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Total 182626 results found since Jan 2013.
General recommendations for the management of glomerular diseases-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):696-704. doi: 10.1007/s00508-023-02265-6. Epub 2023 Sep 20.ABSTRACTGlomerular diseases are associated with extrarenal complications, such as thromboembolism, cardiovascular events and particularly infections. A thorough knowledge of the various immunosuppressants and their associated toxicity profile is therefore of great importance. While nephrologists usually have extensive experience with calcineurin inhibitors and antimetabolites, two other compounds (rituximab, in severe cases cyclophosphamide) are used comparatively infrequently and will be discussed in more detail. Moreove...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Martin Windpessl Philipp Gauckler Emanuel Zitt Karl Lhotta Cihan Ay Kathrin Eller Balazs Odler Irmgard Neumann Michael Rudnicki Andreas Kronbichler Marcus D S äemann Source Type: research
Diagnosis and treatment of glomerular diseases with a membranoproliferative glomerulonephritis (MPGN) pattern of injury
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):688-695. doi: 10.1007/s00508-023-02264-7. Epub 2023 Sep 20.ABSTRACTMembranoproliferative glomerulonephritis (MPGN) represents a heterogeneous group of diseases. The common feature of a membranoproliferative lesion pattern in the kidney biopsy can either be idiopathic/primary or-much more frequently-have a secondary cause. The historical classification into MPGN types I to III has largely been abandoned and replaced in recent years by a pathogenesis-oriented classification. A MPGN with C1q, C3 and/or C4 deposits on light microscopy is referred to as immune complex GN (IC-GN), whil...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Michael Rudnicki Martin Windpessl Kathrin Eller Balazs Odler Philipp Gauckler Irmgard Neumann Emanuel Zitt Heinz Regele Andreas Kronbichler Karl Lhotta Marcus D S äemann Source Type: research
Diagnostic and therapy of lupus nephritis - 2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):675-687. doi: 10.1007/s00508-023-02263-8. Epub 2023 Sep 20.ABSTRACTThe manuscript summarizes the consensus of the Austrian Society of Nephrology on the diagnosis and therapy of lupusnephritis, which is built on existing studies and literature. We discuss in detail the immunosuppressive treatment in proliferative forms of lupusnephritis (III and IV ± V) and in pure lupusnephritis V with nephrotic-range proteinuria. Furthermore, the supportive medication in lupusnephritis is summarized in the consensus. The figures were designed to provide the reader a guidance through the therape...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Balazs Odler Marion J Pollheimer Andreas Kronbichler Marcus D S äemann Martin Windpessl Philipp Gauckler Michael Rudnicki Emanuel Zitt Irmgard Neumann Karl Lhotta Kathrin Eller Source Type: research
Diagnosis and therapy of granulomatosis with polyangiitis and microscopic polyangiitis-2023: consensus of the Austrian society of nephrology ( ÖGN) and Austrian society of rheumatology (ÖGR)
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):656-674. doi: 10.1007/s00508-023-02262-9. Epub 2023 Sep 20.ABSTRACTANCA-associated vasculitides (AAV) are rare, complex systemic diseases that are often difficult to diagnose, because of unspecific clinical symptoms at presentation. However, the clinical course may be very dramatic and even life-threatening, necessitating prompt diagnosis and treatment.Therefore, it is important to increase disease awareness among physicians and support colleagues who are not confronted with these rare diseases on a regular basis. Here, the Austrian Society of Nephrology (ÖGN) and the Austrian S...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Balazs Odler Martin Windpessl Kathrin Eller Marcus D S äemann Karl Lhotta Irmgard Neumann Gregor Öberseder Christina Duftner Christian Dejaco Michael Rudnicki Philipp Gauckler Rainer Hintenberger Jochen Zwerina Jens Thiel Andreas Kronbichler Source Type: research
Diagnosis and therapy of membranous nephropathy-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):648-655. doi: 10.1007/s00508-023-02261-w. Epub 2023 Sep 20.ABSTRACTMembranous nephropathy (MN) is an immune-complex glomerulonephritis and is one of the most common causes of nephrotic syndrome in adults and is also one of the autoimmune kidney diseases with the highest rate of spontaneous remission. The most common autoantigen (> 70% of cases) is directed against the phospholipase A2 receptor (PLA2-R) and, with its detection and clinical course, allows for excellent diagnostics as well as optimal therapy monitoring. Other autoantigens are constantly being published and will e...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Marcus D S äemann Balazs Odler Martin Windpessl Heinz Regele Kathrin Eller Irmgard Neumann Michael Rudnicki Philipp Gauckler Andreas Kronbichler Maarten Knechtelsdorfer Source Type: research
Diagnosis and treatment of focal-segmental glomerulosclerosis-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):638-647. doi: 10.1007/s00508-023-02260-x. Epub 2023 Sep 20.ABSTRACTThe histopathological term focal-segmental glomerulosclerosis comprises different pathogenic processes with the unifying features of a high proteinuria and the name-giving glomerular lesion pattern seen on light microscopy. A differentiation according to the underlying cause into primary, secondary and genetic forms is therefore of utmost importance. The pathogenesis of primary focal-segmental glomerulosclerosis remains unknown but, like minimal-change disease, an autoimmune-mediated process leading to podocyte da...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Philipp Gauckler Emanuel Zitt Heinz Regele Kathrin Eller Marcus D S äemann Karl Lhotta Irmgard Neumann Michael Rudnicki Balazs Odler Andreas Kronbichler Johannes Zschocke Martin Windpessl Source Type: research
Diagnosis and treatment of Minimal Change Disease in adults-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):628-637. doi: 10.1007/s00508-023-02258-5. Epub 2023 Sep 20.ABSTRACTMinimal change disease is a glomerulopathy that clinically manifests as acute onset nephrotic syndrome. A diagnosis is made by renal biopsy, implying the absence of glomerular lesions on light microscopy but detection of extensive podocyte foot process effacement on electron miscroscopy. Considering the typically excellent response to immunosuppressive measures (especially to glucocorticoids), an autoimmune pathogenesis is assumed. Although general prognosis is overall beneficial, steroid-dependent, steroid-resist...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Philipp Gauckler Heinz Regele Kathrin Eller Marcus D S äemann Karl Lhotta Emanuel Zitt Irmgard Neumann Michael Rudnicki Balazs Odler Andreas Kronbichler Martin Windpessl Source Type: research
Diagnosis and Treatment of IgA Nephropathy-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):621-627. doi: 10.1007/s00508-023-02257-6. Epub 2023 Sep 20.ABSTRACTImmunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis. It leads to end-stage kidney disease in about a third of the patients within 10 to 20 years. The pathogenesis of IgAN is incompletely understood. It is believed that a dysregulation of the mucosal immune system leads to undergalactosylation of IgA, followed by formation of IgG autoantibodies against undergalactosylated IgA, circulation of these IgG-IgA immune complexes, deposition of the immune complexes in the mesangium, ultimately resulti...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Judith Schimpf Andreas Kronbichler Martin Windpessl Emanuel Zitt Kathrin Eller Marcus D S äemann Karl Lhotta Michael Rudnicki Source Type: research
Consensus recommendations for the diagnosis and therapy of glomerulonephritides of the Austrian Society of Nephrology ( ÖGN) - 2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):619-620. doi: 10.1007/s00508-023-02259-4. Epub 2023 Sep 20.NO ABSTRACTPMID:37728646 | DOI:10.1007/s00508-023-02259-4
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Andreas Kronbichler Marcus D S äemann Source Type: research
Multi-Cancer Early Detection: The New Frontier in Cancer Early Detection
Annu Rev Med. 2023 Sep 20. doi: 10.1146/annurev-med-050522-033624. Online ahead of print.ABSTRACTThe new generation of cancer early detection tests holds remarkable promise for revolutionizing and changing the paradigm of cancer early detection. Dozens of cancer early detection tests are being developed and evaluated. Some are already commercialized and available for use, most as a complement to and not in place of existing recommended cancer screening tests. This review evaluates existing single- and multi-cancer early detection tests (MCEDs), discussing their performance characteristics including sensitivity, specificity...
Source: Annual Review of Medicine - September 20, 2023 Category: General Medicine Authors: Carmen E Guerra Prateek V Sharma Brenda S Castillo Source Type: research
The Evolving Practice of Hospital at Home in the United States
Annu Rev Med. 2023 Sep 20. doi: 10.1146/annurev-med-051022-042210. Online ahead of print.ABSTRACTHospital at Home (HaH) provides hospital-level services in the home to eligible patients who would otherwise require facility-based hospitalization. In the last two decades, studies have shown that HaH can improve patient outcomes and satisfaction and reduce hospital readmissions. Improved technology and greater experience with the model have led to expansion in the scope of patients served and services provided by the model, but dissemination in the United States has been hampered by lack of insurance coverage until recently. ...
Source: Annual Review of Medicine - September 20, 2023 Category: General Medicine Authors: Tuyet-Trinh Truong Albert L Siu Source Type: research
Polypharmacy and Deprescribing in Older Adults
Annu Rev Med. 2023 Sep 20. doi: 10.1146/annurev-med-070822-101947. Online ahead of print.ABSTRACTOlder adults commonly end up on many medications. Deprescribing is an important part of individualizing care for older adults. It is an opportunity to discuss treatment options and revisit medications that may not have been reassessed in many years. A large evidence base exists in the field, suggesting that deprescribing is feasible and safe, though questions remain about the potential clinical benefits. Deprescribing research faces a myriad of challenges, such as identifying and employing the optimal outcome measures. Further,...
Source: Annual Review of Medicine - September 20, 2023 Category: General Medicine Authors: Wade Thompson Emily G McDonald Source Type: research
Ketamine: Mechanisms and Relevance to Treatment of Depression
Annu Rev Med. 2023 Sep 20. doi: 10.1146/annurev-med-051322-120608. Online ahead of print.ABSTRACTMajor depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-based antidepressant drugs are a primary line of treatment for this mental disorder, although the delayed response and incomplete efficacy in some patients highlight the need for improved therapeutic approaches. Over the past two decades, ketamine has shown rapid onset with sustained (up to several days) antidepressant effects in patients whose MDD has not responded to conventional antidepressant drugs. Recent preclinical studies have started ...
Source: Annual Review of Medicine - September 20, 2023 Category: General Medicine Authors: Ji-Woon Kim Kanzo Suzuki Ege T Kavalali Lisa M Monteggia Source Type: research
New Biological Therapies for Multiple Myeloma
This article briefly introduces the clinical features of multiple myeloma and aspects of multiple myeloma biology that modern therapies exploit. Key current and emerging treatment modalities are then reviewed, including cereblon-modulating agents, proteasome inhibitors, monoclonal antibodies, other molecularly targeted therapies (selinexor, venetoclax), chimeric antigen receptor T cells, T cell-engaging bispecific antibodies, and antibody-drug conjugates. For each modality, mechanism of action and clinical considerations are discussed. These therapies are combined and sequenced in modern treatment pathways, discussed at th...
Source: Annual Review of Medicine - September 20, 2023 Category: General Medicine Authors: Alfred L Garfall Source Type: research
