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Lithium Versus Other Mood-Stabilizing Medications in a Longitudinal Study of Youth Diagnosed With Bipolar
Lithium is the mainstay for bipolar disorder (BD) treatment in adults, but evidence in youths is limited. We used data from the Course and Outcome of Bipolar Youth (COBY) study to assess whether lithium versus other mood-stabilizing medication (OMS) was associated with improved outcomes, including mood symptoms and suicidality.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - July 28, 2019 Category: Psychiatry Authors: Danella M. Hafeman, Brian Rooks, John Merranko, Fangzi Liao, Mary Kay Gill, Tina R. Goldstein, Rasim Diler, Neal Ryan, Benjamin I. Goldstein, David A. Axelson, Michael Strober, Martin Keller, Jeffrey Hunt, Heather Hower, Lauren M. Weinstock, Shirley Yen, Tags: New research Source Type: research

MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans
MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in <i>C. elegans</i>, Published online: 06 February 2019; doi:10.1038/s41418-019-0291-zMINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans
Source: Cell Death and Differentiation - February 6, 2019 Category: Cytology Authors: Ataman Sendoel Deni Subasic Luca Ducoli Martin Keller Erich Michel Ines Kohler Kapil Dev Singh Xue Zheng Anneke Br ümmer Jochen Imig Shivendra Kishore Yibo Wu Alexander Kanitz Andres Kaech Nitish Mittal Ana M. Matia-Gonz ález Andr é P. Gerber Mihaela Z Source Type: research

Task-dependent activation of distinct fast and slow(er) motor pathways during motor imagery
ConclusionsThis study provides evidence that the excitability of fast and slow(er) motor pathways during motor imagery resembles the activation pattern observed during real contractions. The findings indicate that motor imagery results in task- and pathway-specific subliminal activation of distinct subsets of neurons in the primary motor cortex.
Source: Brain Stimulation - July 10, 2018 Category: Neurology Source Type: research

CO2 activation by methane in a dual-bed configuration via methane cracking and iron oxide lattice oxygen transport – Concept and materials development
Publication date: 1 October 2018 Source:Chemical Engineering Journal, Volume 349 Author(s): Martin Keller, Yoshio Matsuzaki, Junichiro Otomo In this work we describe a novel process configuration for CO2 activation into CO via methane cracking. This is achieved in a two-reactor configuration by circulating supported iron oxide/iron particles with deposited carbon between the two reactors. Thermodynamic equilibrium calculations indicate that reactor configurations with counter-current gas-solids flow enable a high CO yield and concentration in the product gas. With both reactors in counter-current flow at 850 °C the pot...
Source: Chemical Engineering Journal - May 19, 2018 Category: Chemistry Source Type: research

Task-dependent activation of distinct fast and slow(er) motor pathways during motor imagery
Conclusions This study provides evidence that the excitability of fast and slow(er) motor pathways during motor imagery resembles the activation pattern observed during real contractions. The findings indicate that motor imagery results in task- and pathway-specific subliminal activation of distinct subsets of neurons in the primary motor cortex.
Source: Brain Stimulation - February 23, 2018 Category: Neurology Source Type: research

Surround Inhibition in the Primary Motor Cortex is Task-specifically Modulated in Non-professional Musicians but not in Healthy Controls During Real Piano Playing
Publication date: 1 March 2018 Source:Neuroscience, Volume 373 Author(s): Gonzalo Márquez, Martin Keller, Jesper Lundbye-Jensen, Wolfgang Taube Research has indicated that at the onset of a finger movement, unwanted contractions of adjacent muscles are prevented by inhibiting the cortical areas representing these muscles. This so-called surround inhibition (SI) seems relevant for the performance of selective finger movements but may not be necessary for tasks involving functional coupling between different finger muscles. Therefore, the present study compared SI between isolated finger movement and complex selective fing...
Source: Neuroscience - February 6, 2018 Category: Neuroscience Source Type: research

