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Total 50 results found since Jan 2013.

Muscle velocity recovery cycles in myopathy
CONCLUSIONS: The MVRC and RAMP parameters can discriminate between healthy controls and myopathy patients, more significantly for non-inflammatory myopathy. MVRC differences with normal MRRP in myopathy differs from other conditions with membrane depolarisation.SIGNIFICANCE: MVCR and RAMP may have a potential in understanding disease pathophysiology in myopathies. The pathogenesis in non-inflammatory myopathy does not seem to be caused by a depolarisation of the resting membrane potential but rather by the change in sodium channels of the muscle membrane.PMID:37148747 | DOI:10.1016/j.clinph.2023.04.001
Source: Clinical Neurophysiology - May 6, 2023 Category: Neurology Authors: M Meldgaard R S Kristensen W J Z'Graggen S V Tan K S øndergaard E Qerama H Andersen A Fuglsang-Frederiksen H Tankisi Source Type: research

Comment on & quot;Drug –Drug Interaction of the Sodium Glucose Co-Transporter 2 Inhibitors with Statins and Myopathy: A Disproportionality Analysis Using Adverse Events Reporting Data & quot;
Source: Drug Safety - April 15, 2023 Category: Drugs & Pharmacology Source Type: research

Author ’s Reply to Kuss and Rathmann’s Comment on: “Drug-Drug Interaction of the Sodium Glucose Co-transporter 2 Inhibitors with Statins and Myopathy: A Disproportionality Analysis Using Adverse Events Reporting Data”
Source: Drug Safety - April 15, 2023 Category: Drugs & Pharmacology Source Type: research

Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities
Biomed Pharmacother. 2022 Nov;155:113833. doi: 10.1016/j.biopha.2022.113833. Epub 2022 Oct 7.ABSTRACTPatients with heart failure (HF) usually present with skeletal muscle diseases of varying severity, ranging from early fatigue on exercise to sarcopenia, sarcopenic obesity or cachexia, and frailty, which are significant predictors of HF prognosis. Abnormal mitochondrial metabolism has been identified as one of the earliest signs of skeletal muscle injury in HF and is associated with pathological alterations in muscle, manifested as muscle wasting, myocyte atrophy and apoptosis, fiber type shift, impaired contractile coupli...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Jiayu Lv Yumeng Li Shuqing Shi Xia Xu Huaqin Wu Bingxuan Zhang Qingqiao Song Source Type: research

Genes, Vol. 13, Pages 1726: Gene Panel Sequencing Identifies a Novel RYR1 p.Ser2300Pro Variant as Candidate for Malignant Hyperthermia with Multi-Minicore Myopathy
We report a Korean having MH with multi-minicore myopathy functionally supported by RYR1-mediated intracellular Ca2+ release testing in B lymphocytes. A 14-year-old boy was admitted for the evaluation of progressive torticollis accompanied by cervicothoracic scoliosis. During the preoperative drape of the patient for the release of the sternocleidomastoid muscle under general anesthesia, his wrist and ankle were observed to have severe flexion contracture. The body temperature was 37.1 &deg;C. To treat MH, the patient was administered a bolus of dantrolene intravenously (1.5 mg/kg) and sodium bicarbonate. After a f...
Source: Genes - September 26, 2022 Category: Genetics & Stem Cells Authors: Young Jae Moon Joonhong Park Jung Ryul Kim Seung Yeob Lee Jaehyeon Lee Yong Gon Cho Dal Sik Kim Tags: Communication Source Type: research

Authors ’ Reply to Noguchi’s comment on: “Drug-Drug Interaction of the Sodium Glucose Co-transporter 2 Inhibitors with Statins and Myopathy: A Disproportionality Analysis Using Adverse Events Reporting Data.”
Source: Drug Safety - June 17, 2022 Category: Drugs & Pharmacology Source Type: research

Comment on: & quot;Drug –Drug Interaction of the Sodium Glucose Co-transporter 2 Inhibitors with Statins and Myopathy: A Disproportionality Analysis Using Adverse Events Reporting Data & quot;
Source: Drug Safety - June 17, 2022 Category: Drugs & Pharmacology Source Type: research

A case of anti-HMGCR myopathy triggered by sodium/glucose co-transporter 2 (SGLT2) inhibitors
We report the case of a 76-year-old woman who developed muscle weakness, fatigue, and increased CK, following treatment with dapagliflozin, a sodium/glucose co-transporter 2 (SGLT2) inhibitor, and metformin. Neurophysiology, muscle biopsy, and antibody dosage confirmed the diagn osis of IMNM. The temporal correlation between the onset of clinical manifestations and the increase in the dosage of antidiabetic drugs, the improvement of symptoms with the dechallenge of dapagliflozin, and the exclusion of other possible causes triggering myopathy suggests that this may be the fi rst case of dapagliflozin-induced myopathy, diffe...
Source: Neurological Sciences - April 7, 2022 Category: Neurology Source Type: research

Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease
Am J Physiol Heart Circ Physiol. 2022 Mar 25. doi: 10.1152/ajpheart.00690.2021. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and muscle function in the lower limbs. A skeletal muscle myopathy characterized by mitochondrial dysfunction and oxidative damage is present in PAD; however, the underlying mechanisms are not well-established. We investigated the impact of chronic ischemia on skeletal muscle microcirculatory function and its association with leg skeletal muscle mitochondrial function and oxygen delivery and utilization capacity in PAD. Gastrocnem...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 25, 2022 Category: Physiology Authors: Song-Young Park Elizabeth J Pekas Cody P Anderson Tyler N Kambis Paras K Mishra Molly N Schieber TeSean K Wooden Jonathan R Thompson Kyung Soo Kim Iraklis I Pipinos Source Type: research

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