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Drug: Insulin
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Total 39295 results found since Jan 2013.
Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice
Am J Physiol Cell Physiol. 2023 Sep 11. doi: 10.1152/ajpcell.00232.2023. Online ahead of print.ABSTRACTMyokine Irisin is involved in the regulation of a variety of physiological conditions, metabolism, and survival. We and others have demonstrated that recombinant irisin contributes critically to modulation of insulin resistance and the improvement of cardiac function. However, whether deletion of irisin will regulates cardiac function and insulin sensitivity in type II diabetes remains unclear. We utilized the CRISPR/Cas-9 genome-editing system to delete irisin globally in mice and high fat diet (HFD)-induced type II diab...
Source: Am J Physiol Cell Ph... - September 11, 2023 Category: Cytology Authors: Jianguo Wang Yu Tina Zhao Ling Zhang Patrycja M Dubielecka Gangjian Qin Yueh Eugene Chin Adam C Gower Shougang Zhuang Paul Y Liu Ting C Zhao Source Type: research
Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis
Open Med (Wars). 2023 Aug 30;18(1):20230751. doi: 10.1515/med-2023-0751. eCollection 2023.ABSTRACTThe aim of our study is to disclose the role and underlying molecular mechanisms of circular RNA ubiquitin protein ligase E3 component n-recognin 4 (circ-UBR4) in atherosclerosis (AS). Our data showed that circ-UBR4 expression was upregulated in AS patients and oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cells (VSMCs) compared with healthy volunteer and untreated VSMCs. In addition, ox-LDL stimulated proliferation, migration, and inflammation but decreased apoptosis in VSMCs, which were overturned ...
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Liuliu Feng Tianhua Liu Jun Shi Yu Wang Yuya Yang Wenyin Xiao Yanyan Bai Source Type: research
Hypolipidemic effect of β-caryophyllene in high fat diet and fructose induced type-2 diabetic adult male rats
Bioinformation. 2022 Nov 30;18(11):1087-1091. doi: 10.6026/973206300181087. eCollection 2022.ABSTRACTSkeletal muscle is responsible for the majority of insulin-stimulated whole-body glucose elimination, under normal circumstances. High dietary fat consumption increases stored fat mass and is a major risk factor for metabolic disorders. The conventional pharmacological treatments are associated with many adverse side effects and high rates of secondary failure which lead to an increasing demand for natural products with anti-diabetic activity and lesser side effects. β-Caryophyllene is a naturally occurring sequiterpene th...
Source: Bioinformation - September 11, 2023 Category: Bioinformatics Authors: Vadivel Mani Manikandan Balraj Nithya Rajapandian Chaitra Jinka Shyamaladevi Babu Source Type: research
Effect of β-sitosterol on insulin resistance & amp; protein expression of insulin signalling molecules in quadriceps muscle of high fat diet-induced type-2 diabetic rats
Bioinformation. 2022 Nov 30;18(11):1098-1104. doi: 10.6026/973206300181098. eCollection 2022.ABSTRACTChanges in life style, such as high-calorie diet intake and lack of exercise, have increased the global prevalence of obesity and diabetes. The major pathophysiological event contributing to the development of type 2 diabetes mellitus is the target tissues to insulin action. Currently available drugs are unsuccessful for the treatment of type 2 diabetes due to their unwanted side effects. Hence, search drugs, from plant sources. β-sitosterol is plant sterols with structurally almost like that of cholesterol. It is widely p...
Source: Bioinformation - September 11, 2023 Category: Bioinformatics Authors: Gayathri Sekar Merlin G Madhan Krishnan Shyamaladevi Babu Padmini K Pushpa Konduru Mangai S Source Type: research
Chronic unpredictable mild stress promotes atherosclerosis < em > via < /em > adipose tissue dysfunction in ApoE < sup > -/- < /sup > mice
CONCLUSIONS: These findings indicated that CUMS induces adipose tissue dysfunction via a mechanism that leads to dyslipidemia, increased inflammation, and insulin resistance in the body, thereby exacerbating atherosclerosis. Notably, CUMS that is involved in decreasing the expression of HDL-associated proteins in adipose tissue may be a crucial link between adipose hypertrophy and advanced atherosclerosis. This study reveals a novel mechanism via which CUMS exacerbates atherosclerosis from the novel perspective of abnormal adipose function and identifies a novel potential therapeutic target for this disease.PMID:37692113 |...
