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Many Researchers and Companies Will Aim to Produce Small Molecule Reprogramming Therapies
The typical path for any program in biomedical research and development is to first demonstrate interesting results in animal studies using forms of genetic engineering or gene therapy, and then find small molecules that adjust the same mechanism. Small molecules are never as good as genetic manipulations, the size of the effect is always smaller, usually much smaller, and there are inevitably side-effects. Small molecule development is much easier to conduct, however, more familiar to investors and regulators and program managers, a well-trodden path. Thus while the future of medicine is gene therapy, in search of large e...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The Lack of Consensus on Approaches to Aging as a Flaw to be Fixed
It can be argued that the largest challenge facing the development of means to treat aging as a medical condition is that there is, as of yet, no useful consensus position on how to measure aging, how to define aging, or which of the countless measurable aspects of biochemistry that change with age are the most appropriate targets for therapy. This means that any given research group or biotech startup has a lot of leeway to argue that their approach is the right one - and it might take twenty years to establish the effects of their therapies on long-term health and life span, even given a successful development program. T...
Source: Fight Aging! - September 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Healthcare IT Regulations – What Needs to Be Added and What Needs to Be Removed
There are a lot of rules and regulations in place in the world of healthcare. These are put into place in order to protect patients and organizations. However, the world of healthcare is constantly changing and evolving as we come up with new ideas and solutions. Have the regulations done the same though? Or are there areas that are missing regulations? Or are there areas in healthcare where past regulations are now too restrictive and are holding us back? In search of answers to these questions, we reached out to our incredibly beautiful Healthcare IT Today Community to see what areas they would add, remove, or update re...
Source: EMR and HIPAA - September 19, 2023 Category: Information Technology Authors: Grayson Miller Tags: Administration Ambulatory C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System LTPAC Regulations 1upHealth 4medica Amanda Heidemann Andrea Mazzoccoli Andrew Norden MD Bill Charnetski Cheryl Cheng Commur Source Type: blogs

Ensuring Fairness in Medical Education Assessment
This study takes a first step in centering the margins as we as medical educators grow our understanding of the dynamics of promoting fairness in assessment. Future studies should explore feedback with intentional inclusion and involvement of diverse students, teachers, and researchers at every stage of the research process from conceptualization through dissemination and application of the new learning. We thank our participants for their time and candor discussing this sensitive topic and the Group on Educational Affairs for funding our work. Thank you for your time and attention and the focus that you’ll put on th...
Source: Academic Medicine Blog - September 18, 2023 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast assessment equity Macy Foundation medical education Source Type: blogs

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

DNA Damage and Consequent Inflammation in Heart Failure
One of the ways in which cell damage characteristic of aging can provoke inflammation is via the mislocalization of DNA. Either nuclear DNA or mitochondrial DNA can find its way to the cytosol, where it can trigger responses evolved to detect bacterial or viral infection, or severe cell damage. This creates a cascade of downstream signaling leading to an inflammatory response. In youth these events occur comparatively rarely, and in circumstances wherein immune response and potentially even cell death are beneficial. With age, however, there is a continued mild but growing level of dysfunction and consequent sustained infl...
Source: Fight Aging! - September 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The Cost of Cardiovascular Disease
Age-related disease places a huge financial burden on individuals and their caregivers; even the need for caregivers arises only because aging produces disability. Even only considering cardiovascular disease, the largest contribution to human mortality, the costs are enormous. This is a point often made by advocates arguing for greater institutional funding of ways to treat aging. Present levels of funding for research and development of means to reduce age-related disease are very low in comparison to the massive ongoing costs that result from age-related disease. It makes little sense for this to be the case in an age o...
Source: Fight Aging! - September 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Intermittent Fasting Reduces Pathology in a Mouse Model of Alzheimer ' s Disease
The sizable body of work produced on calorie restriction and fasting over the last twenty years is supportive of the hypothesis that time spent hungry is an important factor determining the scale of benefits to health and longevity. The cellular response to a transient lack of nutrients involves improved cell maintenance, such as upregulation of autophagy to clear out damaged and worn molecular machinery. Looking at a level of organization above the cell, a transient state of hunger likely produces many other benefits to the way in which complex tissues and relationships between tissues function in the body. It dampens inf...
Source: Fight Aging! - August 30, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Let ’ s Start Over
BY KIM BELLARD When I first read the reports about some Silicon Valley billionaires wanting to start a new city, I figured, oh, it’s just a bunch of rich white guys wanting to take their toys and go to a new, better home. After all, they’ve seen what’s been happening to downtown San Francisco (or Portland, or Chicago – pick your preferred city).   Cities these days may be an what one expert calls an “urban doom loop” – struggling to recover after having been hollowed out by the pandemic. These so-called elites probably figured it’s easier to build something new rather than to try to fix what already ...
Source: The Health Care Blog - August 29, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: The Business of Health Care Flanner Associates Kim Bellard Silicon Valley Urban Doom Loop Zoning Source Type: blogs

Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Weekly Roundup – August 19, 2023
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week. Helping Children With Gamified Interactive Physiotherapy. Psychiatrist Dr. Geoff Frost struggled to encourage pediatric patients with spinal muscular atrophy to do their necessary exercises. As he explained to Colin Hung, that’s why Raft Digital Therapeutics created a game called Cloud Bazaar to captures a child’s movement as a way to advance...
Source: EMR and HIPAA - August 19, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs

Associations Between the Lipidome and Epigenetic Aging
The body contains hundreds of different types of lipid molecules, participating in cellular metabolism in ways that are just as complex and relevant to health as the activities of other biomolecules. In the context of aging, this broad range of lipids are perhaps understudied in comparison to levels and roles of proteins and patterns of gene expression. The situation is much the same, however: researchers can readily and cost-effectively amass a vast amount of data, but the analysis of this data lags far behind the accumulation of ever more and ever larger omics databases. It is ever unclear as to whether any particular as...
Source: Fight Aging! - August 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Weekly Roundup – August 12, 2023
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week. Achieving Interoperability One Practical Byte at a Time. Upstate New York’s Rochester Regional Health began its interoperability journey with lab data, Colin Hung learned, as there was a clear need to bring in lab test results from many external sources to help care teams make better clinical decisions and improve outcomes. Read more… Surescr...
Source: EMR and HIPAA - August 12, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs

Developing Therapies to Treat Aging is No Less Challenging than Other Areas of Biotech
The biotech industry experiences a high failure rate, if we wish to define failure as failing to achieve the original goals of the research program that gave rise to a company. The article noted here opens with many examples to give a sense of the prevalence of companies in the early aging-focused space that altered their course to give a return to their investors by other means, after it proved too challenging to achieve the original vision. This is par for the course: the development of novel medical biotechnology is both very difficult and highly regulated. The grail of producing new medicine that is accepted by the reg...
Source: Fight Aging! - August 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs