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Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies
CONCLUSION: Sarcopenic obesity and hypertension present significant challenges to global public health. Addressing arterial stiffness is paramount in managing these conditions effectively. Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options.PMID:37712242 | DOI:10.4415/ANN_23_03_10
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Mihaela Jurdana Lovro Žiberna Source Type: research
The Association between Circulating Adipocytokine Omentin Levels and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
CONCLUSION: Additional well-designed studies with more sample sizes are essential to clarify the potential role of Omentin as a risk marker of NAFLD.PMID:37711002 | DOI:10.2174/1566524023666230913105910
Source: Current Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Rozita Khodashahi Mohsen Aliakbarian Gordon A Ferns Mohammad-Hassan Arjmand Source Type: research
Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies
CONCLUSION: Sarcopenic obesity and hypertension present significant challenges to global public health. Addressing arterial stiffness is paramount in managing these conditions effectively. Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options.PMID:37712242 | DOI:10.4415/ANN_23_03_10
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Mihaela Jurdana Lovro Žiberna Source Type: research
Development and Characterization of Guinea Pig Anti-Insulin Polyclonal Antibody
Appl Biochem Biotechnol. 2023 Sep 15. doi: 10.1007/s12010-023-04670-z. Online ahead of print.ABSTRACTDevelopment and characterization of guinea pig anti-insulin polyclonal antibody against a target-specific insulin antigen. In India, an insulin immunogenicity kit for detecting insulin antibodies (neutralizing Nab) is an unmet medical need for diabetic patient's routine diagnosis. Type 1 diabetics rely on insulin injections daily basis for survival; if the body develops anti-insulin antibodies and neutralizes the exogenous recombinant insulin, glucose control is lost, and the patient eventually dies. Antibodies are excellen...
Source: Applied Biochemistry and Biotechnology - September 15, 2023 Category: Biochemistry Authors: Sathiya Varadarajan Arumugam Muruganandam V Ramesh Kumar Source Type: research
Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research
Circulating miRNAs detect high versus low visceral adipose tissue inflammation in patients living with obesity
CONCLUSIONS: Circ-miRs that identify patients with low versus high VAT inflammation constitute a putative tool to improve personalized care of patients with obesity.PMID:37713174 | DOI:10.1210/clinem/dgad550
Source: The Journal of Clinical Endocrinology and Metabolism - September 15, 2023 Category: Endocrinology Authors: Nataly Makarenkov Yulia Haim Uri Yoel Yair Pincu Tanya Tarnovscki Idit F Liberty Ivan Kukeev Lior Baraf Oleg Dukhno Oleg Zilber Matthias Bl üher Assaf Rudich Isana Veksler-Lublinsky Source Type: research
Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis
CONCLUSIONS: Apparently healthy individuals without cardiac 18F-FDG uptake have higher HOMA-IR and higher prevalence of MetS traits, cardiovascular risk factors, and early atherosclerosis. An improvement in cardiometabolic profile is associated with the recovery of myocardial 18F-FDG uptake at follow-up.PMID:37713581 | DOI:10.2337/dc23-0871
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Ana Devesa Valentin Fuster Ravi Vazirani In és García-Lunar Bel én Oliva Samuel Espa ña Andrea Moreno-Arciniegas Javier Sanz Cristina Perez-Herreras H éctor Bueno Enrique Lara-Pezzi Ana Garc ía-Alvarez Vicente Mart ínez de Vega Leticia Fern ández- Source Type: research
Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies
CONCLUSION: Sarcopenic obesity and hypertension present significant challenges to global public health. Addressing arterial stiffness is paramount in managing these conditions effectively. Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options.PMID:37712242 | DOI:10.4415/ANN_23_03_10
Source: Ann Ist Super Sanita - September 15, 2023 Category: Biomedical Science Authors: Mihaela Jurdana Lovro Žiberna Source Type: research
Steady solution and its stability of a mathematical model of diabetic atherosclerosis
J Biol Dyn. 2023 Dec;17(1):2257734. doi: 10.1080/17513758.2023.2257734.ABSTRACTAtherosclerosis is a leading cause of death worldwide. Making matters worse, nearly 463 million people have diabetes, which increases atherosclerosis-related inflammation. Diabetic patients are twice as likely to have a heart attack or stroke. In this paper, we consider a simplified mathematical model for diabetic atherosclerosis involving LDL, HDL, glucose, insulin, free radicals (ROS), β cells, macrophages and foam cells, which satisfy a system of partial differential equations with a free boundary, the interface between the blood flow and th...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Xuming Xie Source Type: research
The artificial pancreas: two alternative approaches to achieve a fully closed-loop system with optimal glucose control
CONCLUSION: This narrative review presents two lesser-explored viable solutions for AP systems and discusses the potential for improvement toward a fully automated system: A) using the intraperitoneal approach for more rapid insulin absorption, and B) besides using glucagon to treat and prevent hypoglycemia, also administering micro-boluses of glucagon to increase the local SC blood flow, thereby accelerating SC insulin absorption and SC glucose sensor site dynamics.PMID:37715091 | DOI:10.1007/s40618-023-02193-2
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: M K Åm I A Teigen M Riaz A L Fougner S C Christiansen S M Carlsen Source Type: research
Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation
CONCLUSIONS: Our findings demonstrate that CerS6 deletion improves glucose homeostasis in alcohol-fed mice and exhibits sex-based differences in the attenuation of EtOH-induced weight gain and hepatic steatosis. Additionally, we unveil that CerS6 plays a major role as a regulator of lipid droplet biogenesis in alcohol-induced intra-hepatic lipid droplet formation, identifying it as a putative target for early ALD management.PMID:37714377 | DOI:10.1016/j.molmet.2023.101804
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Sookyoung Jeon Eleonora Scorletti Joseph Dempsey Delfin Buyco Chelsea Lin Yedidya Saiman Susovon Bayen Julia Harkin Jasmin Martin Royce Hooks Besim Ogretmen Josepmaria Argemi Luma Melo Ramon Bataller Rotonya M Carr Source Type: research
Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies
CONCLUSION: Sarcopenic obesity and hypertension present significant challenges to global public health. Addressing arterial stiffness is paramount in managing these conditions effectively. Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options.PMID:37712242 | DOI:10.4415/ANN_23_03_10
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Mihaela Jurdana Lovro Žiberna Source Type: research
The Association between Circulating Adipocytokine Omentin Levels and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
CONCLUSION: Additional well-designed studies with more sample sizes are essential to clarify the potential role of Omentin as a risk marker of NAFLD.PMID:37711002 | DOI:10.2174/1566524023666230913105910
Source: Current Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Rozita Khodashahi Mohsen Aliakbarian Gordon A Ferns Mohammad-Hassan Arjmand Source Type: research
Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research
