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Total 78932 results found since Jan 2013.
FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity
Autophagy. 2023 Sep 18. doi: 10.1080/15548627.2023.2259282. Online ahead of print.ABSTRACTChronic kidney disease (CKD) has reached epidemic proportions worldwide, partly due to the increasing population of elderly and obesity. Macroautophagy/autophagy counteracts CKD progression, whereas autophagy is stagnated owing to lysosomal overburden during aging and obesity, which promotes CKD progression. Therefore, for preventing CKD progression during aging and obesity, it is important to elucidate the compensation mechanisms of autophagy stagnation. We recently showed that FGF21 (fibroblast growth factor 21), which is a prolonge...
Source: Autophagy - September 18, 2023 Category: Cytology Authors: Satoshi Minami Shinsuke Sakai Takeshi Yamamoto Yoshitsugu Takabatake Tomoko Namba-Hamano Atsushi Takahashi Jun Matsuda Hiroaki Yonishi Jun Nakamura Shihomi Maeda Sho Matsui Isao Matsui Yoshitaka Isaka Source Type: research
ATPase-regulated autophagosome biogenesis
Autophagy. 2023 Sep 18:1-2. doi: 10.1080/15548627.2023.2255967. Online ahead of print.ABSTRACTOmega-shaped domains of the endoplasmic reticulum, known as omegasomes, have been suggested to contribute to autophagosome biogenesis, although their exact function is not known. Omegasomes are characterized by the presence of the double FYVE domain containing protein ZFYVE1/DFCP1, but it has remained a paradox that depletion of ZFYVE1 does not prevent bulk macroautophagy/autophagy. We recently showed that ZFYVE1 contains an N-terminal ATPase domain which dimerizes upon ATP binding. Mutations in the ATPase domain that inhibit ATP ...
Source: Autophagy - September 18, 2023 Category: Cytology Authors: Viola N ähse Kay O Schink Harald Stenmark Source Type: research
Spermidine - an old molecule with a new age-defying immune function
Trends Cell Biol. 2023 Sep 16:S0962-8924(23)00166-6. doi: 10.1016/j.tcb.2023.08.002. Online ahead of print.ABSTRACTPolyamines - putrescine, spermidine, and spermine - are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging and cancers. Recent advances in immuno-metabolism and immunotherapy shed new light on the role of spermidine in immune cell regulation and anticancer responses. Here, we review novel works demonstrating that spermidine is prod...
Source: Trends in Cell Biology - September 18, 2023 Category: Cytology Authors: Kenji Chamoto Baihao Zhang Masaki Tajima Tasuku Honjo Sidonia Fagarasan Source Type: research
High-Fat Ketogenic Diets and Ketone Monoester Supplements Differentially Affect Substrate Metabolism during Aerobic Exercise
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00359.2023. Online ahead of print.ABSTRACTChronically adhering to high-fat ketogenic diets or consuming ketone monoester supplements elicits ketosis. Resulting changes in substrate metabolism appear to be drastically different between ketogenic diets and ketone supplements. Consuming a ketogenic diet increases fatty acid oxidation with concomitant decreases in endogenous carbohydrate oxidation. Increased fat oxidation eventually results in an accumulation of circulating ketone bodies, which are metabolites of fatty acids that serve as an alternative source of fue...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Lee M Margolis Stefan M Pasiakos Emily E Howard Source Type: research
Signaling Circuits and the Apical Extracellular Matrix In Aging: Connections Identified in the Nematode < em > Caenorhabditis elegans < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00195.2023. Online ahead of print.ABSTRACTNumerous conserved signaling pathways play critical roles in aging, including insulin, TGF-β, Wnt, and autophagy pathways. Some of these pathways also play prominent roles in the formation and maintenance of the extracellular matrix. The nematode Caenorhabditis elegans has been an enduringly productive system for the identification of conserved mechanisms of biological aging. Recent studies in C. elegans highlight the regulatory circuits between conserved signaling pathways and the extracellular matrix, revealing a bidir...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Hannah Reich Cathy Savage-Dunn Source Type: research
