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Total 846 results found since Jan 2013.

New variant of COVID-19
A new variant is not a new thing, of course, but BA.2.86, known also as Pirola, seems to be causing some concern in the UK and elsewhere.  It seems a long time ago that I compiled page after page on this blog about COVID-19.  Those pages are still there, hopefully all labelled to make it clear they are no longer being updated.I wondered if a few resources on this new variant would be useful.  In case I am right, here are some.  I don ' t know how long this one will be useful for, but will try to keep it updated.  A PubMed search for BA.2.86 finds a few.  Adding Pi...
Source: Browsing - September 9, 2023 Category: Databases & Libraries Tags: coronavirus COVID-19 Source Type: blogs

Air, Air, Everywhere, and Not a Breath Safe to Take
BY KIM BELLARD If you live, as I do, anywhere in the Eastern half of the country, for the past week you’ve probably been thinking about something you’re not used to: wildfires.  Sure, we’ve all been aware of how wildfires routinely plague the West Coast, particularly Oregon and Washington, but it’s novel for the East. So when the smoke from Canadian wildfires deluged cities through the East and Midwest, it came as kind of a shock. For a day last week, New York City supposedly had the worst air quality in the world.  The next day Philadelphia had that dubious distinction.  The air quality index ...
Source: The Health Care Blog - June 14, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Climate Change East Coast Kim Bellard West Coast Wildfires Source Type: blogs

America ’ s ailing health care system: How it ’ s failing patients and doctors
As painfully revealed by the coronavirus pandemic, the American health care system is ailing, plagued by the inefficiencies and greed of big business and for-profit medicine.   It is not unlike the virus, attacking vital organs one by one until the whole is weakened. In more grave cases, the severely ill can’t survive. In much the Read more… America’s ailing health care system: How it’s failing patients and doctors originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 27, 2023 Category: General Medicine Authors: Tags: Policy Public Health & Policy Source Type: blogs

Medicine and history: a seemingly unlikely but necessary duo in understanding COVID-19 disparities  
“Hispanic community makes up more than half of coronavirus cases in Southwest Michigan county” was the headline in the newspaper that caught my eye in August 2020 – that infamous year that the nation went into lockdown to prevent the spread of what was still a new and emerging virus. It shocked me to realize Read more… Medicine and history: a seemingly unlikely but necessary duo in understanding COVID-19 disparities  originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 21, 2023 Category: General Medicine Authors: Tags: Policy COVID Public Health & Policy Source Type: blogs

A big data COVID train wreck
BY ANISH KOKA If there was any doubt the academic research enterprise is completely broken, we have an absolute train wreck of a study in one of the many specialty journals of the Journal of the American Medical Association — JAMA Health. I had no idea the journal even existed until today, but I now know to approach the words printed in this journal to the words printed in supermarket tabloids. You should too! The paper that was brought to my attention is one that purports to examine the deleterious health effects of Long COVID. A sizable group of intellectuals who are still socially distancing and wearing n95s ...
Source: The Health Care Blog - March 13, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Anish Koka Covid research COVID-19 Long Covid Source Type: blogs

Breaking free from corporate medicine: one doctor ’ s quest for ethical care
An excerpt from If I Betray These Words: Moral Injury in Medicine and Why It’s So Hard for Clinicians to Put Patients First. In late March 2021, during a lull between the third and fourth waves of the coronavirus pandemic, I drove to the small town three hours west of the Mississippi River where a Read more… Breaking free from corporate medicine: one doctor’s quest for ethical care originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - February 25, 2023 Category: General Medicine Authors: Tags: Physician Primary Care Psychiatry Source Type: blogs

TWiV 984: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during […]
Source: virology blog - February 18, 2023 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation influenza Long Covid monkeypox monoclonal antibody Omicron pandemic poliovirus SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs

Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes. Communication Between Blood and Brain in Aging and Rejuvenation https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/ As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inter...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Towards Microneedle Delivery of LNP-mRNA Gene Therapies for Skin Aging
The skin is arguably one of the easiest of the large organs in the body to target for delivery of gene therapies, via established microneedle approaches. Nonetheless, much of the initial thrust of gene therapy clinical development focused instead on the liver, one of the other more tractable targets. Most material injected into the bloodstream ends up in the liver, and a single injection is logistically easier than coverage of large amounts of skin via microneedle patches, among other reasons. Given the advent of messenger RNA (mRNA) encapsulated in lipid nanoparticles (either artificial or repurposed extracellular ...
Source: Fight Aging! - January 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Foobaw and more
Let me start with Damar Hamlin. His physicians haven ' t said anything publicly about what happened to him, but there are basically two possibilities. First, it is obviously uncommon but not unheard of for apparently healthy athletes to suffer cardiac arrest during exertion. This happened to Boston Celtics star Reggie Lewis. I happened to be in Boston Garden watching the first round playoff game against the Charlotte Hornets on April 29, 1993 when Lewis collapsed. All of the spectators were baffled about what  had happened.  Doctors at New England Baptist Hospital later diagnosed him with a heart abnormality...
Source: Stayin' Alive - January 6, 2023 Category: American Health Source Type: blogs

Fight Aging! Newsletter, December 12th 2022
In conclusion, selective removal of senescent dermal fibroblasts can improve the skin aging phenotype, indicating that BPTES may be an effective novel therapeutic agent for skin aging. Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function https://www.fightaging.org/archives/2022/12/non-dividing-neurons-do-in-fact-become-senescent-impairing-brain-function/ Cellular senescence is generally thought of as a characteristic of replicating cells; it is an end state reached when telomeres, reduced in length with each cell division, become too short. This is followed by programmed cell death ...
Source: Fight Aging! - December 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Long Discussion of the Role of Senescent Cells in Idiopathic Pulmonary Fibrosis
Senescent cells are constantly created and destroyed throughout life, largely as a result of the replicative senescence that marks the end of life for a somatic cell, the Hayflick limit on cell division. With age, the pace of creation and destruction is disrupted, perhaps largely because the immune system ages to the point at which it falters in all of its tasks, clearance of senescent cells included. Senescent cells accumulate, and while never making up more than a small fraction of all somatic cells in any given tissue, the pro-growth, pro-inflammatory signaling generated by senescent cells is highly disruptive to organ ...
Source: Fight Aging! - December 9, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The Top 20 Digital Health Trends For The Near Future: Here Is The 2022-23 Ebook
What is going to happen in the future of medicine? What will healthcare look like? And how will our roles change as healthcare goes increasingly digital? Which digital health trends are worthy of attention and which will prove to be just hype? These are some of the questions most often asked by healthcare professionals and industry experts. In the 2022-23 update of The Top 20 Digital Health Trends For The Near Future we highlighted 20 developments likely to happen in the upcoming 2-5 years. They are based on our analyses of trends and relevant technologies that we have been constantly monitoring. We would encourage ...
Source: The Medical Futurist - December 1, 2022 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Forecast Digital Health Research alivecor ecg portable diagnostics telemedicine chatbots cdc around the pill Daichii-Sankyo coronavirus self checker Source Type: blogs

Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs