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Drug: Fentanyl
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Total 6124 results found since Jan 2013.
Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial
Conditions: Acute Pain Due to Trauma; Analgesia Interventions: Drug: Fentanyl Citrate; Drug: Esketamine Sponsors: Midas de Grunt; Stichting Ziektekosten Verzekering Krijgsmacht; Ambulance Amsterdam Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
A Survey of the Status of Methadone Switching in Japan Using a Hospital-Based Administrative Claims Database
In conclusion, more than 30% of the patients underwent high-dose methadone switching and required long completion periods, suggesting that methadone switching remains challenging in Japan. This article is protected by copyright. All rights reserved.PMID:37737471 | DOI:10.1002/jcph.2351
Source: The Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Authors: Shungo Imai Natsumi Aoki Keisuke Ikegami Hayato Kizaki Satoko Hori Source Type: research
Higher Buprenorphine Dose May Improve Treatment Retention for Opioid Use Disorder
Patients who received a higher daily dose of buprenorphine (24 mg) were significantly more likely to remain in treatment over six months compared with those who received a lower dose (16 mg), according to astudy published this week inJAMA Network Open.“The U.S. Food and Drug Administration recommends a target dose of 16 mg for buprenorphine maintenance treatment, with an upper limit of 24 mg,” wrote Laura Chambers, Ph.D., M.P.H., of Brown University and colleagues. The authors noted that this recommendation was established prior to the emerge nce of fentanyl in the illicit drug supply. “Some physicians have suggested...
Source: Psychiatr News - September 21, 2023 Category: Psychiatry Tags: buprenorphine discontinuation fentanyl JAMA Network Open Nora Volkow opioid use disorder Rhode Island treatment retention Source Type: research
Fentanyl-induced reward seeking is sex and dose dependent and is prevented by D-cysteine ethylester
Discussion: These findings suggest that D-CYSee is an effective co-treatment with prescribed opioids to reduce the development of OUD.
Source: Frontiers in Pharmacology - September 19, 2023 Category: Drugs & Pharmacology Source Type: research
Multimodal Analgesia in Pediatric Cancer Pain Management: A Retrospective Single-Center Study
Conclusions The pain level that pediatric cancer patients endure critically influences their and their family's quality of life. The fact that opioid-related adverse effects associated with pediatric pain management occur far less frequently than previously thought may help prevent opiophobia. Effective and safe analgesia can be provided with multimodal analgesia to manage pediatric cancer pain.PMID:37720121 | PMC:PMC10501176 | DOI:10.7759/cureus.45223
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Mesut Bak ır Şebnem Rumeli Argun Pire Source Type: research
Application of analgesics in emergency services in Germany: a survey of the medical directors
CONCLUSION: Effective analgesics are available for EMS staff in Germany, the approach to improvement lies in the area of application. For this purpose, the adaptations of the legal framework as well as the creation of a guideline for prehospital analgesia are useful.PMID:37710177 | DOI:10.1186/s12873-023-00878-8
Source: Pain Physician - September 14, 2023 Category: Anesthesiology Authors: Signe Vilcane Olga Scharonow Christian Weilbach Maximilian Scharonow Source Type: research
Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia
In this study, we investigated the development of dual-targeted ligands that bind to both μ-opioid receptor (MOR) and carbonic anhydrase (CA) enzymes, using fentanyl structure as a template. We synthesized and evaluated 21 novel compounds with dual-targeted affinity identifying the lead candidate compound 8, showing selective affinity for MOR and potent inhibition of several cytosolic CA isoforms. By means of repeated treatment of 3 daily administrations for 17 days, fentanyl (0.1 mg/kg, subcutaneously) led to tolerance development, pain threshold alterations and withdrawal symptoms in CD-1 mice, as well as astrocyte and ...
Source: European Journal of Medicinal Chemistry - September 7, 2023 Category: Chemistry Authors: Andrea Angeli Laura Micheli Rita Turnaturi Lorella Pasquinucci Carmela Parenti Vincenzo Alterio Anna Di Fiore Giuseppina De Simone Simona Maria Monti Fabrizio Carta Lorenzo Di Cesare Mannelli Carla Ghelardini Claudiu T Supuran Source Type: research
Ardmore Nurse Pleads Guilty to Tampering with Pain Medication
FDA OCI, Rebecca Elaine Holloway, Oklahoma City, OK, guilty plea, information, tampering, fentanyl, hydromorphone, Intensive Care Unit, ICU, Mercy Hospital, Ardmore, replace, tap water, risk, death, injury,
Source: Office of Criminal Investigations (OCI) Press Releases - September 5, 2023 Category: Medical Law Authors: DOJ Source Type: news
Comparison of three regimens with inhalational methoxyflurane versus intranasal fentanyl versus intravenous morphine in pre-hospital acute pain management: study protocol for a randomized controlled trial (PreMeFen)
DiscussionWe chose a study design with comparison of analgesic regimens rather than fixed doses because of the substantial differences in drug characteristics and for the results to be relevant to inform policymakers in the pre-hospital setting. We recognize that easier administration of analgesics will lead to better pain management for many patients if the regimens are as good as the existing, and hence, we chose a non-inferiority design. The primary endpoint, the change in pain (NRS) after 10 min, is set to address the immediate need of pain reduction for patients with acute prehospital pain. On a later stage, more an...
Source: Trials - September 5, 2023 Category: Research Source Type: clinical trials
Effects of an intravenous lidocaine bolus before tracheal extubation on recovery after breast surgery - Lidocaine at the End (LATE) study: a randomized controlled clinical trial
CONCLUSION: In women who underwent breast surgery, IV lidocaine bolus administered just before extubation attenuated bucking, cough and sore throat, and PONV for 24 hours after general anesthesia, without prolonging the emergence.PMID:37654034
Source: Croatian Medical Journal - September 1, 2023 Category: General Medicine Authors: Boris Mraovic Tatjana Šimurina Source Type: research