Interleukin-6 and Epidermal Growth Factor as non-invasive biomarkers of progression in chronic glomerulonephritis
The objective of this study was to determine whether the urinary excretion of interleukin-6 (IL-6), transforming growth factor β1 (TGFβ1), monocytes chemoattractant protein (MCP-1), soluble tumor necrosis factor receptor 1 (sTNFR1) and epidermal growth factor (EGF) in patients with newly recognized CGN can serve as prognostic biomarkers in patients with newly recognized CGN and whether they can be effective in predicting a progressive reduction of renal function in prospective observation. The study included 150 Caucasian patients. UIL-6, UTGFβ1, UMCP-1 and UsTNFR1 and UEGF were measured using ELISA methods (Quantikine ...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Ilona Idasiak-Piechocka Mi łosz Miedziaszczyk Aldona Wo źniak El żbieta Pawliczak El żbieta Kaczmarek Andrzej Oko Source Type: research
CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes < em > in vitro < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00291.2023. Online ahead of print.ABSTRACTObesity is a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and the subcutaneous white adipose tissue (scWAT) is the primary lipid storage depot and regulates lipid fluxes to other organs. Our previous work identified genes up-regulated in scWAT of patients with NAFLD: SOCS3, DUSP1, and SIK1. Herein, we knocked down (KD) their expression in human adipose-derived mesenchymal stem cells (hADMSCs) using CRISPR/Cas9 technology and characterized their phenotype. We found that SOCS3, DUSP1, a...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Marta Lopez-Yus Scott Frendo-Cumbo Raquel Del Moral-Bergos Maria Pilar Garcia-Sobreviela Vanesa Bernal-Monterde Mikael Ryd én Silvia Lorente-Cebrian Jose M Arbones-Mainar Source Type: research
Dimethyl fumarate attenuates cholestatic liver injury by activating the NRF2 and FXR pathways and suppressing NLRP3/GSDMD signaling in mice
Exp Cell Res. 2023 Sep 16:113781. doi: 10.1016/j.yexcr.2023.113781. Online ahead of print.ABSTRACTThe progression of cholestasis is characterized by excessive accumulation of bile acids (BAs) in the liver, which leads to oxidative stress (OS), inflammation and liver injury. There are currently limited treatments for cholestasis. Therefore, appropriate drugs for cholestasis treatment need to be developed. Dimethyl fumarate (DMF) has been widely used in the treatment of various diseases and exerts antioxidant and anti-inflammatory effects, but its effect on cholestatic liver disease remains unclarified. We fed mice 3,5-dieth...
Source: Experimental Cell Research - September 18, 2023 Category: Cytology Authors: Ziqian Xu Wan Tang Qiaoling Xie Xinyu Cao Mengni Zhang Xiaoxun Zhang Jin Chai Source Type: research
Corrigendum to Cancer associated fibroblasts-derived exosomes contribute to radioresistance through promoting colorectal cancer stem cells phenotype Exp Cell Res. 2020 Jun 15; 391(2):111956
Exp Cell Res. 2023 Sep 16;432(1):113776. doi: 10.1016/j.yexcr.2023.113776. Online ahead of print.NO ABSTRACTPMID:37722314 | DOI:10.1016/j.yexcr.2023.113776
Source: Experimental Cell Research - September 18, 2023 Category: Cytology Authors: Lei Liu Zhe Zhang Lei Zhou Liya Hu Cun Yin Defeng Qing Shanshan Huang Xiuyu Cai Yuan Chen Source Type: research
Pan-Cancer Analysis of Oncogenic Role of RAD54L and Experimental Validation in Hepatocellular Carcinoma
CONCLUSION: RAD54L exhibits robust expression in both pan-cancer and HCC, exerting a significant influence on the proliferation and migration of HCC cells. These findings highlight its potential as a promising biomarker for pan-cancer and a prospective target for immunotherapy.PMID:37719938 | PMC:PMC10503553 | DOI:10.2147/JIR.S426558
