, 2020 Category: Rheumatology Source Type: research