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Total 322 results found since Jan 2013.
MiR-601-induced BMSCs senescence accelerates steroid-induced osteonecrosis of the femoral head progression by targeting SIRT1
CONCLUSIONS: Considering the role of BMSCs aging in the progression of SONFH, this provides a new idea for the prevention and treatment of SONFH.PMID:37597099 | DOI:10.1007/s00018-023-04903-8
Source: Cellular and Molecular Life Sciences : CMLS - August 19, 2023 Category: Cytology Authors: Boyu Tang Yu Chen Pei Zhao Wenlong Yan Xiao Huang Weiqian Jiang Mingjie Sun Hongrui Zhang Dulei Xiang Tingmei Chen Chengjie Lian Jian Zhang Source Type: research
Anticancer potentials of metformin loaded coconut oil nanoemulsion on MCF-7, HepG2 and HCT-116 cell lines
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):419-427. doi: 10.1080/21691401.2023.2246145.ABSTRACTIn order to load metformin in a nano formula and evaluate the produced nano form towards cancer cells, metformin was loaded on natural carrier coconut oil. The formed metformin-loaded coconut oil nanoemulsion was characterized by Zeta potential, particle size, drug content, drug release, and drug stability. The formed nanoemulsion was evaluated towards MCF-7, HepG2, and HCT-116 cell lines. Cell cycle analysis and apoptosis mechanism were studied. The nanoemulsion was created using deionized water, 1.5% Span 20, 1.5% Tween 80,...
Source: Artificial Cells, Nanomedicine and Biotechnology - August 17, 2023 Category: Biotechnology Authors: Hadil Faris Alotaibi El-Sayed Khafagy Amr Selim Abu Lila Haifa F Alotaibe Serag Eldin Elbehairi Ashwag S Alanazi Mohammad Y Alfaifi Jawaher Abdullah Alamoudi Sarah Salem Alamrani Fatma Alzahraa Mokhtar Source Type: research
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Levels of PLG...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species.
We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metformin alleviates the cognitive impairment induced by benzoapyrene via glucolipid metabolism regulated by FTO/FoxO6 pathway in mice
In this study, we assessed the intervention effect of metformin (MET) on cognitive dysfunction in mice induced by B[a]P from the perspective of glucolipid metabolism. Forty-two male healthy ICR mice were randomly categorized into 6 groups and were gavaged with B[a]P (0, 2.5, 5, or 10 mg/kg), 45 times for 90 days. The controls were gavaged with edible peanut oil, and the intervention groups were co-treated with B[a]P (10 mg/kg) and MET (200 or 300 mg/kg). We assessed the cognitive function of mice, observed the pathomorphological and ultrastructural changes, and detected neuronal apoptosis and glucolipid metabolism. Results...
Source: Environmental Science and Pollution Research International - May 3, 2023 Category: Environmental Health Authors: Tingyi Zhao Huide Miao Zhanfei Song Yangyang Li Na Xia Zhiyan Zhang Hongmei Zhang Source Type: research
JianPi-QingHua formula attenuates nonalcoholic fatty liver disease by regulating the AMPK/SIRT1/NF- κB pathway in high-fat-diet-fed C57BL/6 mice
CONCLUSIONS: These findings indicate that JPQH supplementation protected against HFD-induced NAFLD by regulating SIRT1/AMPK/NF-κB pathway, which provides a theoretical basis for the clinical treatment of patients with NAFLD.PMID:37038833 | DOI:10.1080/13880209.2023.2188549
Source: Pharmaceutical Biology - April 11, 2023 Category: Drugs & Pharmacology Authors: Jing Tian Mengjie Cai Shenyi Jin Qingguang Chen Jiahui Xu Qiuyue Guo Zihui Yan Xu Han Hao Lu Source Type: research
