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Total 3598 results found since Jan 2013.
The Man Who Thinks He Can Live Forever
In a neat little neighborhood in Venice, Calif., there’s a block of squat, similar homes, filled with mortals spending their finite days on the planet eating pizza with friends, blowing out candles on birthday cakes, and binging late-night television. Halfway down the street, there’s a cavernous black modern box. This is where Bryan Johnson is working on what he calls “the most significant revolution in the history of Homo sapiens.”
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Johnson, 46, is a centimillionaire tech entrepreneur who has spent most of the last three years in pursuit of a si...
Source: TIME: Health - September 20, 2023 Category: Consumer Health News Authors: Charlotte Alter Tags: Uncategorized feature Source Type: news
Molecules, Vol. 28, Pages 6689: Effect of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench, Euterpe oleracea Martius, Bixa orellana Linn & eacute; and Chronic SM & reg; on Atherogenic Dyslipidemia in Wistar Rats
This study investigated the effects of treatments with oils from A. esculentus, E. oleracea, B. orellana, and Chronic SM® on Cocos nucifera L. saturated-fat-induced dyslipidemia. The chromatographic profile showed the majority presence of unsaturated fatty acids in the tested oils. The quantification of tocotrienols and geranylgeraniol in OFBO and CHR was obtained. Treatments with OFEO, OFAE, OFBO, and CHR were able to significantly reduce glycemia, as well as hypertriglyceridemia, total cholesterol, and LDL-cholesterol, besides increasing HDL-cholesterol. The treatments inhibited the formation of atheromatous ...
Source: Molecules - September 19, 2023 Category: Chemistry Authors: Priscila Faimann Sales Aline Lopes do Nascimento Fernanda Cavalcante Pinheiro Andressa Ketelem Meireles Alberto Abrah ão Victor Tavares de Lima Teixeira dos Santos Helison de Oliveira Carvalho Gisele Cust ódio de Souza Jos é Carlos Tavares Carvalho Tags: Article Source Type: research
GSE203300 Effect of thermoneutral housing conditions on the hepatotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male C57BL/6 mice
Contributors : Warren Sink ; Rance Nault ; Tim R ZacharewskiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTypical rodent toxicology experiments are performed at human thermoneutral temperatures (thermostandard; TS = 20 – 24° C). Reports have indicated that investigation of metabolic endpoints at mouse thermoneutral temperatures (TNM = 28 – 30° C) improves translation to humans when they are not chronically cold-stressed. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been shown to dose-dependently induce metabolic disease in mice at including liver steatosis, steatohepatitis...
Source: GEO: Gene Expression Omnibus - September 18, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research
CONCLUSIONS: In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.PMID:37706321 | DOI:10.1161/ATVBAHA.123.319922
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Allison M Dubner Sizhao Lu Austin J Jolly Tysen Noble Tyler Hinthorn Raphael A Nemenoff Karen S Moulton Mark W Majesky Mary C M Weiser-Evans Source Type: research
Proniosomes Nanoparticle for the Treatment of Peripheral Arterial Disease
CONCLUSION: Proniosomes may be created using various techniques, which may impact how they develop along with the drug's characteristics. They increase the drug's stability while being delivered while being entrapped. They don't need particular conditions for handling, protection, storage, or industrial manufacturing.PMID:37702235 | DOI:10.2174/2211738511666230912160729
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Preyash A Panchal Shruti Patel Asha Patel Priyanka Ahlawat Source Type: research
Dietary palm oil enhances SREBP2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker ( < em > Larimichthys crocea < /em > )
Br J Nutr. 2023 Sep 13:1-27. doi: 10.1017/S0007114523001344. Online ahead of print.ABSTRACTSterol regulatory element-binding protein 2 (SREBP2) is considered to be a major regulator to control cholesterol homeostasis in mammals. However, the role of SREBP2 in teleost remains poorly understand. Here, we explored the molecular characterization of SREBP2 and identified SREBP2 as a key modulator for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and 7-dehydrocholesterol reductase (DHCR7) which were rate-limiting enzymes of cholesterol biosynthesis. Moreover, dietary palm oil (PO) in vivo or palmitic acid (PA) treatmen...
Source: The British Journal of Nutrition - September 12, 2023 Category: Nutrition Authors: Zengqi Zhao Baolin Li Qiang Chen Xiaojun Xiang Xiang Xu Shangzhe Han Wencong Lai Yueru Li Wei Xu Kangsen Mai Qinghui Ai Source Type: research
