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Total 1325 results found since Jan 2013.

NIH sticks to new requirement that foreign partners share lab notebooks
The National Institutes of Health (NIH) is standing firm on a new mandate requiring partners abroad to periodically share lab notebooks and other raw data with their main grant recipient in the United States. Hundreds of researchers and organizations had urged the agency to drop or narrow the rule because they warned it could impede foreign collaborations, particularly in developing countries. Although the final policy announced today has a few tweaks, such as requiring that notebooks and other data be shared once a year instead of every few months as was originally proposed, it is largely unchanged from a plan releas...
Source: Science of Aging Knowledge Environment - September 15, 2023 Category: Geriatrics Source Type: research

News at a glance: Sustainable Development Goals, CO2 removal, and hominin fossils in space
POLICY Scientists call for revamped Sustainable Development Goals New analyses confirm the world is failing to meet the Sustainable Development Goals, a set of ambitious objectives agreed to in 2015 by the United Nations, and scientists are among those calling for a reboot. The 17 goals include ending poverty and hunger and ensuring sustainable consumption by 2030. To meet them, the agreement includes 169 specific targets, but skeptics have long contended that many are not well defined, measurable, and scientifically rigorous. In an independent analysis the U.N. will publish next week ahead of a meeting it i...
Source: ScienceNOW - September 14, 2023 Category: Science Source Type: news

CIA bribed its own COVID-19 origin team to reject lab-leak theory, anonymous whistleblower claims
An unnamed CIA whistleblower has made the dramatic allegation that six analysts there were bribed to reject the theory that COVID-19 resulted from a research-related leak of a new coronavirus, according to a press release today from the office of the Republican leading a congressional investigation into the pandemic. The allegation was strongly rejected in a CIA statement released hours later. A majority of U.S. intelligence agencies has so far concluded that the COVID-19 pandemic mostly likely started when SARS-CoV-2 jumped from an infected animal host into people; a wildlife market in Wuhan, China, has receive...
Source: ScienceNOW - September 12, 2023 Category: Science Source Type: news

Recombination in sarbecovirus lineage and mutations/insertions in spike protein are linked to the emergence and adaptation of SARS-CoV-2
Bioinformation. 2022 Oct 31;18(10):951-961. doi: 10.6026/97320630018951. eCollection 2022.ABSTRACTThe outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan city, China in December 2019 and thereafter its spillover across the world has created a global pandemic and public health crisis. Right after, there has been intense interest in understanding how the SARS-CoV-2 originated and evolved. This paper also aims to shed light on the origin and evolution of SARS-CoV- 2. A consensus result based on whole genome phylogeny, gene tree analysis, and genetic similarity study revealed that SARS-CoV-2 evolv...
Source: Bioinformation - September 11, 2023 Category: Bioinformatics Authors: Anup Som Amresh Kumar Sharma Priyanka Kumari Source Type: research

Mild to moderate post-COVID-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity level — an observational sub-analysis fit- COVID study
ConclusionYoung adults after mild-to-moderate SARS-CoV-2 infection appeared to have lower physical activity levels, which can be associated with clinical and immunometabolic responses in a complex manner.
Source: Frontiers in Immunology - September 11, 2023 Category: Allergy & Immunology Source Type: research

The Question of the Origins of COVID-19 and the Ends of Science
AbstractIntense public interest in scientific claims about COVID-19, concerning its origins, modes of spread, evolution, and preventive and therapeutic strategies, has focused attention on the values to which scientists are assumed to be committed and the relationship between science and other public discourses. A much discussed claim, which has stimulated several inquiries and generated far-reaching political and economic consequences, has been that SARS-CoV-2 was deliberately engineered at the Wuhan Institute of Virology and then, either inadvertently or otherwise, released to the public by a laboratory worker. This has ...
Source: Journal of Bioethical Inquiry - September 11, 2023 Category: Medical Ethics Source Type: research

