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Total 39172 results found since Jan 2013.
A computational investigation of occlusive arterial thrombosis
Biomech Model Mechanobiol. 2023 Sep 13. doi: 10.1007/s10237-023-01765-8. Online ahead of print.ABSTRACTThe generation of occlusive thrombi in stenotic arteries involves the rapid deposition of millions of circulating platelets under high shear flow. The process is mediated by the formation of molecular bonds of several distinct types between platelets; the bonds capture the moving platelets and stabilize the growing thrombi under flow. We investigated the mechanisms behind occlusive thrombosis in arteries with a two-phase continuum model. The model explicitly tracks the formation and rupture of the two types of interplatel...
Source: Biomechanics and Modeling in Mechanobiology - September 13, 2023 Category: Biomedical Science Authors: Jian Du Aaron L Fogelson Source Type: research
Avatrombopag for adult chronic primary immune thrombocytopenia: a randomized phase 3 trial in China
CONCLUSION: Avatrombopag was efficacious and generally well tolerated in Chinese patients with chronic primary ITP, with comparable efficacy and safety to previous reports in Western patients.PMID:37700877 | PMC:PMC10493258 | DOI:10.1016/j.rpth.2023.102158
Source: Thrombosis and Haemostasis - September 13, 2023 Category: Hematology Authors: Heng Mei Hu Zhou Ming Hou Jing Sun Lei Zhang Jianmin Luo Zhongxing Jiang Xu Ye Yajing Xu Jun Lu Hui Wang Aimin Hui Yongchun Zhou Yu Hu Source Type: research
Mitigating the risk of Tofacitinib-induced adverse events in the elderly population with Ulcerative Colitis
CONCLUSIONS: Modulation of induction dose and anti-thrombotic therapy may have contributed to prevent cardiologic events and thromboembolism. The introduction of zoster vaccine virtually eliminated zoster risk after the first cases. Potential malignancies deserve a careful work-up of older patients before treatment start.PMID:37702408 | DOI:10.1093/ecco-jcc/jjad158
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Anna Viola Raffaele Li Voti Chiara Bivacqua Clara de Francesco Marco Muscianisi Giuseppe Costantino Walter Fries Source Type: research
Avatrombopag for adult chronic primary immune thrombocytopenia: a randomized phase 3 trial in China
CONCLUSION: Avatrombopag was efficacious and generally well tolerated in Chinese patients with chronic primary ITP, with comparable efficacy and safety to previous reports in Western patients.PMID:37700877 | PMC:PMC10493258 | DOI:10.1016/j.rpth.2023.102158
Source: Thrombosis and Haemostasis - September 13, 2023 Category: Hematology Authors: Heng Mei Hu Zhou Ming Hou Jing Sun Lei Zhang Jianmin Luo Zhongxing Jiang Xu Ye Yajing Xu Jun Lu Hui Wang Aimin Hui Yongchun Zhou Yu Hu Source Type: research
Risk factors of worsening kidney function and mortality in patients with renal vein thrombosis: a retrospective study
CONCLUSION: Renal vein thrombosis is associated with a high rate of worsening kidney function and mortality. It is crucial to promptly identify patients at high risk and initiate early treatment to prevent negative outcomes.PMID:37702914 | DOI:10.1007/s40620-023-01761-2
Source: Journal of Nephrology - September 13, 2023 Category: Urology & Nephrology Authors: Puttinat Wanaratwichit Chatree Chai-Adisaksopha Nakarin Inmutto Kajohnsak Noppakun Source Type: research
A computational investigation of occlusive arterial thrombosis
Biomech Model Mechanobiol. 2023 Sep 13. doi: 10.1007/s10237-023-01765-8. Online ahead of print.ABSTRACTThe generation of occlusive thrombi in stenotic arteries involves the rapid deposition of millions of circulating platelets under high shear flow. The process is mediated by the formation of molecular bonds of several distinct types between platelets; the bonds capture the moving platelets and stabilize the growing thrombi under flow. We investigated the mechanisms behind occlusive thrombosis in arteries with a two-phase continuum model. The model explicitly tracks the formation and rupture of the two types of interplatel...
