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Vaccination: Influenza Vaccine
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Total 174 results found since Jan 2013.
Prediction of highly pathogenic avian influenza vaccine efficacy in chickens by comparison of in vitro and in vivo data: A meta-analysis and systematic review
Vaccine. 2023 Aug 1:S0264-410X(23)00922-2. doi: 10.1016/j.vaccine.2023.07.076. Online ahead of print.ABSTRACTVaccines for avian influenza (AI) can protect poultry against disease, mortality, and virus transmission. Numerous factors, including: vaccine platform, immunogenicity, and relatedness to the field strain, are known to be important to achieving optimal AI vaccine efficacy. To better understand how these factors contribute to vaccine protection, a systematic meta-analysis was conducted to evaluate efficacy data for vaccines in chickens challenged with highly pathogenic (HP) AI. Data from a total of 120 individual tri...
Source: Vaccine - August 3, 2023 Category: Allergy & Immunology Authors: Jongseo Mo Erica Spackman David E Swayne Source Type: research
Is a ‘polyepidemic’ humanity’s next big threat? Childhood vaccine crusader shares concerns for future
By the start of 2011, the year epidemiologist Seth Berkley became CEO of Gavi, the Vaccine Alliance, the ambitious nonprofit had over its 11-year history supported the immunization of 288 million children in poor countries. But it also had a $3.7 billion funding gap between its plans and donor financial pledges. Making matters worse, an internal battle raged about how much it should invest in strengthening health systems versus more technological solutions, such as new or improved vaccines, favored by its main funder, the Bill & Melinda Gates Foundation. “It was a crisis,” Berkley says.
Berkley plans to step d...
Source: ScienceNOW - July 20, 2023 Category: Science Source Type: news
Optimization of infectious bronchitis virus-like particle expression in < i > Nicotiana benthamiana < /i > as potential poultry vaccines
In this study, using theAgrobacterium-mediatedNicotiana benthamiana (tobacco plant) transient expression system, the highest levels of VLPs displaying a modified S protein of a QX-like IB variant were obtained when the native transmembrane (TM) domain and cytoplasmic tail were substituted with that of the Newcastle disease virus (NDV) fusion glycoprotein, co-infiltrated with the NDV Matrix protein. In comparison, the native IB modified S co-infiltrated with IB virus membrane, envelope and nucleocapsid proteins, or substituted with the TM and CT of an H6-subtype influenza A virus hemagglutinin glycoprotein yielded lower VLP...
Source: PLoS One - July 20, 2023 Category: Biomedical Science Authors: Kamogelo M. Sepotokele Source Type: research
Spillover effects of the COVID-19 pandemic on attitudes to influenza and childhood vaccines
The current study sought to determine whether public perceptions of other vaccines and diseases than COVID-19 have been impacted by the COVID-19 pandemic. We longitudinally examined whether there had been a ch...
Source: BMC Public Health - April 25, 2023 Category: Consumer Health News Authors: Anna Soveri, Linda C. Karlsson, Jan Antfolk, Otto M äki, Linnea Karlsson, Hasse Karlsson, Saara Nolvi, Max Karukivi, Mikael Lindfelt and Stephan Lewandowsky Tags: Research Source Type: research
The ‘invented persona’ behind a key pandemic database
When Jeremy Kamil started to sequence samples of the rapidly spreading pandemic coronavirus in the spring of 2020, it was clear where he should deposit the genetic data: in
GISAID
, a long-running database for influenza genomes that had established itself as the go-to repository for SARS-CoV-2 as well.
Kamil, a virologist at Louisiana State University’s (LSU’s) Health Sciences Center Shreveport, says he quickly struck up a friendly relationship with a Steven Meyers, who used a gisaid.org email address. The two often exchanged emails and talked on the phone, sometimes for hours, about the pandemic and data sh...
Source: ScienceNOW - April 19, 2023 Category: Science Source Type: news
Bird shots: Is vaccinating poultry the best defense against a deadly bird flu?
