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Cancer: Squamous Cell Carcinoma
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Total 19265 results found since Jan 2013.
Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells
In conclusion, IFI6 plays a positive role in the proliferation of ESCC cells both in vitro and in vivo, which could be a novel therapeutic target for treating ESCC.PMID:37661181 | DOI:10.26402/jpp.2023.3.04
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: Y Gao J Dai X P Xu P F Liu R H Shi Source Type: research
Cancers, Vol. 15, Pages 4405: Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide
Maria Paula Curado
Head and neck cancer (HNC) treatments have been based on single or multimodal therapies with surgery, radiotherapy (RT), chemotherapy, and immunotherapy. However, treatment recommendations among countries may differ due to technological/human resources and usual local practices. This scoping review aims to identify, compare, and map the clinical practice guidelines (CPGs) for treating squamous cell carcinoma (SCC) of the oral cavity, oropharynx, and larynx worldwide. A search strategy on global CPGs for HNC was performed by using five electronic databases and grey literature. CPGs were selected for ...
Source: Cancers - September 3, 2023 Category: Cancer & Oncology Authors: Lady Paola Aristizabal Arboleda Genival Barbosa de Carvalho Alan Roger Santos-Silva Gisele Aparecida Fernandes Jose Guilherme Vartanian David I. Conway Shama Virani Paul Brennan Luiz Paulo Kowalski Maria Paula Curado Tags: Systematic Review Source Type: research
Accounting for fractionation and heterogeneous dose distributions in the modelling of osteoradionecrosis in oropharyngeal carcinoma treatment
CONCLUSION: Risk models for ORN based on conventional DVH parameters cannot be directly applied to HF-SBRT fractionation schemes and dose distributions. However, after correcting for fractionation and non-uniform dose distributions using EUD, a single model can distinguish between ORN and non-ORN after conventionally fractionated radiotherapy and hypofractionated boost treatments.PMID:37659662 | DOI:10.1016/j.radonc.2023.109889
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 2, 2023 Category: Radiology Authors: Gerda M Verduijn Nienke D Sijtsema Yvette van Norden Wilma D Heemsbergen Hetty Mast Aniel Sewnaik Denzel Chin Sarah Baker Marta E Capala Aad van der Lugt Esther van Meerten Mischa S Hoogeman Steven F Petit Source Type: research
Prognostic biomarker SPP1 in head and neck squamous cell carcinoma
Asian J Surg. 2023 Aug 31:S1015-9584(23)01355-6. doi: 10.1016/j.asjsur.2023.08.182. Online ahead of print.NO ABSTRACTPMID:37659924 | DOI:10.1016/j.asjsur.2023.08.182
Source: Asian Journal of Surgery - September 2, 2023 Category: Surgery Authors: Linghan Meng Yishimei Si Bingwen Zhang Jianwei Qi Source Type: research
Accounting for fractionation and heterogeneous dose distributions in the modelling of osteoradionecrosis in oropharyngeal carcinoma treatment
CONCLUSION: Risk models for ORN based on conventional DVH parameters cannot be directly applied to HF-SBRT fractionation schemes and dose distributions. However, after correcting for fractionation and non-uniform dose distributions using EUD, a single model can distinguish between ORN and non-ORN after conventionally fractionated radiotherapy and hypofractionated boost treatments.PMID:37659662 | DOI:10.1016/j.radonc.2023.109889
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 2, 2023 Category: Radiology Authors: Gerda M Verduijn Nienke D Sijtsema Yvette van Norden Wilma D Heemsbergen Hetty Mast Aniel Sewnaik Denzel Chin Sarah Baker Marta E Capala Aad van der Lugt Esther van Meerten Mischa S Hoogeman Steven F Petit Source Type: research
Prognostic biomarker SPP1 in head and neck squamous cell carcinoma
Asian J Surg. 2023 Aug 31:S1015-9584(23)01355-6. doi: 10.1016/j.asjsur.2023.08.182. Online ahead of print.NO ABSTRACTPMID:37659924 | DOI:10.1016/j.asjsur.2023.08.182
Source: Asian Journal of Surgery - September 2, 2023 Category: Surgery Authors: Linghan Meng Yishimei Si Bingwen Zhang Jianwei Qi Source Type: research
