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Potential Interaction between Sodium Polystyrene Sulfonate and Prescription Drugs in Artificial Intestinal Juice
This study evaluated the interaction between sodium polystyrene sulfonate (SPS) and several commonly used concomitant drugs, such as carvedilol, bisoprolol, imidapril, atorvastatin and azilsartan. The residual rate of adsorption 6 h after starting the experiment followed the order carvedilol (0.36%) < bisoprolol (19.7%) < imidapril (81.2%) < atorvastatin (86.5%) < azilsartan (87.9%) in artificial intestinal juice (pH 6.8). In addition, the pKa of carvedilol and bisoprolol was 8.0 and 9.6 and that of atorvastatin, azilsartan, and imidapril was 4.5, 6.1, and 2.4, respectively. These results indicate that the form...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yuri Mizuno Yugo Uematsu Kyohei Nishida Fumihiko Ogata Naohito Kawasaki Source Type: research

Evidence-Based Cardiovascular Disease Medicines' Availability in Low-Cost Generic Drug Programs in the United States : A Cross-Sectional Study
CONCLUSION: Coverage of evidence-based medications for the 6 CVDs investigated varied by LCGP and condition. Because high availability of core CVD pharmacotherapy can enhance optimal disease state management, LCGPs should identify existing limitations in their coverage and continuously revise their formularies to improve the comprehensiveness of CVD medication coverage.PRIMARY FUNDING SOURCE: None.PMID:37665997 | DOI:10.7326/M23-0287
Source: Annals of Internal Medicine - September 4, 2023 Category: Internal Medicine Authors: Ivy T Ton Jungyeon Moon Anthony Sengul Freny Vaghaiwalla Mody Towhid Rahman Janet K Han Cynthia A Jackevicius Source Type: research

Effect of a Family Pharmacist System on Medication Adherence of Patients with Dyslipidemia during a COVID-19 Epidemic
In this study, using anonymously processed receipt data from 700 insurance pharmacies in our group, we evaluated medication adherence in patients taking statin drugs before, during the first and second years of coronavirus disease 2019 (COVID-19) epidemic in terms of medication persistence and medication possession, and compared the results between the family pharmacist group (FP group) and non-family pharmacist group (NoFP group). The odds ratios of good medication adherence (medication persistence and medication possession) rates for the FP group relative to the NoFP group were 1.446 [95% confidence interval (CI): 1.210-...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Mamoru Maeda Yoshitaka Hasegawa Ryota Tsukioka Miya Oishi Source Type: research

Potential Interaction between Sodium Polystyrene Sulfonate and Prescription Drugs in Artificial Intestinal Juice
This study evaluated the interaction between sodium polystyrene sulfonate (SPS) and several commonly used concomitant drugs, such as carvedilol, bisoprolol, imidapril, atorvastatin and azilsartan. The residual rate of adsorption 6 h after starting the experiment followed the order carvedilol (0.36%) < bisoprolol (19.7%) < imidapril (81.2%) < atorvastatin (86.5%) < azilsartan (87.9%) in artificial intestinal juice (pH 6.8). In addition, the pKa of carvedilol and bisoprolol was 8.0 and 9.6 and that of atorvastatin, azilsartan, and imidapril was 4.5, 6.1, and 2.4, respectively. These results indicate that the form...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yuri Mizuno Yugo Uematsu Kyohei Nishida Fumihiko Ogata Naohito Kawasaki Source Type: research

Evidence-Based Cardiovascular Disease Medicines' Availability in Low-Cost Generic Drug Programs in the United States : A Cross-Sectional Study
CONCLUSION: Coverage of evidence-based medications for the 6 CVDs investigated varied by LCGP and condition. Because high availability of core CVD pharmacotherapy can enhance optimal disease state management, LCGPs should identify existing limitations in their coverage and continuously revise their formularies to improve the comprehensiveness of CVD medication coverage.PRIMARY FUNDING SOURCE: None.PMID:37665997 | DOI:10.7326/M23-0287
Source: Annals of Internal Medicine - September 4, 2023 Category: Internal Medicine Authors: Ivy T Ton Jungyeon Moon Anthony Sengul Freny Vaghaiwalla Mody Towhid Rahman Janet K Han Cynthia A Jackevicius Source Type: research

Effect of a Family Pharmacist System on Medication Adherence of Patients with Dyslipidemia during a COVID-19 Epidemic
In this study, using anonymously processed receipt data from 700 insurance pharmacies in our group, we evaluated medication adherence in patients taking statin drugs before, during the first and second years of coronavirus disease 2019 (COVID-19) epidemic in terms of medication persistence and medication possession, and compared the results between the family pharmacist group (FP group) and non-family pharmacist group (NoFP group). The odds ratios of good medication adherence (medication persistence and medication possession) rates for the FP group relative to the NoFP group were 1.446 [95% confidence interval (CI): 1.210-...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Mamoru Maeda Yoshitaka Hasegawa Ryota Tsukioka Miya Oishi Source Type: research

Evidence-Based Cardiovascular Disease Medicines' Availability in Low-Cost Generic Drug Programs in the United States : A Cross-Sectional Study
CONCLUSION: Coverage of evidence-based medications for the 6 CVDs investigated varied by LCGP and condition. Because high availability of core CVD pharmacotherapy can enhance optimal disease state management, LCGPs should identify existing limitations in their coverage and continuously revise their formularies to improve the comprehensiveness of CVD medication coverage.PRIMARY FUNDING SOURCE: None.PMID:37665997 | DOI:10.7326/M23-0287
Source: Annals of Internal Medicine - September 4, 2023 Category: Internal Medicine Authors: Ivy T Ton Jungyeon Moon Anthony Sengul Freny Vaghaiwalla Mody Towhid Rahman Janet K Han Cynthia A Jackevicius Source Type: research

Potential Interaction between Sodium Polystyrene Sulfonate and Prescription Drugs in Artificial Intestinal Juice
This study evaluated the interaction between sodium polystyrene sulfonate (SPS) and several commonly used concomitant drugs, such as carvedilol, bisoprolol, imidapril, atorvastatin and azilsartan. The residual rate of adsorption 6 h after starting the experiment followed the order carvedilol (0.36%) < bisoprolol (19.7%) < imidapril (81.2%) < atorvastatin (86.5%) < azilsartan (87.9%) in artificial intestinal juice (pH 6.8). In addition, the pKa of carvedilol and bisoprolol was 8.0 and 9.6 and that of atorvastatin, azilsartan, and imidapril was 4.5, 6.1, and 2.4, respectively. These results indicate that the form...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yuri Mizuno Yugo Uematsu Kyohei Nishida Fumihiko Ogata Naohito Kawasaki Source Type: research

Evidence-Based Cardiovascular Disease Medicines' Availability in Low-Cost Generic Drug Programs in the United States : A Cross-Sectional Study
CONCLUSION: Coverage of evidence-based medications for the 6 CVDs investigated varied by LCGP and condition. Because high availability of core CVD pharmacotherapy can enhance optimal disease state management, LCGPs should identify existing limitations in their coverage and continuously revise their formularies to improve the comprehensiveness of CVD medication coverage.PRIMARY FUNDING SOURCE: None.PMID:37665997 | DOI:10.7326/M23-0287
Source: Annals of Internal Medicine - September 4, 2023 Category: Internal Medicine Authors: Ivy T Ton Jungyeon Moon Anthony Sengul Freny Vaghaiwalla Mody Towhid Rahman Janet K Han Cynthia A Jackevicius Source Type: research

Effect of a Family Pharmacist System on Medication Adherence of Patients with Dyslipidemia during a COVID-19 Epidemic
In this study, using anonymously processed receipt data from 700 insurance pharmacies in our group, we evaluated medication adherence in patients taking statin drugs before, during the first and second years of coronavirus disease 2019 (COVID-19) epidemic in terms of medication persistence and medication possession, and compared the results between the family pharmacist group (FP group) and non-family pharmacist group (NoFP group). The odds ratios of good medication adherence (medication persistence and medication possession) rates for the FP group relative to the NoFP group were 1.446 [95% confidence interval (CI): 1.210-...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Mamoru Maeda Yoshitaka Hasegawa Ryota Tsukioka Miya Oishi Source Type: research

Potential Interaction between Sodium Polystyrene Sulfonate and Prescription Drugs in Artificial Intestinal Juice
This study evaluated the interaction between sodium polystyrene sulfonate (SPS) and several commonly used concomitant drugs, such as carvedilol, bisoprolol, imidapril, atorvastatin and azilsartan. The residual rate of adsorption 6 h after starting the experiment followed the order carvedilol (0.36%) < bisoprolol (19.7%) < imidapril (81.2%) < atorvastatin (86.5%) < azilsartan (87.9%) in artificial intestinal juice (pH 6.8). In addition, the pKa of carvedilol and bisoprolol was 8.0 and 9.6 and that of atorvastatin, azilsartan, and imidapril was 4.5, 6.1, and 2.4, respectively. These results indicate that the form...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yuri Mizuno Yugo Uematsu Kyohei Nishida Fumihiko Ogata Naohito Kawasaki Source Type: research

Effect of a Family Pharmacist System on Medication Adherence of Patients with Dyslipidemia during a COVID-19 Epidemic
In this study, using anonymously processed receipt data from 700 insurance pharmacies in our group, we evaluated medication adherence in patients taking statin drugs before, during the first and second years of coronavirus disease 2019 (COVID-19) epidemic in terms of medication persistence and medication possession, and compared the results between the family pharmacist group (FP group) and non-family pharmacist group (NoFP group). The odds ratios of good medication adherence (medication persistence and medication possession) rates for the FP group relative to the NoFP group were 1.446 [95% confidence interval (CI): 1.210-...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Mamoru Maeda Yoshitaka Hasegawa Ryota Tsukioka Miya Oishi Source Type: research