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Total 340 results found since Jan 2013.

“The Greatest Scientist of All Time” says Scientific American. Who is it?
BY MIKE MAGEE When it comes to our earthly survival as a human species, words are often under-powered and off-the-mark. Clearer concepts, definitions and terms are required for clarity. Here are five terms that are useful and worth remembering: Planetary Boundaries Earth Systems Human Perturbations Planetary Scale Destabilization Holocene Epoch vs. Anthropogenic Epoch  These terms all tie back to a single source – a child of World War II, only seven when his home in Amsterdam was overrun by Nazis. His father was a waiter, his mother a cook in a local hospital. He’d later recall with a sh...
Source: The Health Care Blog - September 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Chemistry Mike Magee Ozone Paul Crutzen Scientific American Source Type: blogs

Has Sensemaking Collapsed When It Comes To U.S. Healthcare?
By MIKE MAGEE This past week my wife and I were at a family event to celebrate my brother-in-law’s 70th birthday. Our extended family has more than a few doctors. A physician nephew who had read CODE BLUE and had a strong interest in health policy asked if I felt I (and others) were too hard on doctors. My response was yes, but that it was intentional and came with the territory. Combining scientific, sometimes life and death expertise, with high-touch compassion, understanding and partnership has always been a “big ask” but that was what we and others had signed up for as “health professionals.” But can a ...
Source: The Health Care Blog - September 5, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Deming Don Berwick ESCAPE FIRE Karl E. Weick Mike Magee Physicians Sensemaking Source Type: blogs

Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men. « Back to Top Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/ Neurogenesis is the process by which new neurons are created by neural stem ce...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Physical Fitness Correlates with Slower Epigenetic Aging in Newer DNA Methylation Clocks
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
Source: Fight Aging! - August 31, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Survivors of Nuclear Weapon Use in Early Life Exhibit Accelerated Immune Aging in Late Life
It probably strains the meaning of the term to call the aftermath of the use of nuclear weapons at the end of the Second World War a natural experiment, but nonetheless there has been considerable study of survivors from those events and their health relative to control populations in other parts of Japan. Irradiation is known to produce what is effectively accelerated aging in the context of cancer treatment, producing an increased burden of senescent cells that then ensure the later course of health for survivors is worse than would otherwise be the case, absent both cancer and treatment. In the case of exposure to radia...
Source: Fight Aging! - August 14, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Zilebesiran: A Promising Leap Forward In Hypertension Management
Conclusion As we draw the curtain on this insightful dive into Zilebesiran, a couple of takeaways stand out. Zilebesiran, the promising twice-yearly shot, is opening new frontiers in hypertension management. With its ability to suppress angiotensin production, it offers a fresh approach that could alleviate the burden of daily pill regimens. But the shot is still in its developmental phase, and further research is crucial to fully understand its capabilities and limitations. Still, it’s important to remember that medications are only a part of the solution. The enduring message from health professionals is ...
Source: The EMT Spot - July 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs

Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Study Uncovers: Brushing Teeth Twice Daily Reduces Heart Disease Risk
Conclusion The study came full circle, offering an emphatic conclusion. While a morning brush is a good start, brushing before bedtime takes the crown when it comes to preventing heart diseases. The act of brushing your teeth, so mundane yet so essential, emerges as a key soldier in the battle against heart disease. The findings beckon us to look at our toothbrushes differently – as tools of preventative care rather than just instruments of oral hygiene. The message is clear – taking care of our teeth could mean taking care of our hearts. After all, our health, as this study suggests, is a...
Source: The EMT Spot - July 4, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs

The Best ChatGPT Plugins: How To Add Browsing, Learning, Wolfram And More
ChatGPT plugins became available a few weeks ago and I have been testing them to see what they can do. They offer interesting new features from all walks of life, so let’s take a look at these new gadgets. What are ChatGPT plugins and how you can get them?  You can imagine these as apps on your phone: little extra programs that give ChatGPT extra skills.  How to enter the beta features?  You need to have GPT-4 access, which comes with the paid accounts. If you have GPT-4, click on your name on the bottom left, go to settings, click on beta features and allow them with the slider.  How t...
Source: The Medical Futurist - June 27, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF artificial intelligence ChatGPT plugins digital health Medicine AI in healthcare AI in medicine Source Type: blogs

Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT. Age-Related Dysfunction of Water Homeostasis https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/ Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechani...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Analysis Of Over 10,000 Healthcare AI Patents Highlights Future Trends: Our New Study
We are thrilled to announce the recent publication of our new study, Forecasting Artificial Intelligence Trends in Health Care: Systematic International Patent Analysis in the Journal of Medical Internet Research AI (JMIR AI). Our study takes an interesting deep dive into healthcare AI patents from the last decade, analysing over 10,000 of them from 2012 to 2022. Through this exploration, we shed light on the growth trends, the direction AI innovation is heading in different medical specialties, and the potential future implications of AI and Machine Learning (ML) in healthcare. Our journey into the world of healthcare ...
Source: The Medical Futurist - June 15, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI patents digital health patent analysis future Innovation machine learning AI in healthcare AI in medicine Source Type: blogs

Juicy Discovery: Can Japanese Plum Juice Beat Hypertension?
Conclusion: The Future Of Bainiku-Ekisu The next phase of Dr. Eguchi’s research intends to pinpoint the specific compounds in bainiku-ekisu responsible for its protective effects. He suggested that there might be two or three compounds acting in concert, resulting in additive or synergistic effects potentially lost in a pharmaceutical preparation. This research, sponsored by the National Institutes of Health and a research gift fund from Kobayashi Pharmaceutical Japan, might be an important step forward in managing hypertension and preventing cardiovascular diseases. Time will reveal whether the humble ...
Source: The EMT Spot - June 14, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs

Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How the Arts transform our Brains, Bodies, and Minds
One of my favorite sayings comes from David Thoreau: “My life has been the poem I would have writ / But I could not both live and utter it.” It speaks to the way that life and art are intertwined, and how we gain so much from living life with a sense of beauty and aesthetics in mind. There are many ways art infuses my own life—from singing and playing guitar to reading novels and attending plays, which all help to improve my mood and enhance my sense of wonder with the world. Probably, neuroaesthetics many of you feel the same way. Some of you may have felt you’ve even been saved by art. Now, a new book, Your Brai...
Source: SharpBrains - May 31, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning art neuroaesthetics Your Brain on Art Source Type: blogs