Sexual Risk Behavior Among Youth With Bipolar Disorder: Identifying Demographic and Clinical Risk Factors
This study aims to document rates of sexual activity among youth with bipolar spectrum disorder (BD), and to examine demographic and clinical factors associated with first sexual activity and sexual risk behavior over follow-up.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - November 25, 2017 Category: Psychiatry Authors: Megan Krantz, Tina Goldstein, Brian Rooks, John Merranko, Fangzi Liao, Mary Kay Gill, Rasim Diler, Danella Hafeman, Neal Ryan, Benjamin Goldstein, Shirley Yen, Heather Hower, Jeffrey Hunt, Martin Keller, Michael Strober, David Axelson, Boris Birmaher Tags: New Research Source Type: research

Preparatory cortical and spinal settings to counteract anticipated and non-anticipated perturbations
Publication date: 4 December 2017 Source:Neuroscience, Volume 365 Author(s): Michael Wälchli, Craig D. Tokuno, Jan Ruffieux, Martin Keller, Wolfgang Taube Little is known about how the central nervous system prepares postural responses differently in anticipated compared to non-anticipated perturbations. To investigate this, participants were exposed to translational and rotational perturbations presented in a blocked (anticipated) and a random (non-anticipated) design. The preparatory setting (‘central set’) was measured by H-reflexes, motor-evoked potentials (MEPs), and short-interval intracortical inhibition (SICI...
Source: Neuroscience - October 11, 2017 Category: Neuroscience Source Type: research

Behavioral and neural adaptations in response to five weeks of balance training in older adults: a randomized controlled trial
While the positive effect of balance training on age-related impairments in postural stability is well-documented, the neural correlates of such training adaptations in older adults remain poorly understood. T...
Source: Journal of Negative Results in BioMedicine - June 13, 2017 Category: Research Authors: Jan Ruffieux, Audrey Mouthon, Martin Keller, Michael W älchli and Wolfgang Taube Source Type: research

Adopting an external focus of attention alters intracortical inhibition within the primary motor cortex
ConclusionThe level of intracortical inhibition was previously shown to influence motor performance. Our data shed new light on the ability to instantly modulate the activity of inhibitory circuits within M1 by changing the type of attentional focus. The increased inhibition with EF might contribute to the better movement efficiency, which is generally associated with focusing externally.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - September 20, 2016 Category: Physiology Authors: Yves ‐Alain Kuhn, Martin Keller, Jan Ruffieux, Wolfgang Taube Tags: Regular Paper Source Type: research

Interhemispheric sensorimotor integration; an upper limb phenomenon?
Publication date: 1 October 2016 Source:Neuroscience, Volume 333 Author(s): Kathy L. Ruddy, Ellen Jaspers, Martin Keller, Nicole Wenderoth Somatosensory information from the limbs reaches the contralateral Primary Sensory Cortex (S1) with a delay of 23ms for finger, and 40ms for leg (somatosensory N20/N40). Upon arrival of this input in the cortex, motor evoked potentials (MEPs) elicited by Transcranial Magnetic Stimulation (TMS) are momentarily inhibited. This phenomenon is called ‘short latency afferent inhibition (SAI)’ and can be used as a tool for investigating sensorimotor interactions in the brain. We used...
Source: Neuroscience - July 26, 2016 Category: Neuroscience Source Type: research

The proteasome immunosubunits, PA28 and ER‐aminopeptidase 1 protect melanoma cells from efficient MART‐126‐35 specific T‐cell recognition
This article is protected by copyright. All rights reserved
Source: European Journal of Immunology - September 24, 2015 Category: Allergy & Immunology Authors: Martin Keller, Frédéric Ebstein, Elke Bürger, Kathrin Textoris‐Taube, Xenia Gorny, Sabrina Urban, Fang Zhao, Tanja Dannenberg, Antje Sucker, Christin Keller, Loredana Saveanu, Elke Krüger, Hermann‐J. Rothkötter, Burkhardt Dahlmann, Petra Henklein Tags: Regular Article Source Type: research

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