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Cancer: Hepatocellular Carcinoma
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Total 31137 results found since Jan 2013.
PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma by Activating STAT3 Signaling Pathway
This study aims to explore the intrinsic mechanism of PIK3R6 and provide theoretical reference for the treatment of hepatocellular carcinoma.METHODS: Differential expressions of PIK in ovarian cancer and normal ones were detected by Western blotting and quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Analyze the relationship between the expression of PIK3R6 and patient prognosis through the TCGA database. Subsequently constructed corresponding stable cell lines, combined with transcriptome sequencing and several cell biology experiments, we explored the inner mechanism and clinical significance of PIK3R6.RESULT...
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Yanping Du Wenhui Zhao Hexu Han Lu Ren Mingdong Ding Yifan Wang Source Type: research
Synthesis and its characterisation of selenium/silver/chitosan and cellular toxicity against liver carcinoma cells studies
Nat Prod Res. 2023 Sep 14:1-9. doi: 10.1080/14786419.2023.2256023. Online ahead of print.ABSTRACTLiver cancer is one of the most common lethal malignancy in the world. To treat liver cancer, new cure options are crucial. The use of natural substances along nanosciences may provide healing with lower toxicity and a smaller amount of side properties. In this research, The three-component selenium-silver-chitosan nanocomposite (Se-Ag-CS NCs) were synthesised with the help of ultrasound in a stepwise manner. The as-synthesised Se-Ag-CS NCs were characterised accordingly by applying powder X-Ray diffraction (PXRD), Fourier tran...
Source: Natural Product Research - September 14, 2023 Category: Biochemistry Authors: Fateme Momen Eslamieh-Ei Negar Sharifimoghaddammood Samira Amin Poustchi Tousi Samira Basharkhah Javad Mottaghipisheh Ali Es-Haghi Mohammad Ehsan Taghavizadeh Yazdi Marcello Iriti Source Type: research
Lung immune prognostic index ‑based nomogram for recurrence of hepatocellular carcinoma after postoperative adjuvant TACE
CONCLUSION: Preoperative LIPI might be a powerful predictor for RFS in HCC patients received PA-TACE. The LIPI-based nomogram could further effectively predict the risk of recurrence and help clinicians formulate personalized follow-up strategies and adjuvant therapy to improve patient outcomes.PMID:37707573 | DOI:10.1007/s00432-023-05413-7
Source: Clin Med Res - September 14, 2023 Category: Research Authors: Yuxin Liang Ruoyi Yang Jin Shang Deyuan Zhong Qinyan Yang Yuhao Su Ying Shi Xiaolun Huang Source Type: research
PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma by Activating STAT3 Signaling Pathway
This study aims to explore the intrinsic mechanism of PIK3R6 and provide theoretical reference for the treatment of hepatocellular carcinoma.METHODS: Differential expressions of PIK in ovarian cancer and normal ones were detected by Western blotting and quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Analyze the relationship between the expression of PIK3R6 and patient prognosis through the TCGA database. Subsequently constructed corresponding stable cell lines, combined with transcriptome sequencing and several cell biology experiments, we explored the inner mechanism and clinical significance of PIK3R6.RESULT...
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Yanping Du Wenhui Zhao Hexu Han Lu Ren Mingdong Ding Yifan Wang Source Type: research
PYCR2 promotes growth and aerobic glycolysis in human liver cancer by regulating the AKT signaling pathway
Biochem Biophys Res Commun. 2023 Sep 9;680:15-24. doi: 10.1016/j.bbrc.2023.09.007. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the world's third most fatal cancer. Because metabolic rewiring is a hallmark of HCC, studies into the causes of aberrant glycolysis could provide insight into novel HCC therapeutic strategies. Pyrroline-5-carboxylate reductase 2 (PYCR2), a key enzyme of proline synthesis, has previously been found to play vital roles in various malignancies regarding amino acid metabolism and oxidative stress response. Our study investigated the mechanistic function of PYCR2 in HCC. We used Gen...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Shaoyan Wang Wenyan Yi Zhenyu Xu Minyu Shi Source Type: research
Lung immune prognostic index ‑based nomogram for recurrence of hepatocellular carcinoma after postoperative adjuvant TACE
CONCLUSION: Preoperative LIPI might be a powerful predictor for RFS in HCC patients received PA-TACE. The LIPI-based nomogram could further effectively predict the risk of recurrence and help clinicians formulate personalized follow-up strategies and adjuvant therapy to improve patient outcomes.PMID:37707573 | DOI:10.1007/s00432-023-05413-7
Source: Clin Med Res - September 14, 2023 Category: Research Authors: Yuxin Liang Ruoyi Yang Jin Shang Deyuan Zhong Qinyan Yang Yuhao Su Ying Shi Xiaolun Huang Source Type: research
PYCR2 promotes growth and aerobic glycolysis in human liver cancer by regulating the AKT signaling pathway
Biochem Biophys Res Commun. 2023 Sep 9;680:15-24. doi: 10.1016/j.bbrc.2023.09.007. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the world's third most fatal cancer. Because metabolic rewiring is a hallmark of HCC, studies into the causes of aberrant glycolysis could provide insight into novel HCC therapeutic strategies. Pyrroline-5-carboxylate reductase 2 (PYCR2), a key enzyme of proline synthesis, has previously been found to play vital roles in various malignancies regarding amino acid metabolism and oxidative stress response. Our study investigated the mechanistic function of PYCR2 in HCC. We used Gen...
Source: Biochemical and Biophysical Research communications - September 14, 2023 Category: Biochemistry Authors: Shaoyan Wang Wenyan Yi Zhenyu Xu Minyu Shi Source Type: research
PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma by Activating STAT3 Signaling Pathway
This study aims to explore the intrinsic mechanism of PIK3R6 and provide theoretical reference for the treatment of hepatocellular carcinoma.METHODS: Differential expressions of PIK in ovarian cancer and normal ones were detected by Western blotting and quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Analyze the relationship between the expression of PIK3R6 and patient prognosis through the TCGA database. Subsequently constructed corresponding stable cell lines, combined with transcriptome sequencing and several cell biology experiments, we explored the inner mechanism and clinical significance of PIK3R6.RESULT...
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Yanping Du Wenhui Zhao Hexu Han Lu Ren Mingdong Ding Yifan Wang Source Type: research
Clinical and prognostic significance of CCPG1 in hepatocellular carcinoma
This study aimed to examine the clinical and prognostic significance of cell-cycle progression gene 1 (CCPG1) in hepatocellular carcinoma (HCC). We firstly analyzed CCPG1 expression in various cancers using The Cancer Genome Atlas and the Genotype-Tissue Expression project databases. The relative expression levels of CCPG1 were determined in 164 paired HCC and adjacent tissues using immunohistochemistry. The correlation between CCPG1 and clinicopathological characteristics of HCC was analyzed. Cox proportional models were used to identify the prognostic factors for overall survival (OS) and disease-free survival (DFS). The...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Gangpu Wang Zhiqian Liu Qi Wang Bingqi Liu Jie Li Source Type: research
Validation of the albumin-bilirubin score for identifying decompensation risk in patients with compensated cirrhosis
CONCLUSION: The ALBI score accurately identifies decompensation risk at the 3-year follow-up in patients with compensated cirrhosis. Those cirrhotic patients with a high-risk grade of ALBI score showed a 23 times greater odds of decompensation.PMID:37701131 | PMC:PMC10494764 | DOI:10.3748/wjg.v29.i32.4873
Source: World Journal of Gastroenterology - September 13, 2023 Category: Gastroenterology Authors: Huttakan Navadurong Kessarin Thanapirom Salisa Wejnaruemarn Thaninee Prasoppokakorn Roongruedee Chaiteerakij Piyawat Komolmit Sombat Treeprasertsuk Source Type: research
