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Therapy: Immunotherapy
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Total 30422 results found since Jan 2013.
Oropharyngeal colostrum immunotherapy and risk reduction of mortality in very low birth weight premature newborns: A clinical trial
CONCLUSION: The OCI proved to be a beneficial intervention, since it reduced the risk of mortality in PTNB with VLBW when compared to the control group.PMID:37690464 | DOI:10.1016/j.jped.2023.07.007
Source: Jornal de Pediatria - September 10, 2023 Category: Pediatrics Authors: Camilla da C Martins Michelle de S X Ramos Amanda O Lyrio Tatiana de O Vieira Simone S da Cruz Graciete O Vieira Source Type: research
The prognostic value of expressions of STAT3, PD-L1, and PD-L2 in Ta/T1 urothelial carcinoma before and after BCG treatment
CONCLUSIONS: The success of BCG treatment in NMIBC was not related to PD-L1, PD-L2, and STAT3 expression status, but PD-L1 expression was correlated with both PD-L2 and STAT3 as well as TILs rate, but this correlation was lost after BCG treatment.PMID:37690934 | DOI:10.1016/j.urolonc.2023.08.012
Source: Urologic Oncology - September 10, 2023 Category: Urology & Nephrology Authors: Aziz Hakk ı Civriz Kerem Teke Enes Malik Akdas Ozdal Dillioglugil Cigdem Vural Busra Yaprak Bayrak Source Type: research
Clinical practice consensus for the diagnosis and management of melanoma in Taiwan
J Formos Med Assoc. 2023 Sep 8:S0929-6646(23)00290-5. doi: 10.1016/j.jfma.2023.07.016. Online ahead of print.ABSTRACTMelanoma is rare in Taiwan. Asian melanoma is distinct from Western melanoma because acral and mucosal melanoma accounts for the majority of melanoma cases, leading to distinct tumor behaviors and genetic profiling. With consideration of the clinical guidelines in Western countries, Taiwanese experts developed a local clinical practice consensus guideline. This consensus includes diagnosis, staging, and surgical and systemic treatment, based only on clinical evidence, local epidemiology, and available resour...
Source: J Formos Med Assoc - September 10, 2023 Category: General Medicine Authors: Chiao-En Wu Yi-Hua Liao Cheng-Lin Wu Ruoh-Fang Yen Chia-Chi Lin Muh-Hwa Yang Chueh-Chuan Yen Wu-Chou Su Chia-Jui Yen Yi-Fang Chang Ming-Fang Wu Youngsen Yang Chen-Yuan Lin Wen-Chi Yang Hui-Ching Wang Cheng-Yuan Li Yin-Yu Ho Yao-Yu Chang Chieh-Shan Wu Hsiu Source Type: research
The prognostic value of expressions of STAT3, PD-L1, and PD-L2 in Ta/T1 urothelial carcinoma before and after BCG treatment
CONCLUSIONS: The success of BCG treatment in NMIBC was not related to PD-L1, PD-L2, and STAT3 expression status, but PD-L1 expression was correlated with both PD-L2 and STAT3 as well as TILs rate, but this correlation was lost after BCG treatment.PMID:37690934 | DOI:10.1016/j.urolonc.2023.08.012
Source: Urologic Oncology - September 10, 2023 Category: Urology & Nephrology Authors: Aziz Hakk ı Civriz Kerem Teke Enes Malik Akdas Ozdal Dillioglugil Cigdem Vural Busra Yaprak Bayrak Source Type: research
Ultra-efficient radio-immunotherapy for reprogramming the hypoxic and immunosuppressive tumor microenvironment with durable innate immune memory
Biomaterials. 2023 Sep 5;302:122303. doi: 10.1016/j.biomaterials.2023.122303. Online ahead of print.ABSTRACTRadiosensitization efficacy of conventional tumor radiosensitizers has been frequently limited by insufficient competence for tumor microenvironment (TME) regulation and unfavorable cellular uptake at biological barriers. Here, we reported an ultra-efficient radiotherapy (RT) strategy by synthesizing an extracellular vesicles (EVs)-encapsulated hollow MnO2 to load metformin (Met@HMnER). It demonstrated significant RT enhancement by morphological control of catalyst and cellular respiratory depression against conventi...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Jichun Yang Chong Zhang Xiaohui Chen Daijun Zhou Zixin Sun Ruyan Niu Ying Zhu Hengyi Chen Liu Wang Yi Chen Yuhan Wang Yunqian Fu Ningyu Ma Jianjun Li Yang Luo Source Type: research
Prognostic value and immunological role of CSNK1D in human cancers
In conclusion, this study suggests that CSNK1D may serve as a biomarker for tumor prognosis and immunotherapy. It influences the proliferation and metastasis of HCC cells.PMID:37688771 | DOI:10.18632/aging.205009
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Jianguo Wang Baohong Hu Weixing Wang Source Type: research
Recurrent Glioblastoma: A Review of the Treatment Options
Cancers (Basel). 2023 Aug 26;15(17):4279. doi: 10.3390/cancers15174279.ABSTRACTGlioblastoma is a disease with a poor prognosis. Multiple efforts have been made to improve the long-term outcome, but the 5-year survival rate is still 5-10%. Recurrence of the disease is the usual way of progression. In this situation, there is no standard treatment. Different treatment options can be considered. Among them would be reoperation or reirradiation. There are different studies that have assessed the impact on survival and the selection of patients who may benefit most from these strategies. Chemotherapy treatments have also been c...