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Min Mao Yalan Deng Li Wang Gexin Zhao Ruomei Qi Huan Gong Tao Shen Yitian Xu Deping Liu Beidong Chen Source Type: research
Sodium-Glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy
Curr Drug Targets. 2023 Sep 7. doi: 10.2174/1389450124666230907115831. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes in patients with type 2 diabetes. Previous studies have demonstrated that SGLT2 inhibitors can reduce pathological myocardial hypertrophy with or with...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Zhicheng Gao Jiaqi Bao Yilan Hu Junjie Tu Lifang Ye Lihong Wang Source Type: research
Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL/6N mice
Food Nutr Res. 2023 Aug 23;67. doi: 10.29219/fnr.v67.9413. eCollection 2023.ABSTRACTKaempferia parviflora (KP) rhizome, also called black ginger, has been used as a herbal medicine for many centuries. This current study was aimed at exploring whether KP rhizome extract (KPE) had anti-obesity effects and the mechanism involved. Five-week-old C57BL/6N male mice were allocated into five groups for 8-week feeding with control diet (CD), high-fat diet (HFD), HFD + 150 mg/kg body weight (BW)/day KPE (HFD+K150), HFD + 300 mg/kg BW/day KPE (HFD+K300), and HFD + 600 mg/kg BW/day KPE (HFD+K600). KPE decreased BW, body fat mass, adip...
Source: Food and Nutrition Research - September 11, 2023 Category: Nutrition Authors: Hyun Sook Lee Young Eun Jeon Riyo Awa Susumu Yoshino Eun Ji Kim Source Type: research
A novel berberine derivative targeting adipocyte differentiation to alleviate TNF- α-induced inflammatory effects and insulin resistance in OP9 cells
Biomed Pharmacother. 2023 Sep 9;167:115433. doi: 10.1016/j.biopha.2023.115433. Online ahead of print.ABSTRACTInflammation and insulin resistance play important roles in the development and progression of type 2 diabetes mellitus. The enhancement of adipocyte differentiation can improve insulin sensitivity by increasing glucose uptake, improving insulin signaling, and reducing inflammation. However, only a few adipogenic agents have shown clinical success in patients with type 2 diabetes mellitus. The therapeutic potential of berberine in type 2 diabetes mellitus was confirmed in terms of the target gene-disease relationshi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 11, 2023 Category: Drugs & Pharmacology Authors: Seo Woo Nam Jin Wook Hwang Youn Ho Han Source Type: research
Whole Blood Transcriptomics Identifies Subclasses of Pediatric Septic Shock
Conclusions Two subclasses of pediatric septic shock patients were discovered through genome-wide expression profiling based on whole blood RNA sequencing with major biological and clinical differences. Trial Registration: This is a secondary analysis of data generated as part of the observational CAF PINT ancillary of the HALF PINT study ( NCT01565941). Registered 29 March 2012.PMID:37693502 | PMC:PMC10491329 | DOI:10.21203/rs.3.rs-3267057/v1
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Jamie O Yang Matt S Zinter Matteo Pellegrini Man Yee Wong Kinisha Gala Daniela Markovic Brian Nadel Kerui Peng Nguyen Do Serghei Mangul Vinay M Nadkarni Aaron Karlsberg Dhrithi Deshpande Manish J Butte Lisa Asaro Michael Agus Anil Sapru Source Type: research
IgG and insulin enhance endocytosis in THP-1 cells via activation of phosphatidylinositol 3-kinase (PI3K)
In this study, we investigated the regulatory mechanism of endocytosis in THP-1 cells, a monocytic leukemia cell line. We analyzed the effect of IgG and insulin, which are abundant in the serum and play important roles in immunity and metabolism, respectively, on the endocytic activity in THP-1 cells. The results indicated that IgG and insulin enhance pinocytosis and phagocytosis via activation of phosphatidylinositol 3-kinase (PI3K). Our results suggest that IgG and insulin contribute to the maintenance of endocytic activity and are important for antigen presentation and nutrient uptake.PMID:37696069 | DOI:10.1016/j.bbrc.2023.09.008
