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Drug: Dexamethasone
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Total 4131 results found since Jan 2013.
Dexamethasone inhibits IL-8 via glycolysis and mitochondria-related pathway to regulate inflammatory pain
Dexamethasone (Dexa) has been recently found to exert an analgesic effect, whose action is closely related to IL-8. However, whether dexamethasone induces antinociception via glycolysis and mitochondria-relate...
Source: BMC Anesthesiology - September 18, 2023 Category: Anesthesiology Authors: Ren He, Xiaohan Li, Silun Zhang, Yuqiang Liu, Qingsheng Xue, Yan Luo, Buwei Yu, Xiongjuan Li and Zhiheng Liu Tags: Research Source Type: research
Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications
AbstractSpinal cord injury (SCI) encompasses a plethora of complex mechanisms like the involvement of major cell death pathways, neurodegeneration of spinal cord neurons, overexpression of glutaminergic transmission and inflammation cascade, along with different co-morbidities like neuropathic pain, urinary and sexual dysfunction, respiratory and cardiac failures, making it one of the leading causes of morbidity and mortality globally. Corticosteroids such as methylprednisolone and dexamethasone, and non-steroidal anti-inflammatory drugs such as naproxen, aspirin and ibuprofen are the first-line treatment options for SCI, ...
Source: Pharmaceutical Medicine - September 12, 2023 Category: Drugs & Pharmacology Source Type: research
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration
CONCLUSIONS: Aprepitant X formulation is a promising candidate for the treatment of pain associated with inflammation of the ocular surface.PMID:37690516 | DOI:10.1016/j.jtos.2023.09.004
Source: The Ocular Surface - September 10, 2023 Category: Opthalmology Authors: Filippo Bonelli Ibrahim Demirsoy Romina Mayra Lasagni Vitar Philippe Fonteyne Giulio Ferrari Source Type: research
Perioperative anaesthesia by local infiltration following median sternotomy - a study protocol
CONCLUSION: This trial will define whether the use of long-acting infiltration anaesthesia during heart surgery may reduce acute and prolonged post-operative opioid consumption. Reduction of opioid-related adverse effects may improve recovery.FUNDING: The trial is supported by public grants (Dansk Selskab for Anæstesiologi og Intensiv Medicin: 40,000 DKK; Regionernes Medicin og Behandlingspulje 2022: 686,000 DKK). The work of I. S. Modrau is supported by an unrestricted grant from the Health Research Foundation of the Central Denmark Region.TRIAL REGISTRATION: EudraCT 2021-005886-41.PMID:37622639
Source: Danish Medical Journal - August 25, 2023 Category: General Medicine Authors: Jonas Juel Rasmussen Jannie Bisgaard Peter Juhl-Olsen Jesper Langhoff H ønge Ivy Susanne Modrau Source Type: research
