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Total 1284 results found since Jan 2013.
Judge for yourself the management of this patient with " NSTEMI, multivessel disease "
DISCUSSION:The administration of
opioid analgesia prior to cath in patients with concern for ACS is associated
with longer door-to-balloon times, and greater peak troponin levels. The rate
of Occlusion MI in those who received pre-cath opioids was double the rate of
those without pre-cath opioids, and STEMI(-) OMI patients who received pre-cath
opioids waited 10 hours on average longer to get cath than those who did not
received opioids. These results add support to our hypothesis that a major
mechanism of harm caused by opioid medications in ACS patients involves delays
to the cath lab for patients with STEMI(-) OMI.=====...
Source: Dr. Smith's ECG Blog - September 10, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
Technological Progress Is Really Off And Rolling At An Amazing Pace!
Last week I had the misfortune to have what I have been led
to believe was a small myocardial infarction, which I am happy to report I have
apparently survived.
In true doctor fashion I had been ignoring some minor chest
discomfort until last Sunday week when a doctor friend insisted I go an be
a ssessed at the local teaching hospital (RNSH) at which I had worked decades
ago. My, have things
Source: Australian Health Information Technology - September 6, 2023 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem ce...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Perspective on the Coming Regulatory Shift to Approval of Drugs to Treat Aging
At some point, regulatory bodies that oversee the development of new medicine will accept that therapies can target causative mechanisms of aging in order to slow or reverse the progression of aging, and that there are viable ways to assess new treatments that treat aging. There is growing pressure from the academic community and longevity-focused biotech industry for the ability to run clinical trials to treat aging, rather than to treat one specific age-related disease.
While inevitable, this change will take some years to come to pass, and likely require greater consensus in the research community on reasonable a...
Source: Fight Aging! - August 29, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants in...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Longevity-Associated Variant of BPIFB4 Reduces Heart Disease Severity
Few human longevity-associated gene variants are replicated in multiple patient populations. One of those is a variant of BPIFB4, that appears to improve immune function and lower inflammation by adjusting the behavior of macrophage cells of the innate immune system. Delivering the variant to mice using a gene therapy has similar effects. It may well operate via other mechanisms as well, however. Few proteins in a living cell turn out to have only one purpose.
In today's open access paper, researchers report that the BPIFB4 variant reduces the severity of coronary artery disease in humans and mice. Delivering the va...
Source: Fight Aging! - August 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
75 year old dialysis patient with nausea, vomiting and lightheadedness
Written by Jesse McLaren A 75 year-old patient with diabetes and end stage renal
disease was sent to the ED after dialysis for three days of nausea, vomiting,
loose stool, lightheadedness and fatigue. RR18 sat 99% HR 90 BP 90/60, afebrile. Below is the 15 lead ECG. What do you think? There ’s normal sinus rhythm, normal conduction, normal axis,
normal R wave progression and normal voltages. There’s subtle inferior ST
elevation with straightening of the ST segment, reciprocal ST depression and T
wave inversion in aVL, and ST depression in V2. This is diagnostic of
infero-posterior OMI, but it is falsely n...
Source: Dr. Smith's ECG Blog - August 19, 2023 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Associations Between the Lipidome and Epigenetic Aging
The body contains hundreds of different types of lipid molecules, participating in cellular metabolism in ways that are just as complex and relevant to health as the activities of other biomolecules. In the context of aging, this broad range of lipids are perhaps understudied in comparison to levels and roles of proteins and patterns of gene expression. The situation is much the same, however: researchers can readily and cost-effectively amass a vast amount of data, but the analysis of this data lags far behind the accumulation of ever more and ever larger omics databases. It is ever unclear as to whether any particular as...
Source: Fight Aging! - August 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Raised Remnant Cholesterol Level Correlates with Frailty
Remnant cholesterol refers to circulating cholesterol in the bloodstream that is not attached to LDL transport particles coming from the liver or HDL transport particles going to the liver. The remnant is attached to some mix of VLDL and IDL particles that serve much the same purpose as LDL particles, or incorporated into much larger chylomicron transporters that carry dietary lipids from the intestines throughout the body.
Researchers have noted that remnant cholesterol appears to contribute to cardiovascular risk, speeding the progression of atherosclerosis and increasing the risk of stroke and heart attack. It is...
Source: Fight Aging! - August 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
OMI Pocket Guide
📕OMI Pocket Guide TheOMI Pocket Guide (https://omiguide.org) is a user-friendly online resource designed to help healthcare professionals learn how to recognize subtle signs of acute coronary occlusion on the ECG which represent occlusion myocardial infarctions (OMI). Learning to recognize OMIs is an important clinical skill because it helps identify the subpopulation of " NSTEMIs " who are likely to be found with total thrombotic occlusion at the time of cardiac catherization.Although there are more criteria to consider when looking for OMIs compared to STEMIs, anyone can learn them, and this guid...
Source: Dr. Smith's ECG Blog - August 3, 2023 Category: Cardiology Authors: Mark Hellerman Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Blood Pressure Meds vs Blood Thinners: What ’ s The Difference?
Conclusion
In conclusion, while blood pressure medicines and blood thinners are both crucial to heart health, their roles and mechanisms of action are notably distinct. Blood pressure medication works primarily on the vascular system, aiding in reducing blood pressure by relaxing blood vessels or altering the heart’s function. On the other hand, blood thinners target the blood itself, working to prevent the formation of potentially dangerous blood clots.
Throughout this article, one thing becomes undeniably clear: the importance of regular consultations with your healthcare provider. When it comes to managing m...
Source: The EMT Spot - July 20, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A 40-something presented after attempted prehospital resuscitation with persistent Ventricular Fibrillation
A 40-something with persistent Ventricular Fibrillation presented after attempted prehospital resuscitationA 40-something with no previous cardiac history presented to the ED in persistent Ventricular Fibrillation after attempted prehospital resuscitation. He underwent further standard resuscitation EXCEPT that we applied the Inspiratory Threshold Device (ResQPod) AND applied Dual Sequential Defibrillation (this simply means we applied 2 sets of pads, had 2 defib machines, and defibrillated with both with only a fraction of one second separating each defibrillation.Two recent interventions have proven in randomized t...
Source: Dr. Smith's ECG Blog - July 14, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