U.S. cancels program aimed at identifying potential pandemic viruses
In what many see as fallout from the concern that researchers studying bat viruses may have triggered the COVID-19 pandemic, the U.S. Agency for International Development (USAID) has prematurely ended a $125 million program aimed at identifying viruses in animals that might harm humans. USAID launched the program, known as the Discovery & Exploration of Emerging Pathogens – Viral Zoonoses (DEEP VZN), in October 2021. It tapped the Paul G. Allen School for Global Health at Washington State University (WSU) to lead a consortium that planned to work in up to 12 foreign countries over 5 years. Goals included trainin...
Source: Science of Aging Knowledge Environment - September 8, 2023 Category: Geriatrics Source Type: research

Viruses, Vol. 15, Pages 1897: Genotype and Phenotype Characterization of Rhinolophus sp. Sarbecoviruses from Vietnam: Implications for Coronavirus Emergence
r Vu Dinh Thong Sylvie van der Werf Vu Sinh Nam Marc Eloit Bats are a major reservoir of zoonotic viruses, including coronaviruses. Since the emergence of SARS-CoV in 2002/2003 in Asia, important efforts have been made to describe the diversity of Coronaviridae circulating in bats worldwide, leading to the discovery of the precursors of epidemic and pandemic sarbecoviruses in horseshoe bats. We investigated the viral communities infecting horseshoe bats living in Northern Vietnam, and report here the first identification of sarbecoviruses in Rhinolophus thomasi and Rhinolophus siamensis bats. Phylogenetic chara...
Source: Viruses - September 8, 2023 Category: Virology Authors: Sarah Temmam Tran Cong Tu B éatrice Regnault Massimiliano Bonomi Delphine Chr étien L éa Vendramini Tran Nhu Duong Tran Vu Phong Nguyen Thi Yen Hoang Ngoc Anh Tran Hai Son Pham Tuan Anh Faustine Amara Thomas Bigot Sandie Munier Vu Dinh Thong Sylvie van Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1890: Multiplex One-Step RT-qPCR Assays for Simultaneous Detection of SARS-CoV-2 and Other Enteric Viruses of Dogs and Cats
In conclusion, these newly developed one-step multiplex RT-qPCR assays allow for rapid diagnosis of enteric viral infections, including SARS-CoV-2, in dogs and cats.
Source: Viruses - September 7, 2023 Category: Virology Authors: C ôme J. Thieulent Mariano Carossino Laura Peak Wendy Wolfson Udeni B. R. Balasuriya Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1728: Analysis of SARS-CoV-2 Population Genetics from Samples Associated with Huanan Market and Early Cases Identifies Substitutions Associated with Future Variants of Concern
cox SARS-CoV-2 began spreading through human-to-human transmission first within China and then worldwide, with increasing sequence diversity associated with time and the further spread of the virus. The spillover events in the Huanan market were associated with two lineages of SARS-CoV-2 (lineages A and B). Infecting virus populations and those in infected individuals consist of a dominant genomic sequence and minor genomic variants; these latter populations can indicate sites on the genome that may be subject to mutational changes—either neutral or advantageous sites and those that act as a reservoir for...
Source: Viruses - August 12, 2023 Category: Virology Authors: Xiaofeng Dong Julian A. Hiscox Tags: Article Source Type: research

A dual fragment triggered DNA ladder nanostructure based on logic gate and dispersion-to-localization catalytic hairpin assembly for efficient fluorescence assay of SARS-CoV-2 and H1N1
Anal Chim Acta. 2023 Sep 22;1275:341590. doi: 10.1016/j.aca.2023.341590. Epub 2023 Jul 10.ABSTRACTDNA nanotechnology has been widely utilized in the construction of various functional nanostructures. However, most DNA nanostructures have the shortcomings of low response rate and serious background leakage. Herein, we proposed the conception of AND logic gate cascaded dispersion-to-localization catalytic hairpin assembly (AND gate-DLCHA) for the fabrication of novel DNA ladder nanostructures. In our design, the entropy-driven AND logic gate can precisely recognize two fragments of the target nucleic acid sequences. After AN...
Source: Analytica Chimica Acta - July 31, 2023 Category: Chemistry Authors: Chen Zhou Yujing Chuai Chiliang Lin Dongsheng Wang Qiuju Wang Haimin Zou Source Type: research