Lakeside, California—
Hilliker’s Ranch Fresh Eggs in this San Diego suburb has 30,000 chickens in three “cage-free,” open-air barns, where birds crowd the floor like rush-hour riders on a big city subway. “A cage-free aviary is a very interesting science experiment,” says Frank Hilliker, who runs the farm his
grandfather started
in 1942. He worries mightily about infections spreading through the massed birds. On his iPhone, he pulls up a list of the vaccines his chickens get: against Newcastle disease, infectious laryngotracheitis, coryza, colibacillosis, salmonella, infectious bronchitis, and fowlpox....
Source: ScienceNOW - April 6, 2023 Category: Science Source Type: news
TWiV 991: The cancer mRNA shot
On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •1918 influenza virus not lethal in nonhuman primates (J Virol) •mRNA vaccines control HPV-associated tumors (Sci Trans Med) •Letters read on TWiV 991 •Timestamps by Jolene. Thanks! Weekly Picks Dickson ...
Source: This Week in Virology - MP3 Edition - March 12, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
AF03 adjuvant improves anti-hemagglutinin and anti-neuraminidase immune responses induced by licensed seasonal quadrivalent influenza vaccines in mice
Vaccine. 2023 Feb 18:S0264-410X(23)00169-X. doi: 10.1016/j.vaccine.2023.02.034. Online ahead of print.ABSTRACTSeasonal influenza remains a serious public health concern as the viral infection spreads easily from person to person and due to antigenic drift of neutralizing epitopes. Vaccination is the best method for disease prevention, however current seasonal influenza vaccines stimulate antibodies which are often effective against only antigenically similar strains. To boost the immune responses and increase vaccine effectiveness, adjuvants have been used for the past 20 years. The current study explores the use of oil-in...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Irina V Ustyugova Svetlana Pougatcheva Timothy Farrell Tod Strugnell Vardhini Ganesh Konstantin B Zeldovich Sudha Chivukula Ana P Goncalvez Mario Barro Source Type: research
IJERPH, Vol. 20, Pages 3376: Spillover of Vaccine Hesitancy into Adult COVID-19 and Influenza: The Role of Race, Religion, and Political Affiliation in the United States
Conclusions: Patterns of vaccine hesitancy and the non-receipt of the COVID-19 vaccination did not vary, indicating a substantial overlap and potential spillover in vaccine hesitancy over the course of the pandemic. Because changing people&rsquo;s opinions regarding vaccinations is generally a challenge, different interventions specific to demographic subgroups may be necessary.
Source: International Journal of Environmental Research and Public Health - February 15, 2023 Category: Environmental Health Authors: Victoria Zhang Peiyao Zhu Abram L. Wagner Tags: Article Source Type: research
Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed.
The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine
This study details the benefit of adjuvants that target multiple innate immune receptors to shape the host vaccine response.PMID:36426358 | PMC:PMC9679288 | DOI:10.3389/fimmu.2022.974016
Source: Cancer Control - November 25, 2022 Category: Cancer & Oncology Authors: Sonia Jangra Gabriel Laghlali Angela Choi Raveen Rathnasinghe Yong Chen Soner Yildiz Lynda Coughlan Adolfo Garc ía-Sastre Bruno G De Geest Michael Schotsaert Source Type: research
Live recombinant Newcastle disease virus vectored vaccine expressing the haemagglutinin of H9N2 avian influenza virus suppresses viral replication in chickens
In this study, rK148/Y280-HA, a novel recombinant Newcastle disease virus (NDV) vectored vaccine against Y280 lineage H9N2 LPAI was developed and evaluated using two mass-applicable administration methods, spray vaccination and drinking water vaccination. Regardless of low serum antibody haemagglutination inhibition titres against NDV and Y280 lineage H9N2 LPAI after applying the rK148/Y280-HA vaccine, vaccination with both administration methods protected chickens against virulent NDV and Y280-lineage H9N2 LPAIV after the challenge. Taken together, these results indicate that the rK148/Y280 vaccine can be administered usi...
Source: Avian Pathology - November 15, 2022 Category: Pathology Authors: Jiho Lee Andrew Y Cho Deok-Hwan Kim Joong-Bok Lee Seung-Yong Park In-Soo Choi Sang-Won Lee Chang-Seon Song Source Type: research
