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Vaccination: Malaria Vaccine
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Total 1540 results found since Jan 2013.
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 | DOI:10.31952/amha.21.1.4
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles
Recent studies have suggested that CD8+ liver-resident memory T (TRM) cells are crucial in the protection against liver-stage malaria. We used liver-directed mRNA-containing lipid nanoparticles (mRNA-LNPs) to induce liver TRM cells in a murine model. Single-dose intravenous injections of ovalbumin mRNA-LNPs effectively induced antigen-specific cytotoxic T lymphocytes in a dose-dependent manner in the liver on day 7. TRM cells (CD8+ CD44hi CD62Llo CD69+ KLRG1-) were induced 5 weeks after immunization. To examine the protective efficacy, mice were intramuscularly immunized with two doses of circumsporozoite protein mRNA-LNPs...
Source: Frontiers in Immunology - August 23, 2023 Category: Allergy & Immunology Source Type: research
Protein Conjugated Superparamagnetic Iron Oxide Nanoparticles for Efficient Vaccine Delivery Systems
AbstractA novel class of nanomaterials as subunit nano vaccines has shown great potential for delivering antigens to the target in a safe and effective manner. Herein, functionalized superparamagnetic iron oxide nanoparticle (SPION) surfaces with conjugated a malaria protein (vaccine) and carboxyl groups have a comparatively high capacity to bind protein. SPIONs were synthesized using the chemical coprecipitation process, then coated with either 3-aminopropyltriethoxysilane or with PEG plus APTS and characterized using DSL-zeta potential, VSM, TG and SEM. Furthermore, SDS-PAGE was used to measure the amount of protein spec...
Source: Plasmonics - August 17, 2023 Category: Biomedical Science Source Type: research
Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria
Expert Rev Vaccines. 2023 Aug 11. doi: 10.1080/14760584.2023.2245890. Online ahead of print.ABSTRACTINTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite.AREAS COVERED: Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine immunogen achieving > 90% efficacy against Pf infection. This review describes &g...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Thomas L Richie L W Preston Church Tooba Murshedkar Peter F Billingsley Eric R James Mei-Chun Chen Yonas Abebe None Natasha Kc Sumana Chakravarty David Dolberg Sara A Healy Halimatou Diawara Mahamadou S Sissoko Issaka Sagara David M Cook Judith E Epstein Source Type: research
Preliminary studies on the immunogenicity of a prime-and-trap malaria vaccine in nonhuman primates
Vaccine. 2023 Aug 8:S0264-410X(23)00913-1. doi: 10.1016/j.vaccine.2023.07.067. Online ahead of print.ABSTRACTDevelopment of next-generation vaccines against Plasmodium falciparum (Pf) is a priority. Many malaria vaccines target the pre-erythrocytic sporozoite (SPZ) and liver stages. These include subunit vaccines based on the Pf circumsporozoite protein (CSP) and attenuated PfSPZ vaccines. However, these strategies require 3-4 doses and have not achieved optimal efficacy against field-transmitted malaria. Prime-and-trap is a recently developed two-step heterologous vaccine strategy that combines priming with DNA encoding C...
Source: Vaccine - August 10, 2023 Category: Allergy & Immunology Authors: Melanie J Shears Felicia N Watson Brad C Stone Irene Cruz Talavera Chaitra Parthiban Jokichi Matsubara Natasha Kc B Kim Lee Sim Stephen L Hoffman Sean C Murphy Source Type: research
Malaria vaccines to moderate the impact of antibiotic resistance in endemic countries
J Med Microbiol. 2023 Jul;72(7). doi: 10.1099/jmm.0.001734.ABSTRACTSwift and widespread deployment of an efficient malaria vaccine in Pakistan, together with basic control and preventive measures, could significantly decrease the economic and healthcare burden caused by drug-resistant malaria. Moreover, the RTS,S/AS01 vaccine has provided a much needed breakthrough after decades of growth, as an innovative vaccine for malaria in phase 3 clinical trials and currently undergoing implementation studies. Vaccination is a potentially critical component of efforts to arrest the development and dissemination of antimicrobial resi...
Source: Journal of Medical Microbiology - July 26, 2023 Category: Microbiology Authors: Maria Khan Saba Khan Source Type: research
Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein
Trends Parasitol. 2023 Jul 21:S1471-4922(23)00147-2. doi: 10.1016/j.pt.2023.06.011. Online ahead of print.ABSTRACTMalaria caused by the Plasmodium vivax parasite is a major global health burden. Immunity against blood-stage infection reduces parasitemia and disease severity. Duffy-binding protein (DBP) is the primary parasite protein responsible for the invasion of red blood cells and it is a leading subunit vaccine candidate. An effective vaccine, however, is still lacking despite decades of interest in DBP as a vaccine candidate. This review discusses the reasons for targeting DBP, the challenges associated with developi...
Source: Trends in Parasitology - July 22, 2023 Category: Parasitology Authors: Thayne H Dickey Niraj H Tolia Source Type: research
HBV Infection Is an Intermediate-Risk Disease, Whereas Anaemia Is a Mild-to-Moderate Public Health Problem in Young Ghanaian Adults: A Four-Year Retrospective Analysis of Students' Medical Records
CONCLUSION: Intentional preventative public health campaigns regarding anaemia, HBV, and HCV infection should, respectively, target females and young adult males to increase chances of making real change in behavioural attitudes in these at-risk groups.PMID:37475793 | PMC:PMC10356218 | DOI:10.1155/2023/9318984
Source: Biomed Res - July 21, 2023 Category: Research Authors: Samuel Amoah Andrew Nicholas Yartey Praise Fosu Adjei Margaret Owusu-Akyaw Joseph Boachie David Larbi Simpong Patrick Adu Source Type: research