Source: Biomechanics and Modeling in Mechanobiology - September 13, 2023 Category: Biomedical Science Authors: Jian Du Aaron L Fogelson Source Type: research
Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
Life Sci Alliance. 2023 Sep 12;6(11):e202302106. doi: 10.26508/lsa.202302106. Print 2023 Nov.ABSTRACTPreviously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyperinflammation is dependent on high levels of anti-spike IgG with aberrant Fc tail glycosylation, leading to Fcγ receptor hyperactivation. For development of immune-regulatory therapeutics, drug specificity is crucial to counteract excessive inflammation whereas simulta...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Chiara E Geyer Hung-Jen Chen Alexander P Bye Xue D Manz Denise Guerra Tom G Caniels Tom Pl Bijl Guillermo R Griffith Willianne Hoepel Steven W de Taeye Jennifer Veth Alexander Pj Vlaar Amsterdam UMC COVID-19 Biobank Gestur Vidarsson Harm Jan Bogaard Jurja Source Type: research
Platelet Aggregation is not Altered in Men with Aortic Aneurysms
This study found no higher platelet aggregation or increased frequencies of hyperresponsiveness of platelets in patients with ascending and abdominal aortic dilations.PMID:37699517 | DOI:10.1055/a-2174-0844
Source: Thrombosis and Haemostasis - September 12, 2023 Category: Hematology Authors: Lasse M Obel Jes Sanddal Lindholt Axel Cosmus Pyndt Diederichsen Christian Kring Lars Melholt Rasmussen Anne Alnor Pernille Just Vinholt Source Type: research
A New Chapter Regarding Thrombosis Risk Assessment In Total Joint Replacement Patients
Thromb Haemost. 2023 Sep 12. doi: 10.1055/a-2174-0963. Online ahead of print.ABSTRACTno abstraact.PMID:37699516 | DOI:10.1055/a-2174-0963
Source: Thrombosis and Haemostasis - September 12, 2023 Category: Hematology Authors: Joseph Caprini MaryAnne Cronin Nancy Dengler Eugene Krauss Source Type: research
Direct comparison and reproducibility of two segmentation methods for multicompartment dosimetry: round robin study on radioembolization treatment planning in hepatocellular carcinoma
CONCLUSION: Anatomic segmentation-based dosimetry, versus 99mTc-MAA segmentation, results in lower absorbed doses with superior reproducibility. Higher volume compartments, such as normal tissue versus tumour, exhibit improved reproducibility.TRIAL REGISTRATION: NCT03295006.PMID:37698645 | DOI:10.1007/s00259-023-06416-9
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Marnix Lam Etienne Garin Xavier Palard-Novello Armeen Mahvash Cheenu Kappadath Paul Haste Mark Tann Ken Herrmann Francesco Barbato Brian Geller Niklaus Schaefer Alban Denys Matthew Dreher Kirk D Fowers Vanessa Gates Riad Salem Source Type: research
Platelet Aggregation is not Altered in Men with Aortic Aneurysms
This study found no higher platelet aggregation or increased frequencies of hyperresponsiveness of platelets in patients with ascending and abdominal aortic dilations.PMID:37699517 | DOI:10.1055/a-2174-0844
Source: Thrombosis and Haemostasis - September 12, 2023 Category: Hematology Authors: Lasse M Obel Jes Sanddal Lindholt Axel Cosmus Pyndt Diederichsen Christian Kring Lars Melholt Rasmussen Anne Alnor Pernille Just Vinholt Source Type: research
A New Chapter Regarding Thrombosis Risk Assessment In Total Joint Replacement Patients
Thromb Haemost. 2023 Sep 12. doi: 10.1055/a-2174-0963. Online ahead of print.ABSTRACTno abstraact.PMID:37699516 | DOI:10.1055/a-2174-0963
Source: Thrombosis and Haemostasis - September 12, 2023 Category: Hematology Authors: Joseph Caprini MaryAnne Cronin Nancy Dengler Eugene Krauss Source Type: research
Direct comparison and reproducibility of two segmentation methods for multicompartment dosimetry: round robin study on radioembolization treatment planning in hepatocellular carcinoma
CONCLUSION: Anatomic segmentation-based dosimetry, versus 99mTc-MAA segmentation, results in lower absorbed doses with superior reproducibility. Higher volume compartments, such as normal tissue versus tumour, exhibit improved reproducibility.TRIAL REGISTRATION: NCT03295006.PMID:37698645 | DOI:10.1007/s00259-023-06416-9
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Marnix Lam Etienne Garin Xavier Palard-Novello Armeen Mahvash Cheenu Kappadath Paul Haste Mark Tann Ken Herrmann Francesco Barbato Brian Geller Niklaus Schaefer Alban Denys Matthew Dreher Kirk D Fowers Vanessa Gates Riad Salem Source Type: research
Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
Life Sci Alliance. 2023 Sep 12;6(11):e202302106. doi: 10.26508/lsa.202302106. Print 2023 Nov.ABSTRACTPreviously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyperinflammation is dependent on high levels of anti-spike IgG with aberrant Fc tail glycosylation, leading to Fcγ receptor hyperactivation. For development of immune-regulatory therapeutics, drug specificity is crucial to counteract excessive inflammation whereas simulta...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Chiara E Geyer Hung-Jen Chen Alexander P Bye Xue D Manz Denise Guerra Tom G Caniels Tom Pl Bijl Guillermo R Griffith Willianne Hoepel Steven W de Taeye Jennifer Veth Alexander Pj Vlaar Amsterdam UMC COVID-19 Biobank Gestur Vidarsson Harm Jan Bogaard Jurja Source Type: research
