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Cancer: Breast Cancer
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Risk Factors for Breast Cancer-Related Lymphedema: An Umbrella Review
CONCLUSIONS: The currently identified risk factors for BCRL all are innate personal trait-related factors. Future well-designed studies and robust meta-analyses are needed to explore potential associations between behavioral-, interpersonal-, and environmental-related factors and BCRL, as well as the role of genetic variations and pathophysiologic factors.PMID:37725224 | DOI:10.1245/s10434-023-14277-7
Source: Ann Oncol - September 19, 2023 Category: Cancer & Oncology Authors: Aomei Shen Wanmin Qiang Liyuan Zhang Jingru Bian Fei Zhu Zijuan Zhang Qian Lu Source Type: research
RANK expression as an independent predictor for response to neoadjuvant chemotherapy in luminal-like breast cancer - a translational insight from the GeparX trial
CONCLUSIONS: We report RANK expression to be an independent predictive biomarker for response to NACT in luminal-like breast cancer patients.PMID:37725572 | DOI:10.1158/1078-0432.CCR-23-1801
Source: Clinical Genitourinary Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Theresa Link Jens-Uwe Blohmer Wolfgang D Schmitt Jan Dominik Kuhlmann Marianne Just Michael Untch Oliver Stotzer Peter A Fasching Marc Thill Mattea Reinisch Andreas Schneeweiss Pauline Wimberger Sabine Seiler Jens Huober Christian Jackisch Kerstin Rhiem C Source Type: research
Twenty-Year Follow-Up of a Phase II Trial of Taxotere/Carboplatin/Herceptin in Patients With Metastatic HER2-Positive Breast Cancer
CONCLUSION: A subset of patients (10%) receiving trastuzumab in the metastatic setting have achieved long-term survival beyond 20 years.PMID:37725049 | DOI:10.1093/oncolo/oyad258
Source: The Oncologist - September 19, 2023 Category: Cancer & Oncology Authors: Juan Luis Gomez Marti Azadeh Nasrazadani Ying Ding Daniel Normolle Adam M Brufsky Source Type: research
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research
Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery
CONCLUSIONS AND CLINICAL RELEVANCE: We characterized an extensive proteomic landscape of BrMs and gliomas. These findings have promising implications for the development of targeted therapies for BrMs and gliomas.PMID:37726528 | DOI:10.1002/prca.202300010
Source: Clinical Colorectal Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Shuang Yang Chengbin Zhou Lei Zhang Yueting Xiong Yongtao Zheng Liuguan Bian Xiaohui Liu Source Type: research
Accessory breast cancer: A case report and literature review of ultrasonographic findings
Australas J Dermatol. 2023 Sep 18. doi: 10.1111/ajd.14160. Online ahead of print.NO ABSTRACTPMID:37723873 | DOI:10.1111/ajd.14160
Source: The Australasian Journal of Dermatology - September 19, 2023 Category: Dermatology Authors: Kazuki Ichihashi Akimasa Adachi Yasuyuki Sawada Source Type: research
The quality and clinical translation of radiomics studies based on MRI for predicting Ki-67 levels in patients with breast cancer
CONCLUSION: Ki-67 index is a common tumor biomarker with high clinical value. Radiomics is an ever-growing quantitative data-mining method helping predict tumor biomarkers from medical images. However, the quality of the reviewed studies evaluated by the RQS was not so satisfactory and there are ample opportunities for improvement. Open science and data, external validation, phantom study, publicly open radiomics database and standardization in the radiomics practice are what researchers should pay more attention to in the future.ADVANCES IN KNOWLEDGE: The RQS tool considered the radiomics used to predict the Ki-67 level w...
Source: The British Journal of Radiology - September 19, 2023 Category: Radiology Authors: Min Wang Ting Mei Youling Gong Source Type: research
Accessory breast cancer: A case report and literature review of ultrasonographic findings
Australas J Dermatol. 2023 Sep 18. doi: 10.1111/ajd.14160. Online ahead of print.NO ABSTRACTPMID:37723873 | DOI:10.1111/ajd.14160
Source: The Australasian Journal of Dermatology - September 19, 2023 Category: Dermatology Authors: Kazuki Ichihashi Akimasa Adachi Yasuyuki Sawada Source Type: research
Quality of evidence supporting the role of acupuncture for breast cancer-related lymphoedema: an overview of systematic reviews and meta-analyses
CONCLUSIONS: Acupuncture may be beneficial in improving BCRL. However, due to the identified limitations and conflicting findings, further more prescriptive and rigorous SRs/MAs are required to give strong evidence for final judgments.PMID:37721568 | DOI:10.1007/s00432-023-05419-1
Source: Clinical Breast Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Lei Wang Xueyuan Du Peng Hu Yaling Zhang Mingchao Yao Xiaoling Che Source Type: research
The necessity of proactive measures from healthcare providers highlighted by delayed breast cancer diagnosis due to COVID-19: A case report
Clin Case Rep. 2023 Sep 15;11(9):e7919. doi: 10.1002/ccr3.7919. eCollection 2023 Sep.ABSTRACTKEY CLINICAL MESSAGE: During disasters, multiple factors can cause significant delays in medical visits. Regular patient monitoring, high-risk individual alerts, and telemedicine enhancements can potentially alleviate these issues and ensure timely interventions.ABSTRACT: During the COVID-19 pandemic, a Japanese woman in her 70s delayed her regular breast cancer checkup for over 2 years. During disasters, health priorities tend to decline, necessitating proactive measures from healthcare providers, such as augmenting collaboration ...
