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Post-Procedure Analgesic Management
This article will go in depth to explain the analgesic tools practitioners can implement for an effective low-risk protocol, including a combination of NSAIDS and acetaminophen approach, using long-acting local anesthetics such as Exparel, pregabalin, gabapentin, ketamine, dexmedetomidine, and corticosteroids, and enhanced recovery after surgery protocols.
Source: Dental Clinics of North America - September 15, 2023 Category: Dentistry Authors: Amanda Andre, Michael Benichou, Harry Dym Source Type: research
Pregabalin versus Gabapentin Efficacy in the Management of Neuropathic Pain Associated with Failed Back Surgery Syndrome
CONCLUSION: Both Pregabalin and Gabapentin effectively and safely relieve neuropathic pain associated with FBSS; Pregabalin was significantly more effective irrespective of the patients' gender.PMID:37709550 | DOI:10.3340/jkns.2022.0225
Source: Journal of Korean Neurosurgical Society - September 14, 2023 Category: Neurosurgery Authors: Laith Thamer Al-Ameri Mohammed Emad Shukri Ekhlas Khalid Hameed Ahmed Abed Marzook Source Type: research
Perioperative Anxiolysis and Analgesic Effect after Premedication with Melatonin and Pregabalin in Total Hip Arthroplasty under Spinal Anaesthesia: A Prospective Comparative Trial
CONCLUSIONS: Pregabalin was found better for perioperative anxiolysis, post-operative analgesia and for prolongation of duration of spinal anaesthesia when compared to melatonin.PMID:37694243 | PMC:PMC10492595 | DOI:10.4103/abr.abr_323_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Akash Mishra Vinod Kumar Srivastava Ravi Prakash Neel Kamal Mishra Jyotsna Agarwal Shruti Kabi Source Type: research
DDD-028: A Potent, Neuroprotective, Non-Opioid Compound for the Treatment of Diabetic Neuropathy
Bioorg Med Chem Lett. 2023 Sep 8:129472. doi: 10.1016/j.bmcl.2023.129472. Online ahead of print.ABSTRACTDiabetic neuropathy (DN) is a painful, chronic ailment that affects a large segment of diabetic population worldwide. Current medications such as pregabalin or duloxetine treat only the pain symptom associated with DN, but not the underlying nerve damage. DDD-028 (1) is a small molecule that displays potent pain-relieving activity in streptozotocin (STZ)-induced rodent model of DN. Combined with other studies indicating that DDD-028 suppresses astrogliosis and nerve damage induced by the anti-cancer drug, paclitaxel, the...
Source: Bioorganic and Medicinal Chemistry Letters - September 10, 2023 Category: Chemistry Authors: Laura Micheli Jagan Rajamoni Lorenzo Di Cesare Mannelli Parthasarathi Rajagopalan Carla Ghelardini Raghavan Rajagopalan Source Type: research
Pharmacological and Nonpharmacological Treatments for Painful Diabetic Peripheral Neuropathy
Diabetes Metab J. 2023 Sep 6. doi: 10.4093/dmj.2023.0018. Online ahead of print.ABSTRACTDiabetic peripheral neuropathy (DPN) is one of the most prevalent chronic complications of diabetes. The lifetime prevalence of DPN is thought to be >50%, and 15%-25% of patients with diabetes experience neuropathic pain, referred to as "painful DPN." Appropriate treatment of painful DPN is important because this pain contributes to a poor quality of life by causing sleep disturbance, anxiety, and depression. The basic principle for the management of painful DPN is to control hyperglycemia and other modifiable risk factors, but these...
Source: Diabetes and Metabolism Journal - September 6, 2023 Category: Endocrinology Authors: Han Na Jang Tae Jung Oh Source Type: research
