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Cancer: Breast Cancer
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Total 63039 results found since Jan 2013.
Real-world evidence of neoadjuvant chemotherapy for breast cancer treatment in a Brazilian multicenter cohort: Correlation of pathological complete response with overall survival
CONCLUSION: The pCR rate and its prognostic value varied across BC subtypes. In our study, pCR could be used as a surrogate of favorable clinical outcome, as it was associated with higher OS and DFS rates.PMID:37722319 | DOI:10.1016/j.breast.2023.103577
Source: Breast - September 18, 2023 Category: Cancer & Oncology Authors: Marcelo Antonini Andr é Mattar Fernanda Grace Bauk Richter Gabriel Duque Pannain Marina Di ógenes Teixeira Andressa Gon çalves Amorim Odair Ferraro Reginaldo Coelho Guedes Lopes Luiz Henrique Gebrim Juliana Monte Real Source Type: research
Erratum to: Comprehensive serum lipidomic analyses reveal potential biomarkers for malignant breast cancer: A case-control study
Cancer Biomark. 2023 Sep 14. doi: 10.3233/CBM-239003. Online ahead of print.NO ABSTRACTPMID:37718782 | DOI:10.3233/CBM-239003
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Source Type: research
The relationship between tissue differentiation-inducing non-protein coding RNA expression and tumor size in patients with breast cancer
This study aimed to evaluate the expression level of Tissue Differentiation-Inducing Non-Protein Coding RNA (TINCR) in adjacent tumor and non-tumor tissues of 60 women with invasive ductal breast cancer. The relationship between TINCR expression and the clinical characteristics of patients has also been studied. For this purpose, total RNA was isolated from breast cancer patients' adjacent tumor and non-tumor tissue. RT Prime Script reagent was then used to convert total RNA to cDNA. The qRT-PCR quantified the TINCR expression level and analyzed the results by paired t-test. In addition, ROC curve analysis was used to eval...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Shen Tan Aimin Cui Nan Bai Zicui Zhang Source Type: research
Three cases of colon cancer in four generations of the Saudi family, caused by endogamous germline mutations
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):163-171. doi: 10.14715/cmb/2023.69.8.25.ABSTRACTVarious research pieces of evidence have been published in recent years, establishing the increasing prevalence of early colon cancer among young people. In this background, the current study aimed to analyze the reasons behind colon cancer recurrence among endogamous consanguineous cases in four generations of a single Saud family. For this study, the authors conducted the whole-exome sequencing analysis to screen for germline mutations in DNA samples from consanguineous cases within the family. After collecting the colon sam...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Dalal S Alshaya Tahani Mohamed Ibrahim Al-Hazani Mashael Alhumaidi Alotaibi Dalia Mostafa Domiaty Eman Alshehri Maha Abdulla Alwaili Amani Mohammed Alotaibi Areej Saud Jalal Alaa Ali AlQahtani Fatima Abdullah AlQassim Gadah Albasher Wedad Saeed Al-Qahtani Source Type: research
Imaging immune checkpoint networks in cancer tissues with supermultiplexed SERS nanoprobes
Biomaterials. 2023 Sep 12;302:122327. doi: 10.1016/j.biomaterials.2023.122327. Online ahead of print.ABSTRACTCombined immune checkpoint (ICP) inhibitors maximize immune response rates of patients compared to the single-drug treatment strategy in cancer immunotherapy, and prediction of such optimal combinations requires high-throughput imaging techniques and suitable data analysis. In this work, we report a rational strategy for predicting combined drugs of ICP inhibitors based on supermultiplexed surface-enhanced Raman scattering (SERS) imaging and correlation network analysis. To this end, we first built an ultrasensitive...
Source: Biomaterials - September 16, 2023 Category: Materials Science Authors: Jin Li Fugang Liu Xinyuan Bi Jian Ye Source Type: research
Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography
This study aims at demonstrating label-free drug-response-patterns assessment of different tumor spheroids and drug types by dynamic optical coherence tomography (D-OCT). The study involved human breast cancer (MCF-7) and colon cancer (HT-29) spheroids. The MCF-7 and HT-29 spheroids were treated with paclitaxel (Taxol; PTX) and the active metabolite of irinotecan SN-38, respectively. The drugs were applied with 0 (control), 0.1, 1, and 10 μM concentrations and the treatment durations were 1, 3, and 6 days. A swept-source OCT microscope equipped with a repeated raster scanning protocol was used to scan the spheroids. Logar...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Ibrahim Abd El-Sadek Larina Tzu-Wei Shen Tomoko Mori Shuichi Makita Pradipta Mukherjee Antonia Lichtenegger Satoshi Matsusaka Yoshiaki Yasuno Source Type: research
Delineation and detection of breast cancer using novel label-free fluorescence
CONCLUSIONS: This exploratory work presents a potential avenue for improving "in-vivo" disease characterization using optical technology, specifically our LIF technique combined with the advanced K-mc approach, facilitating early tumor diagnosis in BC.PMID:37716994 | DOI:10.1186/s12880-023-01095-2
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Alaaeldin Mahmoud Yasser H El-Sharkawy Source Type: research
TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment
Mol Oncol. 2023 Sep 16. doi: 10.1002/1878-0261.13525. Online ahead of print.ABSTRACTThe core Hippo pathway module consists of a tumor-suppressive kinase cascade that inhibits the transcriptional coactivators Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1; also known as TAZ). When the Hippo pathway is downregulated, as often occurs in breast cancer, YAP/TAZ activity is induced. To elaborate the roles of TAZ in triple-negative breast cancer (TNBC), we depleted Taz in murine TNBC 4T1 cells, using either CRISPR/Cas9 or small hairpin RNA (shRNA). TAZ-depleted cells and their contr...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Anat Gershoni Ori Hassin Nishanth Belugali Nataraj Sivan Baruch Adi Avioz-Seligman Anna Chiara Pirona Liat Fellus-Alyagor Tomer Meir Salame Saptaparna Mukherjee Giuseppe Mallel Yosef Yarden Yael Aylon Moshe Oren Source Type: research
Interplay Between Estrogen, Kynurenine, and AHR Pathways: An Immunosuppressive Axis with Therapeutic Potential for Breast Cancer Treatment
Biochem Pharmacol. 2023 Sep 14:115804. doi: 10.1016/j.bcp.2023.115804. Online ahead of print.ABSTRACTBreast cancer is one of the most common malignancies among women worldwide. Estrogen exposure via endogenous and exogenous sources during a lifetime, together with environmental exposure to estrogenic compounds, represent the most significant risk factor for breast cancer development. As breast tumors establish, multiple pathways are deregulated. Among them is the aryl hydrocarbon receptor (AHR) signaling pathway. AHR, a ligand-activated transcription factor associated with the metabolism of polycyclic aromatic hydrocarbons...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Jorge Humberto Lim ón Pacheco Guillermo Elizondo Source Type: research
Additional intraoperative subpectoral plane block vs conventional pain control: A comparison of shoulder movement in patients with mastectomy
CONCLUSIONS: Compared to conventional analgesia, intraoperative pectoral nerve block under direct vision enhances shoulder mobility in forward elevation, external rotation, and arm abduction after mastectomy in breast cancer patients.PMID:37716023 | DOI:10.1016/j.breast.2023.103579
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Sivaporn Pondeenana Chao Saenghirunvattana Patcharin Intarakhao Sorasit Inchan Panuwat Chuemor Atthakorn Jarusriwanna Source Type: research
Adjuvant olaparib - High risk early breast cancer with BRCA1 or BRCA2 germline mutation
Bull Cancer. 2023 Sep 14:S0007-4551(23)00340-5. doi: 10.1016/j.bulcan.2023.07.004. Online ahead of print.NO ABSTRACTPMID:37716861 | DOI:10.1016/j.bulcan.2023.07.004
Source: Bulletin du Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Ma ëva Bonneau Audrey Bellesoeur Source Type: research
The combination of the HDC1 inhibitor SAHA and doxorubicin has synergic efficacy in triple negative breast cancer in vivo
In this study, we investigated the synergistic potential of these two drugs in combination against TNBC. Our results suggested that the combination of these two drugs could enhance the inhibitory effect on cancer cell proliferation, resulting in alterations in cell mitotic phase, and suppression of cancer cell stemness. Moreover, our in vivo study unveiled that when SAHA was combined with DOX, it not only exhibited an inhibitory effect on tumor metastasis but also played a role in regulating the immune microenvironment within tumors. Overall, the combination of DOX and SAHA presents a promising avenue for innovative combin...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Yuheng Pang Runze Shi Liujia Chan Yu Lu Di Zhu Tong Liu Meisi Yan Yuji Wang Wenjing Wang Source Type: research
Additional intraoperative subpectoral plane block vs conventional pain control: A comparison of shoulder movement in patients with mastectomy
CONCLUSIONS: Compared to conventional analgesia, intraoperative pectoral nerve block under direct vision enhances shoulder mobility in forward elevation, external rotation, and arm abduction after mastectomy in breast cancer patients.PMID:37716023 | DOI:10.1016/j.breast.2023.103579
Source: Breast - September 16, 2023 Category: Cancer & Oncology Authors: Sivaporn Pondeenana Chao Saenghirunvattana Patcharin Intarakhao Sorasit Inchan Panuwat Chuemor Atthakorn Jarusriwanna Source Type: research
Low Expression of A3C and PLP2 Indicating a Favorable Prognosis in Human Gliomas
In conclusion, our results not only confirmed A3C played an important role in glioma development, but the A3C IHC test could successfully predict the therapeutic effects and disease prognosis.PMID:37715423 | DOI:10.14715/cmb/2023.69.7.12
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Jong-Shiaw Jin Yu-Ling Tsai Yu-Chan Chang Wen-Chiuan Tsai Source Type: research
Hsa-miR-497-3p impedes the proliferation and invasion of triple-negative breast cancer cells by controlling epithelial-mesenchymal transition through ZEB1 targeting
This study aimed to examine the hsa-miR-497-3p effect and mechanism on the behavior of triple-negative breast cancer (TNBC) cells. We evaluated the expression of Hsa-miR-497-3p in tissue samples obtained from patients diagnosed with TNBC or luminal breast cancer (BrCa), utilizing the quantitative fluorescence polymerase chain reaction (PCR) method. We transfected hsa-miR-497-3p mimics and NC into MDA-MB-231 cells, whilehsa-miR-497-3p inhibitor and NC into TNBC cells, respectively. To examine the impact of hsa-miR-497-3p expression level on TNBC cell proliferation, invasion, and migration, we employed MTT, clone formation, ...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Qian Dong Hu Chen Ying Li Yan Kong Cuizhi Geng Yibing Liu Source Type: research
