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Total 19 results found since Jan 2013.

The role of potassium in muscle membrane dysfunction in end-stage renal disease
CONCLUSIONS: In ESRD patients, the muscle membrane is depolarized, mainly due to hyperkalemia.SIGNIFICANCE: Since normal muscle fatigue has been attributed to potassium-induced depolarization, it seems likely that this mechanism is also a major cause of the exaggerated muscle fatigue and weakness in ESRD patients.PMID:34740043 | DOI:10.1016/j.clinph.2021.09.012
Source: Clinical Neurophysiology - November 5, 2021 Category: Neurology Authors: Lotte Hardbo Larsen Werner J Z'Graggen Hugh Bostock S Veronica Tan Niels Henrik Buus Hatice Tankisi Source Type: research

Statin-Associated Necrotizing Myopathy Leading to Acute Kidney Injury: A Case Report
We present a case of a female patient who was on chronic rosuvastatin therapy and developed necrotizing myopathy. The disease progressed to acute kidney and liver injury. We discontinued the drug, started supportive measures, and initiated renal replacement therapy with a high cutoff dialysis membrane once. Her recovery was prompt, with a normal control electromyography 2 weeks after discharge.Case Rep Nephrol Dial 2021;11:129 –135
Source: Case Reports in Nephrology and Dialysis - June 17, 2021 Category: Urology & Nephrology Source Type: research

Rosuvastatin-induced rhabdomyolysis: A case report
In this report, we have also discussed the various risk factors for developing myopathy with statins and the importance of strict pharmacovigilance, and a greater caution among physicians while using this drug.
Source: Indian Journal of Nephrology - April 20, 2021 Category: Urology & Nephrology Authors: Ravindra Nikalji Suvadeep Sen Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Renal Involvement in Neuropathy, Ataxia, Retinitis Pigmentosa (NARP) Syndrome: A Case Report
We report a case of a patient who had the mitochondrial cytopathy complex of neuropathy, ataxia, and retinitis pigmentosa (NARP) syndrome diagnosed at age 11 years with a biopsy-proven kidney involvement that progressed to end-stage renal disease at age 21 years. Mutations of mitochondrial DNA (mtDNA) are maternally inherited and lead to mitochondrial cytopathies with predominant neurologic manifestations: psychomotor retardation, epilepsy, ataxia, neuropathy, and myopathy. Given the ubiquitous nature of mitochondria, cellular dysfunction can also appear in tissues with high metabolic turnover; thus, there can be cardiac, ...
Source: American Journal of Kidney Diseases - December 16, 2017 Category: Urology & Nephrology Source Type: research

Ischemic myopathy revealing systemic calciphylaxis
This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - December 8, 2016 Category: Internal Medicine Authors: Jessie Aouizerate, Laurence Valleyrie ‐Allanore, Nicolas Limal, S. Samar Ayache, Romain K. Gherardi, Vincent Audard, François Jérôme Authier Tags: Research Article Source Type: research

Opinions of nephrologists on the efficacy and tolerance of statins in hemodialysis patients.
Authors: Budzisz E, Nowicki M Abstract Large randomized controlled trials have not confirmed the effects of statin therapy on reduction of cardiovascular morbidity and mortality in end-stage kidney disease, despite that statins are still widely prescribed by nephrologists to chronic dialysis patients. The aim of the study was to analyze the attitudes of nephrologists towards statin use in hemodialysis patients. Self-designed questionnaire, containing 18 questions, was distributed among 115 nephrologists. The survey contained description of the results of 3 largest statin trials in nephrology. The questions referred...
Source: Renal Failure - November 26, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Severe rhabdomyolysis secondary to adenovirus infection: case report and literature review.
Abstract A 38-year-old male presented with renal failure in the setting of a flu-like illness. Urinalysis showed myoglobinuria and granular casts. His serum creatine phosphokinase was markedly elevated. He was diagnosed with rhabdomyolysis and was volume resuscitated with normal saline and bicarbonate-containing fluid. Workup included a respiratory viral panel which was positive for adenovirus. Other causes such as trauma, seizure, and intoxicants were excluded. He developed progressive renal failure necessitating hemodialysis. After ~ 4 weeks he recovered renal function and dialysis was discontinued. Viral-induce...
Source: Clinical Nephrology - February 9, 2016 Category: Urology & Nephrology Authors: Tseytlin D, Maynard S Tags: Clin Nephrol Source Type: research