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yongzhen Zhou Chenjie Qiu Qingsheng Fu Tao Li Xudong Zhang Chunfu Zhu Xihu Qin Baoqiang Wu Source Type: research
Acidic environment could modulate the interferon- γ expression: Implication on modulation of cancer and immune cells' interactions
CONCLUSION: Collectively, these results suggest that the acidic microenvironment acted as a key barrier to cancer and immune cells' interactions.PMID:37719323 | PMC:PMC10505064 | DOI:10.2478/abm-2023-0047
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Vishal Sharma Jagdeep Kaur Source Type: research
Using a Modified Delphi Panel to Estimate Health Service Utilization for Patients with Advanced and Non-Advanced Systemic Light Chain Amyloidosis
CONCLUSION: Experts estimated advanced patients, who would not be good candidates for HSCT, would have high rates of hospitalization (traditionally the most expensive type of healthcare utilization) and other health service use. The development of new treatment options that can facilitate organ recovery and improve function may lead to decreased utilization.PMID:37719133 | PMC:PMC10503521 | DOI:10.2147/CEOR.S412079
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Morie Gertz Rafat Abonour Sarah N Gibbs Muriel Finkel Heather Landau Suzanne Lentzsch Grace Lin Anuj Mahindra Tiffany Quock Cara Rosenbaum Michael Rosenzweig Surbhi Sidana Sascha A Tuchman Ronald Witteles Irina Yermilov Michael S Broder Source Type: research
Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer
CONCLUSION: Our research demonstrates a closely relationship among CD47 and the immunological microenvironment of prostate cancer, and blocking CD47 can promote macrophages to phagocytosis of prostate cancer cells. Therefore, CD47 may provide novel strategies for potential immunotherapy of prostate cancer.PMID:37719086 | PMC:PMC10505079 | DOI:10.1155/2023/2473075
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Qianqian Wang Chunxaing Feng Yuchun Chen Tianming Peng Yong Li Kunlin Wu Xiaoyong Pu Hanzhong Chen Jiumin Liu Source Type: research
Extracellular matrix turnover in salivary gland disorders and regenerative therapies: Obstacles and opportunities
J Oral Biol Craniofac Res. 2023 Nov-Dec;13(6):693-703. doi: 10.1016/j.jobcr.2023.08.009. Epub 2023 Sep 12.ABSTRACTSalivary gland (SG) extracellular matrix (ECM) has a major influence on tissue development, homeostasis, and tissue regeneration after injury. During aging, disease, and physical insult, normal remodeling of the SG microenvironment (i.e. ECM) becomes dysregulated, leading to alterations in matrix composition which disrupt tissue architecture/structure, alter cell activity, and negatively impact gland function. Matrix metalloproteinases (MMPs) are a large and diverse family of metalloendopeptidases which play a ...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Milos Marinkovic Olivia N Tran Hanzhou Wang Parveez Abdul-Azees David D Dean Xiao-Dong Chen Chih-Ko Yeh Source Type: research
Rotavirus circumvents the antiviral effects of protein ISGylation via proteasomal degradation of Ube1L
Cell Signal. 2023 Sep 16:110891. doi: 10.1016/j.cellsig.2023.110891. Online ahead of print.ABSTRACTAmong the ramified cellular responses elicited in response to pathogenic stimuli, upregulation and covalent conjugation of an Ubiquitin-like modifier ISG15 to lysine residues of target proteins (ISGylation) through sequential action of three enzymes E1 (Ube1L), E2 (Ube2L6) and E3 (Herc5) have emerged as an important regulatory facet governing innate immunity against numerous viral infections. In the present study, we investigated the interplay between host ISGylation system and Rotavirus (RV). We observed that RV infection up...
Source: Cellular Signalling - September 18, 2023 Category: Cytology Authors: Rakesh Sarkar Upayan Patra Arpita Mukherjee Suvrotoa Mitra Satoshi Komoto Mamta Chawla-Sarkar Source Type: research
