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Arthroscopic rotator cuff repair in fibromyalgia patients had comparable outcomes to a matched control group
ConclusionFibromyalgia patients with rotator cuff tears who undergo ARCR do not have inferior patient-reported outcomes compared with non-fibromyalgia controls. Fibromyalgia should not be a considered a contraindication for ARCR.Level of evidence: III
Source: Journal of Orthopaedics and Traumatology - May 11, 2023 Category: Orthopaedics Source Type: research

A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain
This study suggests a possible mechanism of action of dextrose prolotherapy in noninflammatory muscle pain such as fibromyalgia and provides insights into treating other types of chronic pain.
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

IJERPH, Vol. 18, Pages 12021: Fibromyalgia: Evidence for Deficits in Positive Psychology Resources. A Case-Control Study from the Al- Ándalus Project
IJERPH, Vol. 18, Pages 12021: Fibromyalgia: Evidence for Deficits in Positive Psychology Resources. A Case-Control Study from the Al-Ándalus Project International Journal of Environmental Research and Public Health doi: 10.3390/ijerph182212021 Authors: Manuel Javier Arrayás-Grajera Inmaculada Tornero-Quiñones Blanca Gavilán-Carrera Octavio Luque-Reca Cecilia Peñacoba-Puente Ángela Sierra-Robles Ana Carbonell-Baeza Fernando Estévez-López Positive psychology is the study of positive subjective experience and individual traits. Identifying deficits in positive psychology regarding fibromyalgia ma...
Source: International Journal of Environmental Research and Public Health - November 16, 2021 Category: Environmental Health Authors: Manuel Javier Array ás-Grajera Inmaculada Tornero-Qui ñones Blanca Gavil án-Carrera Octavio Luque-Reca Cecilia Pe ñacoba-Puente Ángela Sierra-Robles Ana Carbonell-Baeza Fernando Est évez-López Tags: Article Source Type: research

Mitochondrial DNA Copy Number and Damage in People with HIV and Chronic Pain
Mitochondrial DNA (mtDNA) is integral to mitochondrial function and cellular energy production. Lack of protective histones and limited repair capacity make mtDNA fragile and susceptible to injury. HIV infection and antiretroviral therapy is associated with mitochondrial depletion and damage, likely due to oxidative stress. Mitochondrial damage has been implicated in widespread musculoskeletal pain among people with Fibromyalgia. Whether mtDNA depletion and damage is associated with chronic pain in people with HIV has not yet been addressed.
Source: The Journal of Pain - May 1, 2021 Category: Materials Science Authors: Shannon Gilstrap, Joanna Hobson, Michael Owens, Dyan White, Melissa Sammy, Scott Ballinger, Burel Goodin Source Type: research

An unusual complication following Sacrospinous Fixation for Vaginal Vault Prolapse
A 74-years-old woman presented with recurrent apical prolapse (POPQ stage 3). Previous surgical history includes abdominal hysterectomy for menorrhagia and posterior repair with sacrospinous fixation (SSF) for vault prolapse. She was unsuitable for a mesh-based abdominal sacrocolpopexy due to fibromyalgia and chronic pain syndrome, and underwent vaginal repair with SSF. Dissection during surgery was difficult due to scarring. On 1  st postoperative day, she had a syncopal episode. Blood results revealed a significant drop in her haemoglobin (120 g/L to 88 g/L) and hyponatremia (123 mmol/L) that was corrected gradually.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 9, 2021 Category: OBGYN Authors: Vandna Verma, Kristina Savickaite, Smita Rajshekhar, Ashish Pradhan Tags: Short communication Source Type: research

The Cerebrospinal Fluid in Multiple Sclerosis
Conclusions OCB are important biomarkers that can support MRI diagnostics and help to avoid false-positive MS diagnoses. Therefore, the revised McDonalds criteria have increased the importance of the OCB. New biomarkers such as AQP4 have now established themselves in clinical practice, and others such as Anti-MOG and NfL are about to enter clinical routine. An important focus in the search for new biomarkers is the monitoring of therapy efficacy and the prediction of severe side effects. Many other CSF molecules such as CHI3L1, IL-6, or CXCL13 show potential as markers for clinical practice, but further research is nee...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Epigenetics insights into chronic pain: DNA hypomethylation in fibromyalgia—a controlled pilot-study
Abstract: To evaluate changes in DNA methylation profiles in patients with fibromyalgia (FM) compared to matched healthy controls (HCs). All individuals underwent full clinical and neurophysiological assessment by cortical excitability (CE) parameters measured by transcranial magnetic stimulation. DNA from the peripheral blood of patients with FM (n = 24) and HC (n = 24) were assessed using the Illumina-HumanMethylation450 BeadChips. We identified 1610 differentially methylated positions (DMPs) in patients with FM displaying a nonrandom distribution in regions of the genome. Sixty-nine percent of DMP in FM were hypomethyla...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Transabdominal midline reconstruction by minimally invasive surgery: technique and results
Conclusion Although the study involved a small number of patients, it has proved the technique to be feasible, easy to perform, and have the combined benefits of laparoscopic and open surgery. The results, shown by CT-scan, peri-operative, and QOL findings, were good.
Source: Hernia - January 22, 2016 Category: Sports Medicine Source Type: research

Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia
Exercise intolerance, as evidenced by a worsening of pain, fatigue, and stiffness after novel exertion, is a key feature of fibromyalgia (FM). In this pilot study, we investigate whether; insufficient muscle repair processes and impaired anti-inflammatory mechanisms result in an exaggerated pro-inflammatory cytokine response to exhaustive exercise, and consequently a worsening of muscle pain, stiffness and fatigue in the days post-exercise. We measured changes in muscle pain and tenderness, fatigue, stiffness, and serum levels of neuroendocrine and inflammatory cytokine markers in 20 women with FM and 16 healthy controls (...
Source: Journal of Neuroimmunology - October 17, 2014 Category: Allergy & Immunology Authors: Britta Torgrimson-Ojerio, Rebecca L. Ross, Nathan F. Dieckmann, Stephanie Avery, Robert M. Bennett, Kim D. Jones, Anthony J. Guarino, Lisa J. Wood Source Type: research

Targeting cortical representations in the treatment of chronic pain: a review. Moseley GL, Flor H. Neurorehabil Neural Repair 2012;26(6):646–52. Epub 2012 Feb 13.
Recent neuroscientific evidence has confirmed the important role of cognitive and behavioral factors in the development and treatment of chronic pain. Neuropathic and musculoskeletal pain are associated with substantial reorganization of the primary somatosensory and motor cortices as well as regions such as the anterior cingulate cortex and insula. What is more, in patients with chronic low back pain and fibromyalgia, the amount of reorganizational change increases with chronicity; in phantom limb pain and other neuropathic pain syndromes, cortical reorganization correlates with the magnitude of pain. These findings have ...
Source: The Spine Journal - April 1, 2013 Category: Orthopaedics Tags: Journal Reports Source Type: research