Detection of Left Atrium Myopathy Using Two‐Dimensional Speckle Tracking Echocardiography in Patients with End‐Stage Renal Disease on Dialysis Therapy
ConclusionAssessment of LA deformation parameters predicts LV diastolic dysfunction and right ventricle systolic pressure in dialysis patients. Left atrium function in dialysis patients was impaired before the occurrence of left atrium dilatation.
Source: Echocardiography - December 13, 2015 Category: Cardiology Authors: Noha Hassanin, Alkhateeb Alkemary Tags: Original Investigation Source Type: research

Casq Mutants Linked to Human Skeletal Myopathies Protein Structure and Folding
Calsequestrin 1 is the principal Ca2+ storage protein of the sarcoplasmic reticulum of skeletal muscle. Its inheritable D244G mutation causes a myopathy with vacuolar aggregates, whereas its M87T “variant” is weakly associated with malignant hyperthermia. We characterized the consequences of these mutations with studies of the human proteins in vitro. Equilibrium dialysis and turbidity measurements showed that D244G and, to a lesser extent, M87T partially lose Ca2+ binding exhibited by wild type calsequestrin 1 at high Ca2+ concentrations. D244G aggregates abruptly and abnormally, a property that fully explains the pro...
Source: Journal of Biological Chemistry - November 27, 2015 Category: Chemistry Authors: Lewis, K. M., Ronish, L. A., Rios, E., Kang, C. Tags: Molecular Bases of Disease Source Type: research

Sarcopenia or uremic myopathy in CKD patients.
Abstract Often underestimated or misunderstood in chronic renal failure (CRF), muscle wasting is nevertheless common and concerns about 50% of dialysis patients. The consequences of this myopathy on quality of life and outcomes of patients are unfavorable, identical to those observed in sarcopenia in elderly subjects with sarcopenia. The similarities between the two situations also concern the symptoms, the underlying muscle damages and the pathogenic mechanisms and may be partly explained by the frequently high age of ESRD patients. Skeletal muscle involvement should be systematically investigated in the IRC pati...
Source: Nephrologie and Therapeutique - November 17, 2015 Category: Urology & Nephrology Authors: Chauveau P, Moreau K, Lasseur C, Fouque D, Combe C, Aparicio M Tags: Nephrol Ther Source Type: research

The Role of Deconditioning in the End-Stage Renal Disease Myopathy: Physical Exercise Improves Altered Resting Muscle Oxygen Consumption
Background: Skeletal muscle dysfunction and poor exercise tolerance are hallmarks of end-stage renal disease (ESRD). Noninvasively measured (near-infrared spectroscopy, NIRS) resting muscle oxygen consumption (rmVO2) is a biomarker of muscle dysfunction, which can be applied to study the severity and the reversibility of ESRD myopathy. We tested the hypothesis that deconditioning is a relevant factor in ESRD myopathy. Methods: The whole dialysis population (n = 59) of two of the eight centers participating into the EXCITE study (ClinicalTrials.gov NCT01255969), a randomized trial evaluating the effect of a home-based exerc...
Source: American Journal of Nephrology - June 15, 2015 Category: Neurology Source Type: research

The Role of Deconditioning in the End-Stage Renal Disease Myopathy: Physical Exercise Improves Altered Resting Muscle Oxygen Consumption.
CONCLUSION: Deconditioning has a major role in ESRD myopathy. rmVO2 is a marker of physical deconditioning and has the potential for monitoring re-conditioning programs based on physical exercise in the ESRD population. © 2015 S. Karger AG, Basel. PMID: 26067552 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - June 11, 2015 Category: Urology & Nephrology Authors: Manfredini F, Lamberti N, Malagoni AM, Felisatti M, Zuccalà A, Torino C, Tripepi G, Catizone L, Mallamaci F, Zoccali C Tags: Am J Nephrol Source Type: research