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Condition: Thrombosis
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Total 39172 results found since Jan 2013.
Single-Cell RNA Sequencing Reveals Cellular Adaptation of Human Aortic Endothelial Cells to Antiproliferative Therapies Is Modulated by Flow-Induced Shear Stress
CONCLUSIONS: We showed that flow shear stress modulates the cellular capacity of ECs to respond to paclitaxel and rapamycin administration, suggesting that while responding to different flow patterns, ECs experience an impairment in their transcriptional adaptation to other stimuli.PMID:37732484 | DOI:10.1161/ATVBAHA.123.319283
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Antonio G Salazar-Mart Ãn Aditya S Kalluri Martin A Villanueva Travis K Hughes Marc H Wadsworth Ii Tyler T Dao Mercedes Balcells Farhad R Nezami Alex K Shalek Elazer R Edelman Source Type: research
Aging Is Associated With Organ-Specific Alterations in the Level and Expression Pattern of von Willebrand Factor
CONCLUSIONS: Aging elicits a heterogenic response in endothelial cells with regard to VWF expression, leading to organ-specific increase in VWF levels and alterations in vascular tree pattern of expression. This is concomitant with increased platelet aggregate formation. The age-associated increase in VWF expression may be modulated through the process of cell senescence, and p53 transcription factor contributes to its regulation.PMID:37732483 | DOI:10.1161/ATVBAHA.123.319255
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Parnian Alavi Radya Yousef Abdualla Douglas Brown Anahita Mojiri Jayan Nagendran John Lewis Stephane L Bourque Nadia Jahroudi Source Type: research
Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research
Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III
CONCLUSIONS: The benefit of LAA occlusion was consistent whether patients were receiving OACs or not. LAA occlusion provides thromboembolism reduction in patients independent of OAC use.PMID:37732457 | DOI:10.1161/CIRCULATIONAHA.122.060315
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Stuart J Connolly Jeff S Healey Emilie P Belley-Cote Kumar Balasubramanian Domenico Paparella Katheryn Brady Wilko Reents Bernhard C Danner P J Devereaux Mukul Sharma Chinthanie Ramasundarahettige Salim Yusuf Richard P Whitlock Source Type: research
Review-based development of a protocol for intraoperative urokinase in free flap salvage
ConclusionsThere is lack of uniformity in urokinase administration protocols across reconstructive units. We present a step-by step protocol for the use of intraoperative urokinase in free flap salvage that is easy to understand and follow. Standardisation of administration protocol and larger case series are required to determine the true efficacy and utility of urokinase.Level of evidence: Level IV, Therapeutic.
Source: European Journal of Plastic Surgery - September 21, 2023 Category: Cosmetic Surgery Source Type: research
Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc Ãa-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart Ãnez-Alarcón V Ãctor López-López Antonio R Ãos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram Ãrez Pablo Pelegr à Source Type: research
Coagulation management during liver transplantation: monitoring and decision making for hemostatic interventions
Curr Opin Organ Transplant. 2023 Sep 19. doi: 10.1097/MOT.0000000000001101. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Rebalanced hemostasis describes the precarious balance of procoagulant and antithrombotic proteins in patients with severe liver failure. This review is aimed to discuss currently available coagulation monitoring tests and pertinent decision-making process for plasma coagulation factor replacements during liver transplantation (LT).RECENT FINDINGS: Contemporary viscoelastic coagulation monitoring systems have demonstrated advantages over conventional coagulation tests in assessing the patient's coagu...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Kofi B Vandyck Walter Rusin Samhati Mondal Kenichi A Tanaka Source Type: research
General recommendations for the management of glomerular diseases-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):696-704. doi: 10.1007/s00508-023-02265-6. Epub 2023 Sep 20.ABSTRACTGlomerular diseases are associated with extrarenal complications, such as thromboembolism, cardiovascular events and particularly infections. A thorough knowledge of the various immunosuppressants and their associated toxicity profile is therefore of great importance. While nephrologists usually have extensive experience with calcineurin inhibitors and antimetabolites, two other compounds (rituximab, in severe cases cyclophosphamide) are used comparatively infrequently and will be discussed in more detail. Moreove...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Martin Windpessl Philipp Gauckler Emanuel Zitt Karl Lhotta Cihan Ay Kathrin Eller Balazs Odler Irmgard Neumann Michael Rudnicki Andreas Kronbichler Marcus D S äemann Source Type: research
New insight into the traditional model of the coagulation cascade and its regulation: illustrated review of a three-dimensional view
Res Pract Thromb Haemost. 2023 Aug 7;7(6):102160. doi: 10.1016/j.rpth.2023.102160. eCollection 2023 Aug.ABSTRACTThe coagulation process relies on an intricate network of three-dimensional structural interactions and subtle biological regulations. In the present review, we illustrate the state of the art of the structural biology of the coagulation cascade by surveying the Protein Data Bank and the EBI AlphaFold databases. Investigations performed in the last decade have provided structural information on essentially all players involved in the process. Indeed, the initial characterization of specific and rather canonical d...