Source: Clinical Breast Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Yudai Kaneda Akihiko Ozaki Mira Namba Toyoaki Sawano Masahiro Wada Hiroaki Saito Yoshiaki Kanemoto Tomohiro Kurokawa Masaharu Tsubokura Kazunoshin Tachibana Tetsuya Tanimoto Tohru Ohtake Tomozo Ejiri Hiroaki Shimmura Norio Kanzaki Source Type: research
Enhanced Photoacoustic Imaging of Urokinase-Type Plasminogen Activator Activity in Tumors
Anal Chem. 2023 Sep 18. doi: 10.1021/acs.analchem.3c03305. Online ahead of print.ABSTRACTPhotoacoustic (PA) imaging of urokinase-type plasminogen activator (uPA) activity in vivo holds high promise for early diagnosis of breast cancer. Molecular probes with resisted fluorescence (FL) emission for enhanced PA signals of uPA activity have not been reported. Herein, we proposed a molecular probe Cbz-Gly-Gly-Arg-Phe-Phe-IR775 (Z-GGRFF-IR775) which, upon uPA cleavage, assembled into nanoparticles FF-IR775-NP with quenched fluorescence but enhanced PA signals. Experimental results validated that, upon uPA activation, Z-GGRFF-IR7...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Xinyi Hu Xianbao Sun Xiaoyang Liu Hai-Dong Xu Liang Yang Songqin Liu Rui Wang Gaolin Liang Source Type: research
Quality of evidence supporting the role of acupuncture for breast cancer-related lymphoedema: an overview of systematic reviews and meta-analyses
CONCLUSIONS: Acupuncture may be beneficial in improving BCRL. However, due to the identified limitations and conflicting findings, further more prescriptive and rigorous SRs/MAs are required to give strong evidence for final judgments.PMID:37721568 | DOI:10.1007/s00432-023-05419-1
Source: Clinical Genitourinary Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Lei Wang Xueyuan Du Peng Hu Yaling Zhang Mingchao Yao Xiaoling Che Source Type: research
The necessity of proactive measures from healthcare providers highlighted by delayed breast cancer diagnosis due to COVID-19: A case report
Clin Case Rep. 2023 Sep 15;11(9):e7919. doi: 10.1002/ccr3.7919. eCollection 2023 Sep.ABSTRACTKEY CLINICAL MESSAGE: During disasters, multiple factors can cause significant delays in medical visits. Regular patient monitoring, high-risk individual alerts, and telemedicine enhancements can potentially alleviate these issues and ensure timely interventions.ABSTRACT: During the COVID-19 pandemic, a Japanese woman in her 70s delayed her regular breast cancer checkup for over 2 years. During disasters, health priorities tend to decline, necessitating proactive measures from healthcare providers, such as augmenting collaboration ...
Source: Clinical Genitourinary Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Yudai Kaneda Akihiko Ozaki Mira Namba Toyoaki Sawano Masahiro Wada Hiroaki Saito Yoshiaki Kanemoto Tomohiro Kurokawa Masaharu Tsubokura Kazunoshin Tachibana Tetsuya Tanimoto Tohru Ohtake Tomozo Ejiri Hiroaki Shimmura Norio Kanzaki Source Type: research
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer
Res Sq. 2023 Sep 8:rs.3.rs-3266720. doi: 10.21203/rs.3.rs-3266720/v1. Preprint.ABSTRACTThe alternative splicing of PML precursor mRNA gives rise to various PML isoforms, yet their expression profile in breast cancer cells remains uncharted. We discovered that PML1 is the most abundant isoform in all breast cancer subtypes, and its expression is associated with unfavorable prognosis in estrogen receptor-positive (ER+) breast cancers. PML depletion reduces cell proliferation, invasion, and stemness, while heterologous PML1 expression augments these processes and fuels tumor growth and resistance to fulvestrant, an FDA-approv...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Hung-Ying Kao Chun-Peng Pai Han Wang Neel Agarwal Joshua Adams Zhenghao Liu Darcie Seachrist Ruth Keri William Schiemann Source Type: research
Erratum to: Comprehensive serum lipidomic analyses reveal potential biomarkers for malignant breast cancer: A case-control study
Cancer Biomark. 2023 Sep 14. doi: 10.3233/CBM-239003. Online ahead of print.NO ABSTRACTPMID:37718782 | DOI:10.3233/CBM-239003
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Source Type: research
