Filtered By:
Drug: Insulin

This page shows you your search results in order of date.

Order by Relevance | Date

Total 2234 results found since Jan 2013.

Obesity promotes a leaky gut, inflammation and pre-diabetes by lowering gut microbiota that metabolise ethanolamine
Microbiota are a source of low-grade inflammation during obesity and contribute to insulin resistance and poor blood glucose control among other mechanisms in the progression of type 2 diabetes.1 Nearly all bacteria that reside within the host are found in the intestine, but it is not yet clear how microbiota are a source of inflammation in the circulation or metabolic tissues during obesity. A key knowledge gap is understanding how obesity or certain diets promote gut barrier dysfunction that allows increased permeability for bacteria or bacterial components that can engage immune response and promote inflammation-induced...
Source: Gut - September 13, 2023 Category: Gastroenterology Authors: Fang, H., e-Lacerda, R. R., Schertzer, J. D. Tags: Gut Commentary Source Type: research

Fixed
I confiscate mangoes. Rip wrinkled skin until I draw blood. Hold an ice-cold hand. “We can fix this.” Lock a door. Lock a cabinet. Sit through a meeting. Tell a mother her child is dying. Eat a turkey sandwich. Teach a family member how to drain fluid from the lungs. Refill my water bottle. “We will fix this.” Refill my caffeine pill bottle. Prescribe insulin. Find a new p laylist of upbeat songs. Take baby steps to avoid disturbing the sleeping giant. Run. Sign a death certificate. Run. Push pain  medication into someone’s vein. Run. Tape someone’s eyes closed. Discuss weekend plans. Admire the tenacity of...
Source: JAMA - September 12, 2023 Category: General Medicine Source Type: research

Chronic unpredictable mild stress promotes atherosclerosis < em > via < /em > adipose tissue dysfunction in ApoE < sup > -/- < /sup > mice
CONCLUSIONS: These findings indicated that CUMS induces adipose tissue dysfunction via a mechanism that leads to dyslipidemia, increased inflammation, and insulin resistance in the body, thereby exacerbating atherosclerosis. Notably, CUMS that is involved in decreasing the expression of HDL-associated proteins in adipose tissue may be a crucial link between adipose hypertrophy and advanced atherosclerosis. This study reveals a novel mechanism via which CUMS exacerbates atherosclerosis from the novel perspective of abnormal adipose function and identifies a novel potential therapeutic target for this disease.PMID:37692113 |...
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Min Mao Yalan Deng Li Wang Gexin Zhao Ruomei Qi Huan Gong Tao Shen Yitian Xu Deping Liu Beidong Chen Source Type: research

Double layer spherical Nanoparticles with Hyaluronic Acid Coating to Enhance Oral Delivery of Exenatide in T2DM rats
Eur J Pharm Biopharm. 2023 Sep 6:S0939-6411(23)00236-9. doi: 10.1016/j.ejpb.2023.09.003. Online ahead of print.ABSTRACTSoybean phospholipid was used as an amphiphilic material to form reverse micelles (RMs) in medium glycerol monolinoleate (Maisine) with Exenatide (EXT.) encapsulated in the polar core formed by the hydrophilic part of phospholipid. Cremopher RH40 and caprylocaproyl macrogol-8 glycerides EP/caprylocaproyl polyoxyl-8 glycerides NF (Labrasol) were added as surfactants to prepare reverse micelle-self emulsifying drug delivery system (RMs-SEDDS). On this basis, oil in water (O/W) emulsion was further prepared. ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 8, 2023 Category: Drugs & Pharmacology Authors: Yiying Lu Linjie Wu Mengting Lin Xiaoyan Bao Haiqing Zhong Peng Ke Qi Dai Qiyao Yang Xinjiang Tang WenHong Xu DongHang Xu Min Han Source Type: research

Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Asprosin contributes to nonalcoholic fatty liver disease through regulating lipid accumulation and inflammatory response via AMPK signaling
ConclusionCollectively, Asprosin inhibition suppressed lipid accumulation and inflammation to obstruct NAFLD through AMPK/p38 signaling.
Source: Immunity, Inflammation and Disease - August 19, 2023 Category: Allergy & Immunology Authors: Bo Zhang, Jinger Lu, Yuhua Jiang, Yan Feng Tags: ORIGINAL ARTICLE Source Type: research

Resveratrol improves palmitic acid ‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells
In conclusion, RSV may improve PA‑induced IR in C2C12 cells through the DDIT4/mTOR/IRS‑1/PI3K/AKT/GLUT4 signaling pathway, as well as via improvements in glucose and lipid metabolism.PMID:37594055 | DOI:10.3892/mmr.2023.13068
Source: Molecular Medicine Reports - August 18, 2023 Category: Molecular Biology Authors: Xinyan Pan Chunqiao Liu Xing Wang Ming Zhao Zhimei Zhang Xuemei Zhang Chao Wang Guangyao Song Source Type: research

Metabolic and molecular effects of dietary extra virgin olive oil in blood and placenta of women with GDM
ConclusionsWe identified novel beneficial effects of an EVOO-enriched diet in GDM women, a diet capable of regulating maternal insulin resistance, the structure and metabolism of the placenta, and the placental endocytic pathway, suggesting effects that may be beneficial for fetal development.
Source: Frontiers in Endocrinology - August 15, 2023 Category: Endocrinology Source Type: research

An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD
This study provides evidence that SLC25A3 is a novel risk factor for developing NASH.PMID:37557977 | DOI:10.1016/j.yexcr.2023.113740
Source: Experimental Cell Research - August 9, 2023 Category: Cytology Authors: Takeo Nakanishi Yuki Kawasaki Yoshinobu Nakamura Yuuki Kimura Kotone Kawamura Melody N Shumba Noriaki Shimokawa Source Type: research