Source: Thrombosis and Haemostasis - September 20, 2023 Category: Hematology Authors: Romualdo Troisi Nicole Balasco Ida Autiero Filomena Sica Luigi Vitagliano Source Type: research
Effect of therapeutic-dose heparin on severe acute kidney injury and death in noncritically ill patients hospitalized for COVID-19: a prespecified secondary analysis of the ACTIV4a and ATTACC randomized trial
CONCLUSION: Therapeutic-dose heparin was associated with a high probability of superiority to reduce the incidence of in-hospital severe AKI or death in patients hospitalized for COVID-19.PMID:37727846 | PMC:PMC10506136 | DOI:10.1016/j.rpth.2023.102167
Source: Thrombosis and Haemostasis - September 20, 2023 Category: Hematology Authors: Nathaniel R Smilowitz Erinn M Hade Lucy Z Kornblith Lana A Castellucci Mary Cushman Michael Farkouh Michelle N Gong Anna Heath Beverly J Hunt Keri S Kim Andrei Kindzelski Patrick Lawler David E Leaf Ewan Goligher Eric S Leifer Bryan J McVerry Harmony R Re Source Type: research
New insight into the traditional model of the coagulation cascade and its regulation: illustrated review of a three-dimensional view
Res Pract Thromb Haemost. 2023 Aug 7;7(6):102160. doi: 10.1016/j.rpth.2023.102160. eCollection 2023 Aug.ABSTRACTThe coagulation process relies on an intricate network of three-dimensional structural interactions and subtle biological regulations. In the present review, we illustrate the state of the art of the structural biology of the coagulation cascade by surveying the Protein Data Bank and the EBI AlphaFold databases. Investigations performed in the last decade have provided structural information on essentially all players involved in the process. Indeed, the initial characterization of specific and rather canonical d...
Source: Thrombosis and Haemostasis - September 20, 2023 Category: Hematology Authors: Romualdo Troisi Nicole Balasco Ida Autiero Filomena Sica Luigi Vitagliano Source Type: research
Effect of therapeutic-dose heparin on severe acute kidney injury and death in noncritically ill patients hospitalized for COVID-19: a prespecified secondary analysis of the ACTIV4a and ATTACC randomized trial
CONCLUSION: Therapeutic-dose heparin was associated with a high probability of superiority to reduce the incidence of in-hospital severe AKI or death in patients hospitalized for COVID-19.PMID:37727846 | PMC:PMC10506136 | DOI:10.1016/j.rpth.2023.102167
Source: Thrombosis and Haemostasis - September 20, 2023 Category: Hematology Authors: Nathaniel R Smilowitz Erinn M Hade Lucy Z Kornblith Lana A Castellucci Mary Cushman Michael Farkouh Michelle N Gong Anna Heath Beverly J Hunt Keri S Kim Andrei Kindzelski Patrick Lawler David E Leaf Ewan Goligher Eric S Leifer Bryan J McVerry Harmony R Re Source Type: research
Coagulation management during liver transplantation: monitoring and decision making for hemostatic interventions
Curr Opin Organ Transplant. 2023 Sep 19. doi: 10.1097/MOT.0000000000001101. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Rebalanced hemostasis describes the precarious balance of procoagulant and antithrombotic proteins in patients with severe liver failure. This review is aimed to discuss currently available coagulation monitoring tests and pertinent decision-making process for plasma coagulation factor replacements during liver transplantation (LT).RECENT FINDINGS: Contemporary viscoelastic coagulation monitoring systems have demonstrated advantages over conventional coagulation tests in assessing the patient's coagu...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Kofi B Vandyck Walter Rusin Samhati Mondal Kenichi A Tanaka Source Type: research
Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc Ãa-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart Ãnez-Alarcón V Ãctor López-López Antonio R Ãos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram Ãrez Pablo Pelegr à Source Type: research
General recommendations for the management of glomerular diseases-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):696-704. doi: 10.1007/s00508-023-02265-6. Epub 2023 Sep 20.ABSTRACTGlomerular diseases are associated with extrarenal complications, such as thromboembolism, cardiovascular events and particularly infections. A thorough knowledge of the various immunosuppressants and their associated toxicity profile is therefore of great importance. While nephrologists usually have extensive experience with calcineurin inhibitors and antimetabolites, two other compounds (rituximab, in severe cases cyclophosphamide) are used comparatively infrequently and will be discussed in more detail. Moreove...
Source: Hamostaseologie - September 20, 2023 Category: Hematology Authors: Martin Windpessl Philipp Gauckler Emanuel Zitt Karl Lhotta Cihan Ay Kathrin Eller Balazs Odler Irmgard Neumann Michael Rudnicki Andreas Kronbichler Marcus D S äemann Source Type: research
