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The Anesthesiology Physician-Scientist Pipeline: Current Status and Recommendations for Future Growth-An Initiative of the Anesthesia Research Council
Anesth Analg. 2023 Oct 1;137(4):728-742. doi: 10.1213/ANE.0000000000006520. Epub 2023 Sep 5.ABSTRACTThe limited number and diversity of resident physicians pursuing careers as physician-scientists in medicine has been a concern for many decades. The Anesthesia Research Council aimed to address the status of the anesthesiology physician-scientist pipeline, benchmarked against other medical specialties, and to develop strategic recommendations to sustain and expand the number and diversity of anesthesiology physician-scientists. The working group analyzed data from the Association of American Medical Colleges and the Nationa...
Source: Pain Physician - September 15, 2023 Category: Anesthesiology Authors: Charles W Emala Vivianne L Tawfik Meghan B Lane-Fall Paloma Toledo Cynthia A Wong Monica S Vavilala Lee A Fleisher Margaret Wood Source Type: research
Notice announcing HEAL Initiative Technical Assistance Webinar: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trials and U24 Resource and Data Center)
Notice NOT-HD-23-025 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 11, 2023 Category: Research Source Type: funding
Gouty arthritis with acromioclavicular joint pain as the first predictor
Asian J Surg. 2023 Sep 7:S1015-9584(23)01412-4. doi: 10.1016/j.asjsur.2023.09.010. Online ahead of print.NO ABSTRACTPMID:37689517 | DOI:10.1016/j.asjsur.2023.09.010
Source: Asian Journal of Surgery - September 9, 2023 Category: Surgery Authors: Yiquan Sun Le Wang Courtney Grant Jr Kang Tian Source Type: research
Treatment Effect Estimates from Pilot Trials Are Unreliable
The CONSORT guideline defines a pilot trial as a small-scale version of a desired future efficacy trial that is intended to answer the key questions of whether and how a larger study should be done. For example, a pilot trial might evaluate willingness of participants to undergo randomization or test different instruments for measuring an outcome. In addition to assessing feasibility of a future study, many investigators use pilot trials to obtain preliminary estimates of efficacy that might be used to gauge the promise of a new intervention, or to use in grant proposals to justify research funding.
Source: Journal of Pain and Symptom Management - September 2, 2023 Category: Palliative Care Authors: Jesse D. Troy, Megan L. Neely, Gina-Maria Pomann, Steven C. Grambow, Gregory P. Samsa Tags: Methodological Reviews Source Type: research
Researchers applaud health officials ’ push to ease cannabis restrictions
Federal health officials are urging the U.S. Drug Enforcement Administration (DEA) to loosen its restrictions on cannabis—a move that could make it easier for researchers to study the drug’s potential medical benefits and harms. Following a review
initiated by the White House in 2022
, the U.S. Department of Human Health and Services (HHS) this week recommended that DEA reclassify cannabis from its Schedule I category, which includes drugs considered to have a high potential for abuse and no accepted therapeutic value, such as heroin and LSD, to the lower risk Schedule III. If implemented, the policy cha...
Source: ScienceNOW - September 1, 2023 Category: Science Source Type: news
Researchers applaud health officials ’ push to ease marijuana restrictions
Federal health officials are urging the U.S. Drug Enforcement Administration (DEA) to loosen its restrictions on marijuana—a move that could make it easier for researchers to study the drug’s potential medical benefits and harms. Following a review
initiated by the White House in 2022
, the U.S. Department of Human Health and Services (HHS) this week recommended that DEA reclassify marijuana from its Schedule I category, which includes drugs considered to have a high potential for abuse and no accepted therapeutic value, such as heroin and LSD, to the lower risk Schedule III. If implemented, the policy c...
Source: ScienceNOW - September 1, 2023 Category: Science Source Type: news
HEAL INITIATIVE: Development and validation of remote or patient wearable device derived objective biosignatures or functional assessments to monitor pain for use as endpoints in clinical trials (UG3/UH3 - Clinical Trial Optional)
Funding Opportunity RFA-NS-24-023 from the NIH Guide for Grants and Contracts. To enable the development and validation of real-world remote digital endpoints from wearable devices for monitoring pain experience and progression, response to interventions, and impact on quality of life. In the context of this RFA, endpoints will include biosignatures derived from functional and physiological assessments detected from wearable devices. These biosignatures can be used to monitor the effects of therapeutics developed for the treatment of pain.
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 1, 2023 Category: Research Source Type: funding
Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort
EClinicalMedicine. 2023 Jul 21;62:102107. doi: 10.1016/j.eclinm.2023.102107. eCollection 2023 Aug.ABSTRACTBACKGROUND: Lack of specific definitions of clinical characteristics, disease severity, and risk and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and discovery of new preventive and therapeutics drugs.METHODS: This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- and in-patients followed at 3-, 6-, and 12-month from diagnosis, with assessment of clinical and biochemical features, antibody (Ab) response, Variant o...
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Elisa Gentilotti Anna G órska Adriana Tami Roy Gusinow Massimo Mirandola Jes ús Rodríguez Baño Zaira R Palacios Baena Elisa Rossi Jan Hasenauer Iris Lopes-Rafegas Elda Righi Natascia Caroccia Salvatore Cataudella Zeno Pasquini Thomas Osmo Lidia Del Pi Source Type: research
Sunday Sermonette: Despair
Job responds with what amounts to despair. He wants to die, and he wants his despair to be respected. This soliloquy, and especially the second half of it in the next chapter, reminds me of Hamlet ' s " Oh that this too, too solid flesh would melt " soliloquy, the somewhat lesser known one. But as a literary critic, I would say that Shakespeare does it much more efficiently. This runs through an excessive amount of imagery to make a pretty simple statement.6 Then Job replied:2 “If only my anguish could be weighed and all my misery be placed on the scales!3 It would surely outweigh th...
Source: Stayin' Alive - August 27, 2023 Category: American Health Source Type: blogs
Perioperative anaesthesia by local infiltration following median sternotomy - a study protocol
CONCLUSION: This trial will define whether the use of long-acting infiltration anaesthesia during heart surgery may reduce acute and prolonged post-operative opioid consumption. Reduction of opioid-related adverse effects may improve recovery.FUNDING: The trial is supported by public grants (Dansk Selskab for Anæstesiologi og Intensiv Medicin: 40,000 DKK; Regionernes Medicin og Behandlingspulje 2022: 686,000 DKK). The work of I. S. Modrau is supported by an unrestricted grant from the Health Research Foundation of the Central Denmark Region.TRIAL REGISTRATION: EudraCT 2021-005886-41.PMID:37622639
Source: Danish Medical Journal - August 25, 2023 Category: General Medicine Authors: Jonas Juel Rasmussen Jannie Bisgaard Peter Juhl-Olsen Jesper Langhoff H ønge Ivy Susanne Modrau Source Type: research
