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Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo
Thermoxidation of edible oil through deep fat frying results in the generation of several oxidized products that promote lipid peroxidation and ROS production when eaten. Consumption of thermoxidized oil in po...
Source: Lipids in Health and Disease - July 26, 2023 Category: Lipidology Authors: Joy Temiloluwa Folahan, Olufunke Esan Olorundare, Abayomi Mayowa Ajayi, Adeoye Oyetunji Oyewopo, Sunday Sokunle Soyemi, Adejuwon Adewale Adeneye, Ikechukwu Innocent Okoye, Saheed Olanrewaju Afolabi and Anoka Ayembe Njan Tags: Research Source Type: research
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice
In this study, 1 mg/kg of cadmium chloride (CdCl2) was injected intraperitoneally every other day in 8-week-old C57BL/6 J male mice to study the effects on their female offspring. Our results showed an increase in body weight, water intake and food intake in F1 female mice from the Cd-exposed group. The development of secondary follicles and antral follicles in the ovaries of Cd-treated was inhibited. Serum estradiol (E2) was found to be decreased. Further analysis revealed significant downregulation of StAR, P450scc, 17β-HSD, CYP17A1 and CYP19A1, which are related to E2 synthesis. Serum total cholesterol was increased an...
Source: Ecotoxicology and Environmental Safety - July 23, 2023 Category: Environmental Health Authors: Yanwei Zhang Jinzhao Zhou Ling Zeng Yifan Xiong Xiaofei Wang Wenpei Xiang Ping Su Source Type: research
Environmentally relevant doses of endocrine disrupting chemicals affect male fertility by interfering with sertoli cell glucose metabolism in mice
Chemosphere. 2023 Jun 24:139277. doi: 10.1016/j.chemosphere.2023.139277. Online ahead of print.ABSTRACTThe growing global deterioration in several aspects of human health has been partly attributed to hazardous effects of endocrine-disrupting chemicals (EDCs) exposure. Therefore, experts and government regulatory agencies have consistently advocated for studies on the combined effects of EDCs that model human exposure to multiple environmental chemicals in real life. Here, we investigated how low concentrations of bisphenol A (BPA), and phthalates compounds affect the Sertoli cell glucose uptake/lactate production in the t...
Source: Chemosphere - June 26, 2023 Category: Chemistry Authors: Elikanah Olusayo Adegoke Md Saidur Rahman Shehreen Amjad Won-Ki Pang Do-Yeal Ryu Yoo-Jin Park Mung-Geol Pang Source Type: research
Pancreastatin deteriorates hepatic lipid metabolism via elevating fetuin B in ovariectomized rats
Biochimie. 2023 Jun 24:S0300-9084(23)00144-X. doi: 10.1016/j.biochi.2023.06.006. Online ahead of print.ABSTRACTHepatic steatosis is an important mstetabolic complication in women encountering postmenopausal phase of life. Pancreastatin (PST), has previously been investigated in diabetic and insulin resistant rodents. The present study highlighted the role of PST in ovariectomized rats. Female SD rats were ovariectomized and subsequently fed high fructose diet for 12 weeks. PST inhibitor peptide was intraperitoneally administered for 14 days and further examined for insulin resistance, glucose intolerance development, body ...
Source: Biochimie - June 26, 2023 Category: Biochemistry Authors: Pragati Singh Mohammad Irshad Reza Anees A Syed Athar Husain Jiaur R Gayen Source Type: research
Environmentally relevant doses of endocrine disrupting chemicals affect male fertility by interfering with sertoli cell glucose metabolism in mice
Chemosphere. 2023 Jun 24:139277. doi: 10.1016/j.chemosphere.2023.139277. Online ahead of print.ABSTRACTThe growing global deterioration in several aspects of human health has been partly attributed to hazardous effects of endocrine-disrupting chemicals (EDCs) exposure. Therefore, experts and government regulatory agencies have consistently advocated for studies on the combined effects of EDCs that model human exposure to multiple environmental chemicals in real life. Here, we investigated how low concentrations of bisphenol A (BPA), and phthalates compounds affect the Sertoli cell glucose uptake/lactate production in the t...
Source: Chemosphere - June 26, 2023 Category: Chemistry Authors: Elikanah Olusayo Adegoke Md Saidur Rahman Shehreen Amjad Won-Ki Pang Do-Yeal Ryu Yoo-Jin Park Mung-Geol Pang Source Type: research
Pancreastatin deteriorates hepatic lipid metabolism via elevating fetuin B in ovariectomized rats
Biochimie. 2023 Jun 24:S0300-9084(23)00144-X. doi: 10.1016/j.biochi.2023.06.006. Online ahead of print.ABSTRACTHepatic steatosis is an important mstetabolic complication in women encountering postmenopausal phase of life. Pancreastatin (PST), has previously been investigated in diabetic and insulin resistant rodents. The present study highlighted the role of PST in ovariectomized rats. Female SD rats were ovariectomized and subsequently fed high fructose diet for 12 weeks. PST inhibitor peptide was intraperitoneally administered for 14 days and further examined for insulin resistance, glucose intolerance development, body ...
Source: Biochimie - June 26, 2023 Category: Biochemistry Authors: Pragati Singh Mohammad Irshad Reza Anees A Syed Athar Husain Jiaur R Gayen Source Type: research
No detectable changes in anxiety-related and locomotor behaviors in adult ovariectomized female rats exposed to estradiol, the ER β agonist DPN or the ERα agonist PPT
Horm Behav. 2023 Apr 21;152:105363. doi: 10.1016/j.yhbeh.2023.105363. Online ahead of print.ABSTRACTThe sex steroid hormone 17β-estradiol (estradiol) and its Estrogen Receptors (ERs) have been linked to modulation of anxiety-related and locomotor behaviors in female rodents. Research suggests that estradiol mitigates anxiety-related behaviors through activating Estrogen Receptor (ER)β and increases locomotor behaviors through ERα. The influence of ERs on these behaviors cannot always be detected. Here we discuss two experiments in which we tested the hypothesis that anxiety-related behaviors would decrease after ERβ ac...
Source: Hormones and Behavior - April 23, 2023 Category: Endocrinology Authors: Christiana K Miller John Meitzen Source Type: research
Dietary n-3 PUFA augments pre-ovulatory follicle turnover and prolificacy in well-fed ewes
Anim Reprod Sci. 2023 Apr 12;252:107231. doi: 10.1016/j.anireprosci.2023.107231. Online ahead of print.ABSTRACTThe present study evaluated the effect of dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) on preovulatory follicle (POF) turnover, prolificacy, and endocrine and metabolic milieu in Malpura sheep. Fifty cyclic ewes with 3-3.5 body condition scores on a five-point scale were allocated equally to two groups (n = 25) following estrus synchronization and were supplemented with 0.6 mL/kg body weight of n-3 PUFA-rich fish oil (FO) or palm oil (PO) as control, for 60 d following an acclimatization per...
Source: Animal Reproduction Science - April 22, 2023 Category: Zoology Authors: Ajit Singh Mahla Suresh Kumar Bunkar Babu Lal Kumawat Vijay Kumar Saxena Sellappan Selvaraju Randhir Singh Bhatt Raghvendar Singh Arun Kumar Source Type: research
