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Specialty: Drugs & Pharmacology
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Total 194 results found since Jan 2013.
Rozanolixizumab: First Approval
This article summarizes the milestones in the development of rozanolixizumab leading to this first approval for the treatment of gMG in adults who are anti-AChR or anti-MuSK antibody positive.
Source: Drugs - September 1, 2023 Category: Drugs & Pharmacology Source Type: research
Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances
This study systematically examines the antidepressant effects of coumarins and their derivatives in relation to time series of research progress in the pharmacological pathways, association with other diseases, toxicity and bliometric analysis. The review was approached using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) coupled with R package using Biblioshiny, a web interface for Bibliometrix analysis and VOSviewer software analytic tools. Literature searches were conducted in Scopus, Web of Science, and PubMed from the inception through January 21, 2023. Coumarins, depression, coumarin ...
Source: European Journal of Pharmacology - August 5, 2023 Category: Drugs & Pharmacology Authors: Nneka Augustina Akwu Makhotso Lekhooa Dou Deqiang Adeyemi Oladapo Aremu Source Type: research
What is the progress of experimental drug development for fibromyalgia?
Expert Opin Investig Drugs. 2023 Jun 26. doi: 10.1080/13543784.2023.2230118. Online ahead of print.NO ABSTRACTPMID:37357750 | DOI:10.1080/13543784.2023.2230118
Source: Expert Opinion on Investigational Drugs - June 26, 2023 Category: Drugs & Pharmacology Authors: Kim Lawson Source Type: research
Evaluation of neutrophil-lymphocyte ratio, lymphocyte-monocyte, and monocyte-high density lipoprotein ratios in patients with fibromyalgia and determination of their relationship with disease activity, pain, and depression levels
CONCLUSIONS: This study shows that in fibromyalgia patients, monocyte level and MHR were higher than in healthy subjects. Also, high-density lipoprotein-cholesterol (HDL-C) level was found lower, and the total cholesterol level was found higher in patients with FM. Increased LMR and HDL-C values were found as responsible for decreasing the risk of developing FM and increased glucose and total cholesterol values were responsible for increasing the risk of FM developing.PMID:37318466 | DOI:10.26355/eurrev_202306_32609
Source: European Review for Medical and Pharmacological Sciences - June 15, 2023 Category: Drugs & Pharmacology Authors: A G Do ğan Source Type: research
Targeting α7-nAChR by galantamine mitigates reserpine-induced fibromyalgia-like symptoms in rats: Involvement of cAMP/PKA, PI3K/AKT, and M1/M2 microglia polarization
Eur J Pharmacol. 2023 May 26:175810. doi: 10.1016/j.ejphar.2023.175810. Online ahead of print.ABSTRACTFibromyalgia (FM) is a pain disorder marked by generalized musculoskeletal pain accompanied by depression, fatigue, and sleep disturbances. Galantamine (Gal) is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs) and a reversible inhibitor of cholinesterase. The current study aimed to explore the therapeutic potential of Gal against reserpine (Res)-induced FM-like condition along with investigating the α7-nAChR's role in Gal-mediated effects. Rats were injected with Res (1 mg/kg/day; sc)...
Source: European Journal of Pharmacology - May 28, 2023 Category: Drugs & Pharmacology Authors: Ahd A Atta Weam W Ibrahim Ahmed F Mohamed Noha F Abdelkader Source Type: research
Sj ögren’s syndrome
AbstractSj ögren’s syndrome (SS) is characterised as keratoconjunctivitis sicca (dry eyes), xerostomia (dry mouth) commonly associated with salivary gland enlargement, and is referred to as Primary Sjögren’s syndrome. It is known as Secondary Sjögren’s syndrome when it occurs in patients, with connect ive tissue disease, such as rheumatoid arthritis, systemic lupus erythematosus, polyarthritis nodosa, polymyositis, and systemic sclerosis. SS has also been associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation, human immunodeficiency syndrome (AIDS), hepatit is C infection (H...
Source: Inflammopharmacology - May 17, 2023 Category: Drugs & Pharmacology Source Type: research
