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News at a glance: Diphtheria vaccine shortage, prisoner release, and iNaturalist ’s growth
CONSERVATION Popular biodiversity app to expand The nonprofit that runs iNaturalist, a popular app and website for identifying species, has received a $10 million grant to expand. The funding from the Gordon and Betty Moore Foundation, announced last week, will allow iNaturalist—whose website is one of the largest generators of crowd-sourced species-occurrence data—to add users, technology, and observations to inform conservation. iNaturalist hopes to grow in nature-rich parts of the world, such as Asia and South America, which have fewer users uploading data. Since iNaturalist’s founding in 2008, the ...
Source: Science of Aging Knowledge Environment - September 21, 2023 Category: Geriatrics Source Type: research

News at a glance: Diphtheria treatment shortage, prisoner release, and iNaturalist ’s growth
CONSERVATION Popular biodiversity app to expand The nonprofit that runs iNaturalist, a popular app and website for identifying species, has received a $10 million grant to expand. The funding from the Gordon and Betty Moore Foundation, announced last week, will allow iNaturalist—whose website is one of the largest generators of crowd-sourced species-occurrence data—to add users, technology, and observations to inform conservation. iNaturalist hopes to grow in nature-rich parts of the world, such as Asia and South America, which have fewer users uploading data. Since iNaturalist’s founding in 2008, the ...
Source: ScienceNOW - September 21, 2023 Category: Science Source Type: news

Leaking Gut, Leaking Blood Vessels, Leaking Blood Brain Barrier
In today's open access paper, researchers attempt to throw a big tent over three distinct issues in the aging of the body and brain. Firstly, the intestinal barrier fails, allowing bacteria and bacterial metabolites into tissue and the circulation, where they can provoke dysfunction and inflammation. Secondly, blood vessels become leaky, harming surrounding tissues by allowing excessive fluid, inappropriate molecules and cells to escape. Lastly, the blood-brain barrier leaks; this is a more specialized barrier layer surrounding blood vessels in the brain, and when it leaks, the passage of unwanted cells and molecules into ...
Source: Fight Aging! - September 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Rare variants in complement system genes associate with endothelial damage after pediatric allogeneic hematopoietic stem cell transplantation
DiscussionInjury to the vascular endothelium is relatively common after HSCT with different phenotypic appearances suggesting yet unidentified underlying mechanisms. Variants in complement components may be related to endotheliopathy and poor prognosis in these patients.
Source: Frontiers in Immunology - September 13, 2023 Category: Allergy & Immunology Source Type: research

A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut
Conclusion Overall, we discovered that the reduced capacity of obese microbiota to metabolise ethanolamine instigates gut permeability, inflammation and glucose metabolic dysfunctions, and restoring ethanolamine-metabolising capacity by a novel probiotic therapy reverses these abnormalities. Trial registration number NCT02869659 and NCT03269032.
Source: Gut - September 13, 2023 Category: Gastroenterology Authors: Mishra, S. P., Wang, B., Jain, S., Ding, J., Rejeski, J., Furdui, C. M., Kitzman, D. W., Taraphder, S., Brechot, C., Kumar, A., Yadav, H. Tags: Open access, Gut Gut microbiota Source Type: research

Interventional Treatment Methods for Ureteral Complications After Kidney Transplant: A Single-Center Experience
CONCLUSIONS: Ureteral complications after kidney transplant can be successfully treated with interventional methods in experienced centers without the need for surgery.PMID:37698400 | DOI:10.6002/ect.2023.0236
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Özgür Özen Emre Karakaya Tolga Zeydanl ı G ökhan Kahraman Sedat Y ıldırım Fatih Boyvat Mehmet Haberal Source Type: research

Ureterovesical Leak Following Renal Transplant and Effects of Acute Rejection and Antirejection Therapy: A Nested Case-Control Analysis and Outcome of 1102 Consecutive Renal Transplant Recipients
CONCLUSIONS: Nontechnical risk factors that cause posttransplant ureteric leak include older donor and recipient age and ABO incompatible and 6/6 HLA mismatch transplants. Acute rejection and plasmapheresis predispose leak, and an indwelling double J stent can allow adequate healing of the anastomosis. High index of suspicion and prompt management are imperative to preserve graft and patient outcome.PMID:37698398 | DOI:10.6002/ect.2023.0004
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Akshay Kriplani Sanjoy Kumar Sureka Anil Mani Sanchit Rustagi Uday Pratap Singh M S Ansari Narayan Prasad Harshita Sharma Aneesh Srivastava Source Type: research

Interventional Treatment Methods for Ureteral Complications After Kidney Transplant: A Single-Center Experience
CONCLUSIONS: Ureteral complications after kidney transplant can be successfully treated with interventional methods in experienced centers without the need for surgery.PMID:37698400 | DOI:10.6002/ect.2023.0236
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Özgür Özen Emre Karakaya Tolga Zeydanl ı G ökhan Kahraman Sedat Y ıldırım Fatih Boyvat Mehmet Haberal Source Type: research

Ureterovesical Leak Following Renal Transplant and Effects of Acute Rejection and Antirejection Therapy: A Nested Case-Control Analysis and Outcome of 1102 Consecutive Renal Transplant Recipients
CONCLUSIONS: Nontechnical risk factors that cause posttransplant ureteric leak include older donor and recipient age and ABO incompatible and 6/6 HLA mismatch transplants. Acute rejection and plasmapheresis predispose leak, and an indwelling double J stent can allow adequate healing of the anastomosis. High index of suspicion and prompt management are imperative to preserve graft and patient outcome.PMID:37698398 | DOI:10.6002/ect.2023.0004
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Akshay Kriplani Sanjoy Kumar Sureka Anil Mani Sanchit Rustagi Uday Pratap Singh M S Ansari Narayan Prasad Harshita Sharma Aneesh Srivastava Source Type: research

Interventional Treatment Methods for Ureteral Complications After Kidney Transplant: A Single-Center Experience
CONCLUSIONS: Ureteral complications after kidney transplant can be successfully treated with interventional methods in experienced centers without the need for surgery.PMID:37698400 | DOI:10.6002/ect.2023.0236
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Özgür Özen Emre Karakaya Tolga Zeydanl ı G ökhan Kahraman Sedat Y ıldırım Fatih Boyvat Mehmet Haberal Source Type: research

Ureterovesical Leak Following Renal Transplant and Effects of Acute Rejection and Antirejection Therapy: A Nested Case-Control Analysis and Outcome of 1102 Consecutive Renal Transplant Recipients
CONCLUSIONS: Nontechnical risk factors that cause posttransplant ureteric leak include older donor and recipient age and ABO incompatible and 6/6 HLA mismatch transplants. Acute rejection and plasmapheresis predispose leak, and an indwelling double J stent can allow adequate healing of the anastomosis. High index of suspicion and prompt management are imperative to preserve graft and patient outcome.PMID:37698398 | DOI:10.6002/ect.2023.0004
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Akshay Kriplani Sanjoy Kumar Sureka Anil Mani Sanchit Rustagi Uday Pratap Singh M S Ansari Narayan Prasad Harshita Sharma Aneesh Srivastava Source Type: research