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Cancer: Squamous Cell Carcinoma
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Total 19265 results found since Jan 2013.
Headache rounds: Postural headache in a patient with squamous cell carcinoma
Headache. 2023 Aug 27. doi: 10.1111/head.14615. Online ahead of print.NO ABSTRACTPMID:37635384 | DOI:10.1111/head.14615
Source: Headache - August 28, 2023 Category: Neurology Authors: Sayi P Boddu Brent P Goodman Juliana H VanderPluym Source Type: research
Overexpression of POFUT1 promotes malignant phenotype and mediates perineural invasion in head and neck squamous cell carcinoma
In this study, in silico analyses referred POFUT1 as a potential oncogene in HNSCC. Further analysis of tumor and normal tissue samples as well as HNSCC cells with quantitative real-time polymerase chain reaction, Western blot analysis, and immunohistochemistry showed significant overexpression of POFUT1 in HNSCC clinical tumor tissue specimens and cell lines compared to corresponding controls. In vitro investigations revealed that overexpression of POFUT1 promoted phenotypes associated with cancer aggressiveness and its knockdown in HNSCC cells suppressed those phenotypes. Further xenograft experiments demonstrated that P...
Source: Cell Biology International - August 28, 2023 Category: Cytology Authors: Neslisah Barlak Gulnur Kusdemir Rasim Gumus Betul Gundogdu Mehmet Hakan Sahin Arzu Tatar Michael Ittmann Omer Faruk Karatas Source Type: research
Epithelial-to-mesenchymal transition status correlated with ultrastructural features, and TP53 mutation in patient-derived oral cancer cell lines
CONCLUSIONS: Cellular migratory properties are associated with cellular ultrastructure, epithelial-to-mesenchymal transition status and the status of TP53 mutation in the genome.PMID:37639153 | DOI:10.1007/s11033-023-08720-x
Source: Molecular Biology Reports - August 28, 2023 Category: Molecular Biology Authors: Sushant S Navarange Sanjay M Bane Darshan Mehta Sanket Shah Sanjay Gupta Sanjeev K Waghmare Source Type: research
GRP78 is Overexpressed in Non-small Cell Lung Cancer Tissues and is Associated with High VEGF Expression in Squamous Cell Carcinoma: A Pilot Study
CONCLUSION: GRP78 overexpression was revealed in most of the investigated samples. The positive association between VEGF and GRP78 may indicate the proangiogenic role of GRP78 in lung cancer. Moreover, the positive association between VEGF and CD31 expression levels suggests that VEGF may cooperate with CD31 to promote angiogenesis in NSCLC.PMID:37638596 | DOI:10.2174/1568009623666230418111020
Source: Current Cancer Drug Targets - August 28, 2023 Category: Cancer & Oncology Authors: Maha Al-Keilani Mohammad A Alqudah Basima Almomani Moath M Alrjoub Batool A Shhabat Karem Alzoubi Source Type: research
TRIM32 promotes oral squamous cell carcinoma progression by enhancing FBP2 ubiquitination and degradation
Biochem Biophys Res Commun. 2023 Aug 18;678:165-172. doi: 10.1016/j.bbrc.2023.08.030. Online ahead of print.ABSTRACTThe aberrant expression of TRIM32, an E3 ubiquitin ligase, has been identified in multiple malignant cancer types. Nevertheless, the functional roles and detailed mechanisms of TRIM32 in oral squamous cell carcinoma (OSCC) remain to be elucidated. Here, we investigated TRIM32 expression and its functional role in OSCC. TRIM32 expression was consistently elevated in OSCC tissues, particularly in samples from patients with advanced clinical grades. Functionally, silencing TRIM32 dampened OSCC cell growth, migra...