Source: Hand Surgery - September 9, 2023 Category: Surgery Authors: Maria Angeles Vaz-Salgado Mar ía Villamayor V íctor Albarrán V íctor Alía Pilar Sotoca Jes ús Chamorro Diana Rosero Ana M Barrill Mercedes Mart ín Eva Fernandez Jos é Antonio Gutierrez Luis Mariano Rojas-Medina Luis Ley Source Type: research
A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma
Aging (Albany NY). 2023 Sep 8;15. doi: 10.18632/aging.205008. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most common subtype, accounting for about 90% of all primary liver cancers. The liver is rich in a large number of immune cells, thus forming a special immune microenvironment, which plays a key role in the occurrence and development of hepatocellular carcinoma. Nowadays, tumor immunotherapy has become one of the most promising cancer treatment methods. Immune checkpoint inhibitors (ICIs) combined with VEGF inhibitors are listed as first-line treatment options for advanced HCC. Therefore, the se...
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Tianyu Wang Kang Xia Tao Qiu Shangting Han Zhongbao Chen Xiaoxiong Ma Long Zhang Jilin Zou Yalong Zhang Bo Yu Chenyang Kong Jiayu Guo Yiting Liu Jiangqiao Zhou Shusen Zheng Source Type: research
TIMP1 shapes an immunosuppressive microenvironment by regulating anoikis to promote the progression of clear cell renal cell carcinoma
CONCLUSIONS: ARGs played crucial roles in tumorigenesis and progression and were positively associated with a poor prognosis. AI had great accuracy in predicting the prognosis and immune characteristics of ccRCC patients. TIMP1 was significantly associated with clinicopathological variables and the immunosuppressive microenvironment, which could be exploited to design novel immunotherapies for ccRCC patients.PMID:37688768 | DOI:10.18632/aging.205005
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Qiang Li Kai Wei Xi Zhang Yang Lv Miao Li Chenchao Zhou Shifeng Su Daorong Hou Jianquan Hou Source Type: research
Prognostic value and immunological role of CSNK1D in human cancers
In conclusion, this study suggests that CSNK1D may serve as a biomarker for tumor prognosis and immunotherapy. It influences the proliferation and metastasis of HCC cells.PMID:37688771 | DOI:10.18632/aging.205009
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Jianguo Wang Baohong Hu Weixing Wang Source Type: research
A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma
Aging (Albany NY). 2023 Sep 8;15. doi: 10.18632/aging.205008. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most common subtype, accounting for about 90% of all primary liver cancers. The liver is rich in a large number of immune cells, thus forming a special immune microenvironment, which plays a key role in the occurrence and development of hepatocellular carcinoma. Nowadays, tumor immunotherapy has become one of the most promising cancer treatment methods. Immune checkpoint inhibitors (ICIs) combined with VEGF inhibitors are listed as first-line treatment options for advanced HCC. Therefore, the se...
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Tianyu Wang Kang Xia Tao Qiu Shangting Han Zhongbao Chen Xiaoxiong Ma Long Zhang Jilin Zou Yalong Zhang Bo Yu Chenyang Kong Jiayu Guo Yiting Liu Jiangqiao Zhou Shusen Zheng Source Type: research
TIMP1 shapes an immunosuppressive microenvironment by regulating anoikis to promote the progression of clear cell renal cell carcinoma
CONCLUSIONS: ARGs played crucial roles in tumorigenesis and progression and were positively associated with a poor prognosis. AI had great accuracy in predicting the prognosis and immune characteristics of ccRCC patients. TIMP1 was significantly associated with clinicopathological variables and the immunosuppressive microenvironment, which could be exploited to design novel immunotherapies for ccRCC patients.PMID:37688768 | DOI:10.18632/aging.205005
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Qiang Li Kai Wei Xi Zhang Yang Lv Miao Li Chenchao Zhou Shifeng Su Daorong Hou Jianquan Hou Source Type: research
Anti-NMDAR encephalitis secondary to acute necrotizing encephalopathy caused by herpes simplex virus infection in infants: Case series
CONCLUSION: Infants with ANE associated with HSV can develop secondary anti-NMDAR encephalitis, recognition of which is critical to ensure the appropriate institution of immunotherapy after active CNS infection has been ruled out.PMID:37689014 | DOI:10.1016/j.clineuro.2023.107955
Source: Herpes - September 9, 2023 Category: Infectious Diseases Authors: Jia Zhang Jinfeng Liu Jianjun Wang Jing Gan Source Type: research
Ultra-efficient radio-immunotherapy for reprogramming the hypoxic and immunosuppressive tumor microenvironment with durable innate immune memory
Biomaterials. 2023 Sep 5;302:122303. doi: 10.1016/j.biomaterials.2023.122303. Online ahead of print.ABSTRACTRadiosensitization efficacy of conventional tumor radiosensitizers has been frequently limited by insufficient competence for tumor microenvironment (TME) regulation and unfavorable cellular uptake at biological barriers. Here, we reported an ultra-efficient radiotherapy (RT) strategy by synthesizing an extracellular vesicles (EVs)-encapsulated hollow MnO2 to load metformin (Met@HMnER). It demonstrated significant RT enhancement by morphological control of catalyst and cellular respiratory depression against conventi...
Source: Biomaterials - September 9, 2023 Category: Materials Science Authors: Jichun Yang Chong Zhang Xiaohui Chen Daijun Zhou Zixin Sun Ruyan Niu Ying Zhu Hengyi Chen Liu Wang Yi Chen Yuhan Wang Yunqian Fu Ningyu Ma Jianjun Li Yang Luo Source Type: research