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Karin Egusa Shusaku Shibutani Hiroyuki Iwata Source Type: research
Role of lysosomes in insulin signaling and glucose uptake in cultured rat podocytes
Biochem Biophys Res Commun. 2023 Sep 6;679:145-159. doi: 10.1016/j.bbrc.2023.09.012. Online ahead of print.ABSTRACTPodocytes are sensitive to insulin, which governs the functional and structural integrity of podocytes that are essential for proper function of the glomerular filtration barrier. Lysosomes are acidic organelles that are implicated in regulation of the insulin signaling pathway. Cathepsin D (CTPD) and lysosome-associated membrane protein 1 (LAMP1) are major lysosomal proteins that reflect the functional state of lysosomes. However, the effect of insulin on lysosome activity and role of lysosomes in the regulat...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Patrycja Rachubik Dorota Rogacka Irena Audzeyenka Marlena Typiak Magdalena Wysocka Maria Szrejder Adam Lesner Agnieszka Piwkowska Source Type: research
Intense caloric restriction from birth prevents cardiovascular aging in rats
In this study, we investigated in middle-aged rats the consequences of a 50% caloric restriction (CR) from birth on cardiometabolic risk factors, heart function/morphology, ventricular arrhythmia, and fibrillation incidence, and cardiac intracellular proteins involved with redox status and cell survival. From birth to the age of 18 months, rats were divided into an Ad Libitum group (AL18), which had free access to food, and a CR18 group, which had food limited to 50% of that consumed by the AL18. Resting metabolic rate, blood pressure, and heart rate were recorded, and oral glucose and intraperitoneal insulin tolerance tes...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Dirceu de Sousa Melo Liliane Costa-Pereira Carina Sousa Santos Bruno Ferreira Mendes Isaac Konig Bruna Chaves Garcia Ilkilene Queiroz Lauane Gomes Moreno Ricardo Cardoso Cassilhas Elizabethe Adriana Esteves Etel Vieira Rocha Fl ávio Castro Magalhães Luc Source Type: research
IgG and insulin enhance endocytosis in THP-1 cells via activation of phosphatidylinositol 3-kinase (PI3K)
In this study, we investigated the regulatory mechanism of endocytosis in THP-1 cells, a monocytic leukemia cell line. We analyzed the effect of IgG and insulin, which are abundant in the serum and play important roles in immunity and metabolism, respectively, on the endocytic activity in THP-1 cells. The results indicated that IgG and insulin enhance pinocytosis and phagocytosis via activation of phosphatidylinositol 3-kinase (PI3K). Our results suggest that IgG and insulin contribute to the maintenance of endocytic activity and are important for antigen presentation and nutrient uptake.PMID:37696069 | DOI:10.1016/j.bbrc.2023.09.008
Source: Biochemical and Biophysical Research communications - September 11, 2023 Category: Biochemistry Authors: Karin Egusa Shusaku Shibutani Hiroyuki Iwata Source Type: research
Role of lysosomes in insulin signaling and glucose uptake in cultured rat podocytes
Biochem Biophys Res Commun. 2023 Sep 6;679:145-159. doi: 10.1016/j.bbrc.2023.09.012. Online ahead of print.ABSTRACTPodocytes are sensitive to insulin, which governs the functional and structural integrity of podocytes that are essential for proper function of the glomerular filtration barrier. Lysosomes are acidic organelles that are implicated in regulation of the insulin signaling pathway. Cathepsin D (CTPD) and lysosome-associated membrane protein 1 (LAMP1) are major lysosomal proteins that reflect the functional state of lysosomes. However, the effect of insulin on lysosome activity and role of lysosomes in the regulat...
Source: Biochemical and Biophysical Research communications - September 11, 2023 Category: Biochemistry Authors: Patrycja Rachubik Dorota Rogacka Irena Audzeyenka Marlena Typiak Magdalena Wysocka Maria Szrejder Adam Lesner Agnieszka Piwkowska Source Type: research
