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THCB 20th Birthday Classic:  As I’ve always suspected, Health Care = Communism + Frappuccinos
By MATTHEW HOLT Our 20th birthday continues with a few classics coming out. Back in 2005 I was really cutting a lyrical rug, and would never miss a chance to get that Cambridge training in Marxism into use. This essay about whether health care should be a public or private good has always been one of my favorites, even if I’m not sure Starbucks is still making Frappuccinos. And 18 years later the basic point of this essay remains true, even if many of you will not have a clue who Vioxx or Haliburton were or why they mattered back then! Those of you who think I’m an unreconstructed commie will correctly suspec...
Source: The Health Care Blog - August 15, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Matthew Holt Communism Frappuccinos Source Type: blogs

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Opinion Piece from Pharmacists United for Truth & Transparency ( " PUTT " )
Pharmacists United for Truth& Transparency ( " PUTT " ) is a non-profit advocacy organization founded by independent pharmacists and pharmacy owners devoted to exposing what they describe as anti-competitive tactics deployed by the largest Pharmacy Benefit Managers (PBMs - aka Pharmacy Benefit Companies or PBCs as the trade organization known as the Pharmaceutical Care Management Association or PCMA has tried to rebrand its industry since the acronym PBM has become toxic) recently published an opinion piece with an interesting title: " The Deadliest Addiction in the U.S. Isn ' t What You Think It Is " (read it athttps:...
Source: Scott's Web Log - July 12, 2023 Category: Endocrinology Tags: 2023 drug prices PBM Pharmacists United for Truth & Transparency PUTT Source Type: blogs

Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species. We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Immunotherapy Implant to Treat Pancreatic Cancer
Researchers at Houston Methodist have developed an implant that can provide localized and sustained release of immunotherapies to treat pancreatic cancer. Their device is tiny, at approximately the size of a grain of rice, and they have termed it a &...
Source: Medgadget - May 8, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology Urology HoustonMethodist prostate CA prostate cancer Source Type: blogs

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Aging as a Disease: a Zoo Contains Animals, But is Not Itself an Animal
The author of today's open access commentary is quite prolifically opinionated on the topic of mTOR and its status as a central pillar of programmed aging, particularly the hyperfunction version of programmed aging theories. Nonetheless, he sometimes has interesting things to say, as is the case here on the topic of whether aging is a disease. A great deal of ink has been spilled of late on the question of whether or not aging is a disease. This is the case not because everyone suddenly developed an interest in semantics, but rather because it directly affects the regulation of medical development, and thus the flow of fun...
Source: Fight Aging! - February 6, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Ultrasound is Ultra-Cool
This study is also a major step forward for the exciting possibility of combining focused ultrasound with targeted delivery of medications or antibodies that normally have limited capability to cross the blood brain barrier from the blood to the brain.”  Similarly, researchers at Yonsei University College of Medicine (South Korea) found that focused ultrasound improved the delivery of Alzheimer’s drugs by over eight times.  “While there is no complete cure for dementia, we hope that open BBB [blood brain barrier] surgery using FUS surgery can help give hope to dementia patients,” the lead researcher said. ...
Source: The Health Care Blog - January 25, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech 3D printing ChatGPT DSP Kim Bellard Ultrasound Source Type: blogs

Evidence based medicine and politics
I ' m not sure if you can read this -- I have a cookie that gives me access, but the URL doesn ' t include the proxy server and it appears to be accessible. Let me know. Anyway, it ' sa discussion in NEJM of the U.S. Preventive Services Task Force. The USPSTF is a panel of clinical experts convened by the Agency for Healthcare Research and Quality, AHRQ, which is usually pronounced like ark. It draws on available research to evaluate screening tests and preventive interventions. An A or B grade means they recommend it. A C grade means it might be worthwhile for some people, but you should discuss it with your doctor and ma...
Source: Stayin' Alive - January 5, 2023 Category: American Health Source Type: blogs

Fight Aging! Newsletter, October 24th 2022
This study shows the uncoupling of lifespan and healthspan parameters (aerobic fitness and spontaneous activity) and provides new insights into SIRT3 function in CR adaptation, fuel utilization, and aging. HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People https://www.fightaging.org/archives/2022/10/hdl-level-age-and-smoking-are-the-largest-determinants-of-mortality-risk-in-old-people/ An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise ...
Source: Fight Aging! - October 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
September 01, 2022 Edition-----This week it is all about weather and climate change with floods, heatwaves and droughts in Parkistan, Europe and China. In the US drought is causing all sorts of food supply issues and price rises.In the EU was a seeing all sorts of energy supply problems.In Australia we have a feast of investigations into ScoMo, RoboDebt and so on. Lots to browse!-----Major Issues.-----https://www.afr.com/policy/foreign-affairs/us-alliance-fear-that-dare-not-speak-its-name-20220818-p5bat8US alliance fear that dare not speak its nameUneasiness about divided, inward-looking America fulfilling its security gua...
Source: Australian Health Information Technology - September 1, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Weekly Overseas Health IT Links –20th August 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://www.digitalhealth.net/2022/08/ai-predictive-trial-staffordshire-hn-reduce-ae-admissions/AI predictive trial in Staffordshire reduces A&E admissions by 35%A trial which looked at how existing patient data could be used to predict those most likely to need hospital care has led to a 35% reduction on average in A&E attendances across Staffordshire.Jor...
Source: Australian Health Information Technology - August 20, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How IoT Medical Devices Save and Improve Lives
The following is a guest article by Erik Kling, Interim Head of IoT Americas at Vodafone Business. IoT, or the Internet of Things, has transformed our homes with connected lights and smart appliances. It’s also revolutionized all areas of business, including manufacturing. Sensors connected to the internet can track goods throughout the supply chain — from sourcing materials to delivering completed products to consumers. IoT technology has improved the way we live, but its most profound impact may be in healthcare, where it’s saving lives and improving health. Before IoT revolutionized healthcare, doctors and care pr...
Source: EMR and HIPAA - June 23, 2022 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Clinical Health IT Company Healthcare IT IT Infrastructure and Dev Ops AED American College of Cardiology Connected Defibrillators Continuous Glucose Monitors CPAP Dr. Ami Bhatt Elliot Erik Kling Healthcare AI Source Type: blogs

Fight Aging! Newsletter, May 16th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 15, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs