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Therapy: Stem Cell Therapy
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Total 56269 results found since Jan 2013.
The repair and regeneration mechanism of platelet-rich fibrin-promoting tissue after alveolar bone defect through the notch pathway
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):85-90. doi: 10.14715/cmb/2023.69.7.14.ABSTRACTThis work investigated the effects of platelet-rich fibrin (PRF) combined with bone mesenchymal stem cells (BMSCs) on the repair of alveolar bone defect (ABD) and the related mechanism of the Notch1/Wnt3a signaling pathway. 28 healthy male New Zealand white rabbits were selected to prepare the BMSCs and PRF. Rabbits were rolled into a combination group (implanted with PRF + BMSCs for treatment), a PRF group (treated with PRF) a BMSC group (BMSCs for treatment), and a control group (Ctrl group, no material implantation), with 7 r...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Tao Li Hui Long Wei Niu Bo Feng Source Type: research
Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):84-88. doi: 10.14715/cmb/2023.69.8.13.ABSTRACTTo investigate the inhibitory mechanism of the KIF3A gene on nasopharyngeal carcinoma (NPC) tumor stem cells. Set up a blank control group (BCG), NPC group, and KIF3A silence (si-KIF3A) group. The BCG cells were nasopharyngeal normal epithelial cell line NP69, without any treatment, and were cultured routinely; The NPC group cells are human NPC cell line CNE2 cells, which are not subjected to any treatment and are cultured routinely; si-KIF3A group cells were cultured in the offspring of human NPC cell line CNE2 infected with Le...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Rongrong Liu Te Li Weitao Zhang Source Type: research
Human muscle cells sensitivity to chikungunya virus infection relies on their glycolysis activity and differentiation stage
Biochimie. 2023 Sep 14:S0300-9084(23)00214-6. doi: 10.1016/j.biochi.2023.09.005. Online ahead of print.ABSTRACTChanges to our environment have led to the emergence of human pathogens such as chikungunya virus. Chikungunya virus infection is today a major public health concern. It is a debilitating chronic disease impeding patients' mobility, affecting millions of people. Disease development relies on skeletal muscle infection. The importance of skeletal muscle in chikungunya virus infection led to the hypothesis that it could serve as a viral reservoir and could participate to virus persistence. Here we questioned the inte...
Source: Biochimie - September 16, 2023 Category: Biochemistry Authors: M Jaquet M Bengue K Lambert G Carnac D Miss é C Bisbal Source Type: research
Enhancing differentiation of menstrual blood-derived stem cells into female germ cells using a bilayer amniotic membrane and nano-fibrous fibroin scaffold
This study aims to investigate the influence of a bilayer amniochorionic membrane/nanofibrous fibroin scaffold on the differentiation of human menstrual blood mesenchymal stromal/stem cells (MenSCs) into female germ cells. MenSCs were isolated and assigned to four culture groups: (i) MenSCs co-cultured with granulosa cells (GCs) using the scaffold (3D-T group), (ii) MenSCs using the scaffold alone (3D-C group), (iii) MenSCs co-cultured only with GCs (2D-T group), and (iv) MenSCs without co-culture or scaffold (2D-C group). Both MenSCs and GCs were independently cultured for two weeks before co-culturing was initiated. Flow...
Source: Tissue and Cell - September 16, 2023 Category: Cytology Authors: Safoura Izanlou Alireza Afshar Afshin Zare Kulyash R Zhilisbayeva Shabnam Bakhshalizadeh Zahra Safaei Soheila Sehat-Bakhsh Sajed Khaledi Hamid-Reza Asgari Somaieh Kazemnejad Mansoureh Ajami Monireh Ajami Masoumeh Dehghan Tarzjani Vahid Najafzadeh Mohammad Source Type: research
Exosomes derived from human umbilical cord mesenchymal stem cells loaded with RVG-Lamp2b and Netrin-1 promotes Schwann cell invasion and migration
CONCLUSION: HucMSC-derived exosomes loaded with RVG-Lamp2b and Netrin-1 promote proliferation, migration, and invasion of Schwann cells.PMID:37716176 | DOI:10.1016/j.tice.2023.102219
Source: Tissue and Cell - September 16, 2023 Category: Cytology Authors: Jie He Zhongju Du Hua Zhang Bo Wang Jurong Xia Source Type: research
Enhancing differentiation of menstrual blood-derived stem cells into female germ cells using a bilayer amniotic membrane and nano-fibrous fibroin scaffold
This study aims to investigate the influence of a bilayer amniochorionic membrane/nanofibrous fibroin scaffold on the differentiation of human menstrual blood mesenchymal stromal/stem cells (MenSCs) into female germ cells. MenSCs were isolated and assigned to four culture groups: (i) MenSCs co-cultured with granulosa cells (GCs) using the scaffold (3D-T group), (ii) MenSCs using the scaffold alone (3D-C group), (iii) MenSCs co-cultured only with GCs (2D-T group), and (iv) MenSCs without co-culture or scaffold (2D-C group). Both MenSCs and GCs were independently cultured for two weeks before co-culturing was initiated. Flow...
Source: Tissue and Cell - September 16, 2023 Category: Cytology Authors: Safoura Izanlou Alireza Afshar Afshin Zare Kulyash R Zhilisbayeva Shabnam Bakhshalizadeh Zahra Safaei Soheila Sehat-Bakhsh Sajed Khaledi Hamid-Reza Asgari Somaieh Kazemnejad Mansoureh Ajami Monireh Ajami Masoumeh Dehghan Tarzjani Vahid Najafzadeh Mohammad Source Type: research
Exosomes derived from human umbilical cord mesenchymal stem cells loaded with RVG-Lamp2b and Netrin-1 promotes Schwann cell invasion and migration
CONCLUSION: HucMSC-derived exosomes loaded with RVG-Lamp2b and Netrin-1 promote proliferation, migration, and invasion of Schwann cells.PMID:37716176 | DOI:10.1016/j.tice.2023.102219
Source: Tissue and Cell - September 16, 2023 Category: Cytology Authors: Jie He Zhongju Du Hua Zhang Bo Wang Jurong Xia Source Type: research
Salmonella inhibits tumor metastasis by downregulating epithelial cell adhesion molecules through the protein kinase-B/mammalian target of rapamycin signaling pathway
Int J Biol Macromol. 2023 Sep 14:126913. doi: 10.1016/j.ijbiomac.2023.126913. Online ahead of print.ABSTRACTEpithelial cell adhesion molecules (EpCAM) are highly expressed in many carcinomas and regulate the epithelial-mesenchymal transition, which is required for tumor metastasis. Furthermore, EpCAM overexpression induces tumor cells to develop a stem cell-like phenotype and promotes tumor progression. Targeting EpCAM may be a promising approach for inhibiting tumor metastasis and progression. Salmonella treatment suppresses tumor growth and reduces metastatic nodules in tumor-bearing mice. Based on these results, we hypo...
Source: International Journal of Biological Macromolecules - September 16, 2023 Category: Biochemistry Authors: Wei-Che Yen Qiao-Zhu Li Li-Hsien Wu Wei-Ya Lee Wen-Wei Chang Peng-Ju Chien Che-Hsin Lee Source Type: research
Human muscle cells sensitivity to chikungunya virus infection relies on their glycolysis activity and differentiation stage
Biochimie. 2023 Sep 14:S0300-9084(23)00214-6. doi: 10.1016/j.biochi.2023.09.005. Online ahead of print.ABSTRACTChanges to our environment have led to the emergence of human pathogens such as chikungunya virus. Chikungunya virus infection is today a major public health concern. It is a debilitating chronic disease impeding patients' mobility, affecting millions of people. Disease development relies on skeletal muscle infection. The importance of skeletal muscle in chikungunya virus infection led to the hypothesis that it could serve as a viral reservoir and could participate to virus persistence. Here we questioned the inte...
Source: Biochimie - September 16, 2023 Category: Biochemistry Authors: M Jaquet M Bengue K Lambert G Carnac D Miss é C Bisbal Source Type: research
Current progress in engineered and nano-engineered mesenchymal stem cells for cancer: From mechanisms to therapy
Biomed Pharmacother. 2023 Sep 14;167:115505. doi: 10.1016/j.biopha.2023.115505. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs), as self-renewing multipotent stromal cells, have been considered promising agents for cancer treatment. A large number of studies have demonstrated the valuable properties of MSC-based treatment, such as low immunogenicity and intrinsic tumor-trophic migratory properties. To enhance the potency of MSCs for therapeutic purposes, equipping MSCs with targeted delivery functions using genetic engineering is highly beneficial. Genetically engineered MSCs can express tumor suppressor agents...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Forough Shams Bahareh Pourjabbar Nader Hashemi Navid Farahmandian Ali Golchin Ghader Nuoroozi Azam Rahimpour Source Type: research
Ciltacabtagene Autoleucel in Patients With Prior Allogeneic Stem Cell Transplant in the CARTITUDE-1 Study
CONCLUSION: Cilta-cel efficacy and safety were comparable between CARTITUDE-1 patients with and without prior alloSCT. Additional studies are needed to fully elucidate the suitability of CAR-T cell therapy in the post-alloSCT setting.PMID:37716872 | DOI:10.1016/j.clml.2023.08.012
Source: Clinical Lymphoma and Myeloma - September 16, 2023 Category: Cancer & Oncology Authors: Myo Htut Binod Dhakal Adam D Cohen Thomas Martin Jesus G Berdeja Saad Z Usmani Mounzer Agha Carolyn C Jackson Deepu Madduri William Deraedt Enrique Zudaire Tzu-Min Yeh Xiaoying Xu Lida Pacaud Muhammad Akram Sundar Jagannath Source Type: research
Current progress in engineered and nano-engineered mesenchymal stem cells for cancer: From mechanisms to therapy
Biomed Pharmacother. 2023 Sep 14;167:115505. doi: 10.1016/j.biopha.2023.115505. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs), as self-renewing multipotent stromal cells, have been considered promising agents for cancer treatment. A large number of studies have demonstrated the valuable properties of MSC-based treatment, such as low immunogenicity and intrinsic tumor-trophic migratory properties. To enhance the potency of MSCs for therapeutic purposes, equipping MSCs with targeted delivery functions using genetic engineering is highly beneficial. Genetically engineered MSCs can express tumor suppressor agents...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Forough Shams Bahareh Pourjabbar Nader Hashemi Navid Farahmandian Ali Golchin Ghader Nuoroozi Azam Rahimpour Source Type: research