Source: Biochemical and Biophysical Research communications - August 28, 2023 Category: Biochemistry Authors: Xiao Yang Haifeng Ma Min Zhang Renzhong Wang Xiaoyu Li Source Type: research
Global comparative transcriptomes uncover novel and population-specific gene expression in esophageal squamous cell carcinoma
CONCLUSION: This study provides new insights into population-specific differences in gene expression patterns and their associated pathways in ESCC. Our findings suggest that changes in extracellular matrix (ECM) organization may be crucial to the development and progression of this cancer, and that environmental and genetic factors play important roles in the disease. The novel DEGs identified may serve as potential biomarkers for diagnosis, prognosis and treatment.PMID:37641095 | DOI:10.1186/s13027-023-00525-8
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Amal Alotaibi Veerendra P Gadekar Pranav Swaroop Gundla Sumana Mandarthi Nidhi Jayendra Asna Tungekar B V Lavanya Ashok Kumar Bhagavath Mary Anne Wong Cordero Janne Pitkaniemi Shaik Kalimulla Niazi Raghavendra Upadhya Asmatanzeem Bepari Prashantha Hebbar Source Type: research
Epithelial-to-mesenchymal transition status correlated with ultrastructural features, and TP53 mutation in patient-derived oral cancer cell lines
CONCLUSIONS: Cellular migratory properties are associated with cellular ultrastructure, epithelial-to-mesenchymal transition status and the status of TP53 mutation in the genome.PMID:37639153 | DOI:10.1007/s11033-023-08720-x
Source: Mol Biol Cell - August 28, 2023 Category: Molecular Biology Authors: Sushant S Navarange Sanjay M Bane Darshan Mehta Sanket Shah Sanjay Gupta Sanjeev K Waghmare Source Type: research
Headache rounds: Postural headache in a patient with squamous cell carcinoma
Headache. 2023 Aug 27. doi: 10.1111/head.14615. Online ahead of print.NO ABSTRACTPMID:37635384 | DOI:10.1111/head.14615
Source: Headache - August 28, 2023 Category: Neurology Authors: Sayi P Boddu Brent P Goodman Juliana H VanderPluym Source Type: research
Epithelial-to-mesenchymal transition status correlated with ultrastructural features, and TP53 mutation in patient-derived oral cancer cell lines
CONCLUSIONS: Cellular migratory properties are associated with cellular ultrastructure, epithelial-to-mesenchymal transition status and the status of TP53 mutation in the genome.PMID:37639153 | DOI:10.1007/s11033-023-08720-x
Source: Mol Biol Cell - August 28, 2023 Category: Molecular Biology Authors: Sushant S Navarange Sanjay M Bane Darshan Mehta Sanket Shah Sanjay Gupta Sanjeev K Waghmare Source Type: research
Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients
CONCLUSIONS: Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.PMID:37639681 | DOI:10.1093/ajcp/aqad107
Source: American Journal of Clinical Pathology - August 28, 2023 Category: Pathology Authors: Anandi Lobo Sourav K Mishra Shilpy Jha Ankit Tiwari Rahul Kapoor Shivani Sharma Seema Kaushal N Sri Kiranmai M Rakshitha Das Kamal P Peddinti Shailendra K Sharma Nitin Bhardwaj Samriti Arora Deepika Jain Ekta Jain Gauri Munjal Sayali Shinde Vipra Malik He Source Type: research
Epithelial-to-mesenchymal transition status correlated with ultrastructural features, and TP53 mutation in patient-derived oral cancer cell lines
CONCLUSIONS: Cellular migratory properties are associated with cellular ultrastructure, epithelial-to-mesenchymal transition status and the status of TP53 mutation in the genome.PMID:37639153 | DOI:10.1007/s11033-023-08720-x
Source: Molecular Biology Reports - August 28, 2023 Category: Molecular Biology Authors: Sushant S Navarange Sanjay M Bane Darshan Mehta Sanket Shah Sanjay Gupta Sanjeev K Waghmare Source Type: research
TRIM32 promotes oral squamous cell carcinoma progression by enhancing FBP2 ubiquitination and degradation
Biochem Biophys Res Commun. 2023 Aug 18;678:165-172. doi: 10.1016/j.bbrc.2023.08.030. Online ahead of print.ABSTRACTThe aberrant expression of TRIM32, an E3 ubiquitin ligase, has been identified in multiple malignant cancer types. Nevertheless, the functional roles and detailed mechanisms of TRIM32 in oral squamous cell carcinoma (OSCC) remain to be elucidated. Here, we investigated TRIM32 expression and its functional role in OSCC. TRIM32 expression was consistently elevated in OSCC tissues, particularly in samples from patients with advanced clinical grades. Functionally, silencing TRIM32 dampened OSCC cell growth, migra...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Xiao Yang Haifeng Ma Min Zhang Renzhong Wang Xiaoyu Li Source Type: research
Cuproptosis-related LINC02454 as a biomarker for laryngeal squamous cell carcinoma based on a novel risk model and in vitro and in vivo analyses
CONCLUSIONS: A novel signature of four crlncRNAs was found to be highly accurate as a risk prediction model for patients with LSCC and to have potential for improving the diagnosis, prognosis, and treatment of LSCC.PMID:37639011 | DOI:10.1007/s00432-023-05281-1
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Qingwen Zhu Ruyue Zhang Fei Lu Xinyu Zhang Daidi Zhang Yaodong Zhang Erfang Chen Fugen Han DingJun Zha Source Type: research
GRP78 is Overexpressed in Non-small Cell Lung Cancer Tissues and is Associated with High VEGF Expression in Squamous Cell Carcinoma: A Pilot Study
CONCLUSION: GRP78 overexpression was revealed in most of the investigated samples. The positive association between VEGF and GRP78 may indicate the proangiogenic role of GRP78 in lung cancer. Moreover, the positive association between VEGF and CD31 expression levels suggests that VEGF may cooperate with CD31 to promote angiogenesis in NSCLC.PMID:37638596 | DOI:10.2174/1568009623666230418111020
Source: Current Cancer Drug Targets - August 28, 2023 Category: Cancer & Oncology Authors: Maha Al-Keilani Mohammad A Alqudah Basima Almomani Moath M Alrjoub Batool A Shhabat Karem Alzoubi Source Type: research
