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Total 410 results found since Jan 2013.
A 50-something with Regular Wide Complex Tachycardia: What to do if electrical cardioversion does not work?
Case submitted by anonymous. Written by Smith. Ken ' s piece at the bottom is excellent.A 50-something presented with sudden onset palpitations 8 hrs prior while sitting at desk at work. He had concurrent sharp substernal chest pain that resolved, but palpitations continued.Over past 3 months, he has had similar intermittent episodes of sharp chest pain while running, but none at rest. Past medical history includes coronary stenting 17 years prior. A brief chart review revealed his most recent echo in 2018, with LV EF 67%, “very small” inferior wall motion abnormality.Initial ED ECG:What do you think?This wa...
Source: Dr. Smith's ECG Blog - September 20, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
A 50-something with Regular Wide Complex Tachycardiaa: What to do if electrical cardioversion does not work?
Case submitted by anonymous. Written by Smith. Ken ' s piece at the bottom is excellent.A 50-something presented with sudden onset palpitations 8 hrs prior while sitting at desk at work. He had concurrent sharp substernal chest pain that resolved, but palpitations continued.Over past 3 months, he has had similar intermittent episodes of sharp chest pain while running, but none at rest. Past medical history includes coronary stenting 17 years prior. A brief chart review revealed his most recent echo in 2018, with LV EF 67%, “very small” inferior wall motion abnormality.Initial ED ECG:What do you think?This wa...
Source: Dr. Smith's ECG Blog - September 20, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Cells Release Insulin in Response to Music
Researchers at ETH Zurich have developed an insulin delivery system that relies on music as a trigger. The unusual technology is based on calcium ion channels that typically reside in the cell membrane. Such channels are sensitive to mechanical defor...
Source: Medgadget - September 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine diabetes ETH Zurich Source Type: blogs
A 40 year old with nonspecific symptoms including dizziness
.What do you notice about the ECG?There is a very short QT interval. This is often found in hypercalcemia. See Ken Grauer ' s comments below for detail.Thus, the patient ' s chemistry was done and revealed ionized hypercalcemia of 6.3 mg/dL (normal 4.4 - 5.2)Followup: he was found to have hyperparathyroidism===================================MY Comment, by KEN GRAUER, MD (9/12/2023):===================================Today ' s ECG is remarkable for an uncommon but important finding that we periodically review, because it otherwise is all-too-easy to overlook. For example — Did YO...
Source: Dr. Smith's ECG Blog - September 12, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
“The Greatest Scientist of All Time” says Scientific American. Who is it?
BY MIKE MAGEE
When it comes to our earthly survival as a human species, words are often under-powered and off-the-mark. Clearer concepts, definitions and terms are required for clarity. Here are five terms that are useful and worth remembering:
Planetary Boundaries
Earth Systems
Human Perturbations
Planetary Scale Destabilization
Holocene Epoch vs. Anthropogenic Epoch
These terms all tie back to a single source – a child of World War II, only seven when his home in Amsterdam was overrun by Nazis. His father was a waiter, his mother a cook in a local hospital. He’d later recall with a sh...
Source: The Health Care Blog - September 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Chemistry Mike Magee Ozone Paul Crutzen Scientific American Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants in...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Distinct Signatures for Human Microglia in Alzheimer ' s Disease
This study identified 10 distinct microglia clusters from aged human brain. These included previously described homeostatic, senescent, and inflammatory microglia transcriptional phenotypes as well as additional clusters of transcriptional specification, which may give insight into AD pathogenesis, providing a platform for hypothesis generation. We describe the diversity of microglia clusters with endolysosomal gene signatures, one of which is enriched with nucleic acid recognition and interferon regulation genes. Inferred gene networks predict that individual clusters are driven by distinct transcription factors, lending ...
Source: Fight Aging! - August 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
When Mark Cuban Cost Plus Drug Company Says Your Prescription is " Out of stock "
My followers may recall that about a year ago (on August 22, 2023), I blogged about (see https://blog.sstrumello.com/2022/08/generic-crestor-pricing-insanity.html for the post) that I had made a conscious decision to simply disintermediate my own insurance pharmacy benefit to buy an inexpensive generic statin drug because my own pharmacy benefit manager was screwing me. Currently, I ' m covered by Aetna which is now owned by CVS Health, which also owns the PBM known as Caremark. Caremark was robbing me on the statin. It was overcharging me. They were trying to charge me $33.85 for a 90-day supply of a cheap...
Source: Scott's Web Log - August 1, 2023 Category: Endocrinology Tags: 2023 cash pharmacy cash-only pharmacy Crestor Mark Cuban Cost Plus Drug Company rosuvastatin calcium Source Type: blogs
Central Agonists For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In summary, central agonists, a notable class of hypertension medications, offer an alternative modality when other first-line antihypertensive treatments fail to show desired results or cause intolerable side effects.
They operate via a unique neurocentric mechanism that primarily functions centrally in the brain, impacting blood pressure regulation by decreasing systemic arterial pressure and heart rate.
Despite their potential side effects and potential for interactions with other drugs, their therapeutic utility in the context of hypertension management remains undiminished.
Moreover, certain cen...
Source: The EMT Spot - July 27, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Handling Heat On Blood Pressure Medication: Your Summer Health Guide
Conclusion
Summing it up, individuals taking blood pressure medication must be cautious during the hot weather season. Heat exposure can significantly impact blood pressure and may amplify the effects of medication, leading to potentially harmful health conditions.
These risks, however, can be managed with the right precautions such as staying hydrated, dressing appropriately, and planning outdoor activities during cooler times of the day.
Importantly, each person’s response to heat and medication varies. Hence, a one-size-fits-all approach isn’t ideal. Your healthcare provider is an invaluable resourc...
Source: The EMT Spot - July 26, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Blood Pressure Meds vs Blood Thinners: What ’ s The Difference?
Conclusion
In conclusion, while blood pressure medicines and blood thinners are both crucial to heart health, their roles and mechanisms of action are notably distinct. Blood pressure medication works primarily on the vascular system, aiding in reducing blood pressure by relaxing blood vessels or altering the heart’s function. On the other hand, blood thinners target the blood itself, working to prevent the formation of potentially dangerous blood clots.
Throughout this article, one thing becomes undeniably clear: the importance of regular consultations with your healthcare provider. When it comes to managing m...
Source: The EMT Spot - July 20, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Pulmonary Arterial Hypertension: Unraveling Its Impact On Heart And Lungs
Conclusion
Navigating the complexities of Pulmonary Arterial Hypertension (PAH) might seem daunting. However, with the right knowledge and proactive approach, it’s possible to manage the condition and maintain a good quality of life.
PAH, a unique type of high blood pressure affecting the arteries in the lungs, can put extra strain on the heart. Over time, this can lead to heart failure. The condition’s root cause may vary, from genetic factors to other health issues like heart defects, liver disease, or autoimmune diseases. Remember, sometimes the cause remains unknown, resulting in idiopathic pulmonary ...
Source: The EMT Spot - July 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Late Life Rapamycin Treatment Reverses Diastolic Dysfunction in Mice
Inhibitors of mTOR such as rapamycin are increasingly well studied. This class of drug stimulates cellular stress responses, principally autophagy, and thus produces outcomes that are broadly similar to the long-term improvement of health resulting from calorie restriction, exercise, or other demonstrated means of upregulating autophagy. This results in benefits to health, such as those noted in today's open access paper.
It is one thing to demonstrate that a drug improves measures of autophagy known to decline with age, and note that many of the interventions shown to modestly slow aging in laboratory species are c...
Source: Fight Aging! - July 14, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