Salivary vitamin D levels among OSCC and normal Indian patients
Bioinformation. 2022 Oct 31;18(10):884-887. doi: 10.6026/97320630018884. eCollection 2022.ABSTRACTOral Squamous Cell Carcinoma comprises nearly 90% of all Oral cancers. Recent studies on Oral Squamous Cell Carcinoma are done with a focus on identification of factors that affect the outcome of treatment, one of which is vitamin D levels. The aim of this study was to evaluate vitamin D3 levels in patients with Oral Squamous Cell Carcinoma and Normal Population with saliva as a biomarker. The study sample comprised of 40 subjects, of whom 20 were patients diagnosed with OSCC and 20 healthy subjects. The salivary samples obtai...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Sandra Sagar Pratibha Raman S Gheena R Abilasha Reshma Poothakulath Krishnan J Selvaraj Source Type: research
Whole-genome CpG-resolution DNA Methylation Profiling of HNSCC Reveals Distinct Mechanisms of Carcinogenesis for Fine-scale HPV+ Cancer Subtypes
This study revealed that the previously observed hypermethylation of HPV(+) HNSCC is due solely to the IMU subtype, illustrating the importance of fine-scale subtype analysis in such a heterogeneous disease. Particularly, IMU has significantly higher methylation of transposable elements, which can be tested as a prognosis biomarker in future translational studies.PMID:37654626 | PMC:PMC10467604 | DOI:10.1158/2767-9764.CRC-23-0009
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Tingting Qin Shiting Li Leanne E Henry Elysia Chou Raymond G Cavalcante Bailey F Garb Nisha J D'Silva Laura S Rozek Maureen A Sartor Source Type: research
MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma
This study aimed to investigate the function of miR-5189-3p in laryngeal squamous cell carcinoma (LSCC) and explore its underlying mechanisms. qRT-PCR was designed to determine the expression levels of miR-5189-3p and eukaryotic translation initiation factor 5A2 (EIF5A2), while CCK-8 assay was performed to measure the effects of miR-5189-3p on cell proliferation. Transwell assay was performed to evaluate cell invasion as well as migration, and wound healing assay was applied to demonstrate cell migratory ability. Target gene prediction and luciferase reporter assay were developed to screen the possible target gene of miR-5...
Source: Biochemical Genetics - September 1, 2023 Category: Genetics & Stem Cells Authors: Dan Lou Qiaojing Jia Haizhong Zhang Jingmiao Wang Lisha Liu Zhichang Liu Xiaofang Jia Jianxing Wang Chunguang Shan Source Type: research
Radiation-sensitive genetic prognostic model identifies individuals at risk for radiation resistance in head and neck squamous cell carcinoma
CONCLUSIONS: Our prognostic model based on a radiation-related gene signature has potential for application as a tool for risk stratification of radiation therapy for patients with HNSCC, helping to identify candidates for radiation therapy and overcome radiation resistance.PMID:37656244 | DOI:10.1007/s00432-023-05304-x
Source: Clinical Lung Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Peimeng You Shengbo Liu Qiaxuan Li Daipeng Xie Lintong Yao Chenguang Guo Zefeng Guo Ting Wang Hongrui Qiu Yangzhong Guo Junyu Li Haiyu Zhou Source Type: research
Homeobox-D 1 and FTO form a transcriptional-epigenetic feedback loop to promote head and neck cancer proliferation
In this study, we demonstrate that the TF homeobox-D1 (HOXD1) and the m6A demethylase fat mass and obesity-associated protein (FTO) form a positive feedback loop to promote cell proliferation and survival in HNSC. Clinically, HOXD1 expression is dysregulated in multiple cancer types and is associated with worse prognosis in patients with HNSC, stomach adenocarcinoma, uterine corpus endometrial carcinoma, and pheochromocytoma and paraganglioma. Mechanistically, FTO is overexpressed in HNSC tumor samples and positively regulates HOXD1 expression in an m6A-dependent manner. Functionally, deficiency of HOXD1 relieved the resis...
Source: Cell Biology International - September 1, 2023 Category: Cytology Authors: Chunyan Zhang Linsen Xie Zhen Lin Source Type: research
