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Specialty: Cytology
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Total 78932 results found since Jan 2013.
Development of lactoferrin-coated multifunctional copolymer micelles to cross the blood-brain barrier
In this study, we prepared and evaluated a novel nano-delivery vehicle system composed of lactoferrin-conjugated (Lf-PIC@Se) micelles. We used a COOH-PEG-PAsp-PV@Se synthesis-based method to prepare the micelles, which involved self-assembly followed by EDC-NHS coupling. Using glutaminyl cyclase inhibitor 8 as a model encapsulated chemical, Lf-PIC@Se micelles achieved a good loading capacity. In vitro analysis demonstrated that Lf-PIC@Se/8 micelles were stable in both neutral and acidic pH solutions in the presence or absence of H2O2, and confirmed their biosafety and compatibility in PC12 and bEND.3 cells. Notably, the ce...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Na Ouyang Chunhua Yang Xia Li Zhenting Zheng Yuanyuan Xu Yinan Wang Wei Xiong Haiqiang Wu Source Type: research
Cell-nanocarrier drug delivery system: a promising strategy for cancer therapy
Drug Deliv Transl Res. 2023 Sep 18. doi: 10.1007/s13346-023-01429-1. Online ahead of print.ABSTRACTTumor targeting has been a great challenge for drug delivery systems. A number of nanotechnology-derived drug carriers have been developed for cancer treatment to improve efficacy and biocompatibility. Among them, the emergence of cell-nanocarriers has attracted great attention, which simulates cell function and has good biocompatibility. They can also escape the clearance of reticuloendothelial system, showing a long-cycle effect. The inherent tumor migration and tumor homing ability of cells increase their significance as t...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Jiefen Yang Xiongxi Shi Yanting Kuang Ruting Wei Lanni Feng Jianming Chen Xin Wu Source Type: research
A new fractional Cattaneo model for enhancing the thermal performance of photovoltaic panels using heat spreader: energy, exergy, economic and enviroeconomic (4E) analysis
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29654-8. Online ahead of print.ABSTRACTA new fractional non-Fourier (Cattaneo) photovoltaic (PV) model is presented to enhance the thermal performance of a PV system combined with a heat spreader (HS). The fractional Cattaneo model is shown to be effective in examining transient processes across the entirety of a PV system, in contrast to the conventional Fourier model's inability to predict system performance. Consequently, a comparison is conducted between the classical Fourier model with the fractional Fourier and fractional Cattaneo models for the PV syst...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Eman F El-Gazar Hamdy Hassan Sherif I Rabia Changhong Hu Waheed K Zahra Source Type: research
Biomonitoring of manganese metal pollution in water and its impacts on biological activities of Biomphalaria alexandrina snail and larvicidal potencies
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29786-x. Online ahead of print.ABSTRACTMetal pollution has many dangerous environmental and human health consequences due to the bioaccumulation in the tissues. The present study aims to measure the bioaccumulation factor of the manganese (Mn) heavy metal in Biomphalaria alexandrina snails' tissues and water samples. The current results showed the concentration of Mn heavy metal in water (87.5 mg/l) and its bioaccumulation factor in Helisoma duryi tissue was higher than that in tissues of Physa acuta and B. alexandrina snails. Results showed that 87.5 mg/l Mn...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Amina Mohamed Ibrahim Ahmed Abdel-Salam Abdel-Haleem Rania Gamal Taha Source Type: research
In vitro spermatogenesis in artificial testis: current knowledge and clinical implications for male infertility
Cell Tissue Res. 2023 Sep 18. doi: 10.1007/s00441-023-03824-z. Online ahead of print.ABSTRACTMen's reproductive health exclusively depends on the appropriate maturation of certain germ cells known as sperm. Certain illnesses, such as Klinefelter syndrome, cryptorchidism, and syndrome of androgen insensitivity or absence of testis maturation in men, resulting in the loss of germ cells and the removal of essential genes on the Y chromosome, can cause non-obstructive azoospermia. According to laboratory research, preserving, proliferating, differentiating, and transplanting spermatogonial stem cells or testicular tissue could...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Zahra Bashiri Mazaher Gholipourmalekabadi Farnaz Khadivi Maryam Salem Azita Afzali Tat-Chuan Cham Morteza Koruji Source Type: research
Identification and characterization of colorectal-cancer-associated SNPs on the SMAD7 locus
CONCLUSION: Our findings reveal a mechanism which underlies the contribution of the fSNP rs8085824 on the SMD7 locus to CRC susceptibility.PMID:37721570 | DOI:10.1007/s00432-023-05402-w
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Zhao Liu Yihan Zhao Hongli Song Huaxue Miao Yingying Wang Chuntian Tu Tianyun Fu Juliang Qin Bing Du Min Qian Hua Ren Source Type: research
Integrating bulk-seq and single-cell-seq reveals disulfidptosis potential index associating with neuroblastoma prognosis and immune infiltration
CONCLUSION: Overall, this study highlights the significance of disulfidptosis as a potential therapeutic target and underscores the importance of integrating immune modulation strategies, offering new avenues for improved management of neuroblastoma.PMID:37721569 | DOI:10.1007/s00432-023-05392-9
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Aiguo Zhu Xin Li Jian Wang Source Type: research
Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis
CONCLUSIONS: Abrogation of lactate-mediated cross-talk between cancer cells and TAM results in durable ADT-independent tumor control in PTEN/p53-deficient AVPC, and warrants further investigation in clinical trials.PMID:37721526 | DOI:10.1158/1078-0432.CCR-23-1441
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Kiranj Chaudagar Hanna M Hieromnimon Anne Kelley Brian Labadie Jordan Shafran Srikrishnan Rameshbabu Catherine Drovetsky Kaela Bynoe Ani Solanki Erica Markiewicz Xiaobing Fan Massimo Loda Akash Patnaik Source Type: research
HER2-selective and reversible tyrosine kinase inhibitor tucatinib potentiates the activity of T-DM1 in preclinical models of HER2-positive breast cancer
Cancer Res Commun. 2023 Sep 11. doi: 10.1158/2767-9764.CRC-23-0302. Online ahead of print.ABSTRACTThe oncogenic receptor HER2 is overexpressed in many cancers, including up to 20% of breast cancers. Despite the availability of HER2-targeted treatments, patients' disease often progresses during therapy, underscoring the need for novel treatment strategies. The addition of tucatinib, a reversible, highly selective HER2 tyrosine kinase inhibitor (TKI), to treatment with trastuzumab and capecitabine significantly improved survival outcomes of patients with HER2-positive metastatic breast cancer, including those with active bra...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Devra Olson Janelle Taylor Kelsi Willis Kelly Hensley Sean Allred Margo Zaval Lauren Farr Robert Thurman Nishi Jain Renee Hein Michelle Ulrich Scott Peterson Anita Kulukian Source Type: research
Pulmonary Invasive Fungal Disease: Ultrasound and Computed Tomography Scan Findings
CONCLUSION: Combining the characteristic findings of ultrasound and CT-scan provides a higher value in diagnosing pulmonary invasive fungal disease.PMID:37721491 | DOI:10.5152/ThoracResPract.2023.23013
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Seyed Ali Alamdaran Raha Bagheri Seyedeh Fatemeh Darvari Elham Bakhtiari Ali Ghasemi Source Type: research
Neo-Darwinian Principles Exemplified in Cancer Genomics
This article covers the insights gained through these extensive studies where neo-Darwinian principles can be inferred to play roles throughout neoplastic transformation. The cells promoted during cancer development exhibit cancer hallmarks combined with the related enabling characteristics as outlined by Hanahan and Weinberg, analogous to natural selection and survival of the fittest. Selection of driver mutations that inactivate proteins encoded by tumor suppressor genes differs in profound ways from mutations that activate tumor promoter proteins. In most cases the later stages of cancer development are characterized by...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Karl E Krueger Source Type: research
Spermidine - an old molecule with a new age-defying immune function
Trends Cell Biol. 2023 Sep 16:S0962-8924(23)00166-6. doi: 10.1016/j.tcb.2023.08.002. Online ahead of print.ABSTRACTPolyamines - putrescine, spermidine, and spermine - are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging and cancers. Recent advances in immuno-metabolism and immunotherapy shed new light on the role of spermidine in immune cell regulation and anticancer responses. Here, we review novel works demonstrating that spermidine is prod...
Source: Trends in Cell Biology - September 18, 2023 Category: Cytology Authors: Kenji Chamoto Baihao Zhang Masaki Tajima Tasuku Honjo Sidonia Fagarasan Source Type: research
Dimethyl fumarate attenuates cholestatic liver injury by activating the NRF2 and FXR pathways and suppressing NLRP3/GSDMD signaling in mice
Exp Cell Res. 2023 Sep 16:113781. doi: 10.1016/j.yexcr.2023.113781. Online ahead of print.ABSTRACTThe progression of cholestasis is characterized by excessive accumulation of bile acids (BAs) in the liver, which leads to oxidative stress (OS), inflammation and liver injury. There are currently limited treatments for cholestasis. Therefore, appropriate drugs for cholestasis treatment need to be developed. Dimethyl fumarate (DMF) has been widely used in the treatment of various diseases and exerts antioxidant and anti-inflammatory effects, but its effect on cholestatic liver disease remains unclarified. We fed mice 3,5-dieth...
Source: Experimental Cell Research - September 18, 2023 Category: Cytology Authors: Ziqian Xu Wan Tang Qiaoling Xie Xinyu Cao Mengni Zhang Xiaoxun Zhang Jin Chai Source Type: research
Corrigendum to Cancer associated fibroblasts-derived exosomes contribute to radioresistance through promoting colorectal cancer stem cells phenotype Exp Cell Res. 2020 Jun 15; 391(2):111956
Exp Cell Res. 2023 Sep 16;432(1):113776. doi: 10.1016/j.yexcr.2023.113776. Online ahead of print.NO ABSTRACTPMID:37722314 | DOI:10.1016/j.yexcr.2023.113776
Source: Experimental Cell Research - September 18, 2023 Category: Cytology Authors: Lei Liu Zhe Zhang Lei Zhou Liya Hu Cun Yin Defeng Qing Shanshan Huang Xiuyu Cai Yuan Chen Source Type: research
Rotavirus circumvents the antiviral effects of protein ISGylation via proteasomal degradation of Ube1L
Cell Signal. 2023 Sep 16:110891. doi: 10.1016/j.cellsig.2023.110891. Online ahead of print.ABSTRACTAmong the ramified cellular responses elicited in response to pathogenic stimuli, upregulation and covalent conjugation of an Ubiquitin-like modifier ISG15 to lysine residues of target proteins (ISGylation) through sequential action of three enzymes E1 (Ube1L), E2 (Ube2L6) and E3 (Herc5) have emerged as an important regulatory facet governing innate immunity against numerous viral infections. In the present study, we investigated the interplay between host ISGylation system and Rotavirus (RV). We observed that RV infection up...
Source: Cellular Signalling - September 18, 2023 Category: Cytology Authors: Rakesh Sarkar Upayan Patra Arpita Mukherjee Suvrotoa Mitra Satoshi Komoto Mamta Chawla-Sarkar Source Type: research
