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Total 461 results found since Jan 2013.
Chapter 3: Evidence for the Use of Early Rhythm Control to Prevent Atrial Fibrillation Progression
This chapter reviews atrial fibrillation (AF) progression and its associated mechanisms, including comorbidities and AF as contributors to atrial myopathy, and atrial myopathy as a contributing factor to AF progression. In addition, the chapter discusses the concept of comorbidities and atrial myopathy as synergistic contributors to adverse outcomes, the notion of “AF begets AF,” and the consequences of AF burden if left untreated. Clinical trials evaluating outcomes with antiarrhythmic drugs (AADs) compared with placebo have demonstrated efficacy, but also reveal a possible proarrhythmic and mortality risk if AAD sele...
Source: The American Journal of Cardiology - September 21, 2023 Category: Cardiology Authors: Thomas F. Deering, James A. Reiffel, Allen J. Solomon, Kamala P. Tamirisa Tags: Video article Source Type: research
Reversible cardiac function and left ventricular hypertrophy in a Chinese man with mitochondrial myopathy: a case report
Mitochondrial myopathies (MMs) are a group of multi-system diseases caused by abnormalities in mitochondrial DNA (mtDNA) or mutations of nuclear DNA (nDNA). The diagnosis of mitochondrial myopathy (MM) is reli...
Source: BMC Cardiovascular Disorders - September 15, 2023 Category: Cardiology Authors: Guiping Wu, Yijun Han, Lifeng Zhao, Hong Zhang, Xiuzhao Fan, Weiqin Li, Xiaowen Che and Yun Zhou Tags: Research Source Type: research
Transcriptomic Profiling Identifies Ferroptosis-Related Gene Signatures in Ischemic Muscle Satellite Cells Affected by Peripheral Artery Disease
CONCLUSIONS: This is the first report documenting that genes known to be involved in ferroptosis are differentially expressed in human skeletal muscle affected by PAD. Targeting ferroptosis may be a novel therapeutic strategy to reduce PAD myopathy.PMID:37675635 | DOI:10.1161/ATVBAHA.123.319518
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Lillian Tran Bowen Xie Edwyn Assaf Ricardo Ferrari Iraklis I Pipinos George P Casale Roberto Ivan Mota Alvidrez Simon Watkins Ulka Sachdev Source Type: research
Decrement Evoked Potential (DEEP) Mapping of the Atria: Unmasking Atrial Fibrillation Substrate
Atrial myopathy may underlie the progression of atrial fibrillation (AF) from a treatable disease to an irreversible condition with poor ablation outcomes. Electrophysiological methods to unmask areas prone to re-entry initiation could be key to defining latent atrial myopathy.
Source: Heart, Lung and Circulation - August 25, 2023 Category: Cardiology Authors: Oscar Salvador Monta ñés, John L. Fitzgerald, Nicholas Jackson, Shouvik Haldar, Haseeb Valli, Josh Cotton, Gwilym M. Morris, Sigfus Gizurarson, José Angel Cabrera, Kumaraswamy Nanthakumar, Andreu Porta-Sánchez Tags: Original Article Source Type: research
Selective Blockade of Interleukin-6 Trans-signaling
Atrial fibrillation (AF) has been accepted as an inflammatory atrial myopathy. Interleukin 6 (IL-6)-dependent inflammatory signaling pathways take context-dependent effects on cardiovascular diseases. The IL-6 trans-signaling is predominantly pro-inflammatory. However, its effect on AF is unclear.
Source: Heart Rhythm - August 24, 2023 Category: Cardiology Authors: Xintao Li, Xiaoyu Wu, Xiaoqiang Chen, Shi Peng, Songwen Chen, Genqing Zhou, Yong Wei, Xiaofeng Lu, Changzuan Zhou, Yutong Ye, Jun Li, Shaowen Liu, Juan Xu Source Type: research
Selective blockade of interleukin 6 trans-signaling depresses atrial fibrillation
Atrial fibrillation (AF) has been accepted as an inflammatory atrial myopathy. Interleukin 6 (IL-6) –dependent inflammatory signaling pathways take context-dependent effects on cardiovascular diseases. IL-6 trans-signaling is predominantly pro-inflammatory. However, its effect on AF is unclear.
Source: Heart Rhythm - August 24, 2023 Category: Cardiology Authors: Xintao Li, Xiaoyu Wu, Xiaoqiang Chen, Shi Peng, Songwen Chen, Genqing Zhou, Yong Wei, Xiaofeng Lu, Changzuan Zhou, Yutong Ye, Jun Li, Shaowen Liu, Juan Xu Source Type: research
Cell-free DNA as an potential marker of statin induced muscle injury
Background and Aims: The most commonly reported undesirable side effects of statin treatment are myalgia and myopathy. Short DNA fragments freely present in plasma (cfDNA) and potentially released from stressed and damaged muscle tissue could be important marker of such complications.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: J. Hubacek, P. Huckova, D. Dlouha, V. Adamkova, M. Vrablik Source Type: research
Atrial Myopathy and Ischemic Stroke in Heart Failure With Preserved Ejection Fraction
We examined the hypothesis that atrial myopathy may be associated with ischemic stroke in patients with heart failure with preserved ejection fraction. This is an exploratory, post hoc analysis of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial. Patients with sinus rhythm documented at baseline electrocardiogram and without known AF were included in this analysis.
Source: The American Journal of Cardiology - July 27, 2023 Category: Cardiology Authors: Kassem Farhat, Khaled Elkholey, Zain Ul Abideen Asad, Stavros Stavrakis Source Type: research
Assessing atrial myopathy with cardiac magnetic resonance imaging in embolic stroke of undetermined source
Left atrial myopathy has been implicated in atrial fibrillation (AF)-related stroke and embolic stroke of undetermined source (ESUS).
Source: International Journal of Cardiology - July 25, 2023 Category: Cardiology Authors: Stavroula Papapostolou, John Kearns, Benedict T. Costello, Jessica O'Brien, Murray Rudman, Mark C. Thompson, Geoffrey Cloud, Dion Stub, Andrew J. Taylor Source Type: research
The association between C-peptide and atrial cardiomyopathy in nondiabetic adults: results from NHANES III
AbstractSerum C-peptide exhibits various biological activities. The relationship between C-peptide and atrial cardiomyopathy remains unknown. We aimed to investigate the association between C-peptide level and atrial cardiomyopathy in nondiabetic adults. Our study enrolled 4578 participants without diagnosed diabetes from the Third National Health and Nutrition Examination Survey (NHANES III). Atrial cardiomyopathy was defined as a deep terminal negative P wave in V1 below − 100 µV (more negative), according to the electrocardiogram. The participants were categorized into low C-peptide (≤ 1.46 nmol/L) and high C-...
Source: Heart and Vessels - July 15, 2023 Category: Cardiology Source Type: research
